Abstract.Plants consumed by non-human primates represent potential drug sources for human disease management. In this study, we isolated kaempferol-3-O-rhamnoside as an active compound from the leaves of Schima wallichii Korth., a plant commonly consumed by non-human primates. Its anti-cancer activities, including its ability to induce apoptotic mechanisms, were investigated in MCF-7 breast cancer cells. Results showed that in MCF-7 cells, kaempferol-3-O-rhamnoside inhibits cell proliferation in a dose-dependent manner and promotes apoptosis via the activation of the caspase signaling cascade, which includes caspase-9, caspase-3 and PARP. Our results provide a basis for further exploration of kaempferol-3-O-rhamnoside as an active compound for potential anti-cancer therapeutics.

− Seven flavonoid compounds, kaempferol (1), quercetin (2), quercetin (6) and quercetin-3-O-rutinoside (7), were isolated from the methanolic extract of leaves of Kalanchoe prolifera. Compounds 1-7 were isolated for first time from this plant. These compounds were evaluated their cytotoxic activity against P-388 murine leukimia cells in vitro. Among those compounds kaempferol (1) and quercetin (2) showed strongest cytotoxic activity with IC 50 values of 4.45 ± 0.05 and 6.28 ± 0.02 μg/mL, respectively.

Functional cotton fabric incorporated with antibacterial microcapsules of lime (C. aurantifolia) essential oil (LO) was prepared.

Introduction: The essential oils of orange peels had a considerable potential to be used as an antimicrobial agent. The aim of this present study is to analized chemical composition of Citrus spp. And the oral antimicrobial effect of Citrus spp. peels essential oils against Streptococcus mutans. Methods: Five orange peels species were used in this study consist of Lime (Citrus aurantifolia), Tangerine (Citrus nobilis), Sweet Orange (Citrus sinensis), Lemon (Citrus limon), and Kaffir Lime (Citrus hystrix). The isolated essential oils were analyzed using gas chromatography-mass spectroscopy (GC-MS). The Streptococcus mutans ATCC 25175 was employed against the antimicrobial effect of samples. Results: The extraction yields of hydrodistilled-essential oils from Tangerine, Kaffir Lime, Sweet Orange, Lemon, and Lime provided the extraction yields of 4.20, 2.26, 1.97, 1.74 and 0.83% yields, respectively. Major component essential oils of Citrus spp. was D-Limonene. The highest antimicrobial activity against S. mutans was Lime peel essential oil, followed by Lemon, Kaffir Lime, and Sweet Orange or Tangerine. All samples showed antimicrobial activity against S. mutans with the variation of antimicrobial action depending on the constituent of D-Limonene, β-Pinene, and α-terpineol. Conclusion: Major component chemical composition of essential oils of Citrus spp. was D-Limonene and antimicrobial activity by Lime peel essential oil due to its proportional amount of D-limonene and β-pinene and the highest antimicrobial activity.

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Pada penelitian ini telah dilakukan destilasi minyak kulit jeruk nipis (Citrus aurantifolia) dengan menggunakan alat hidrodestilasi Stahl dan pembuatan mikrokapsulnya menggunakan polimer etil selulosa. Metode pembuatan mikrokapsul yang digunakan adalah difusi solven-emulsi/coacervation, dengan memvariasikan rasio minyak terhadap air (o/w) dan rasio core/shell sementara penggunaan jumlah emulsifier tween 80 dan PVA masingmasing sebesar 2% dan 0,8%. Karakterisasi minyak jeruk nipis dilakukan menggunakan GC-MSD dan spektrofotometer, sedangkan morfologi mikrokapsul menggunakan SEM. Hasil percobaan menunjukkan bahwa minyak kulit jeruk nipis mengandung komponen utama 1-limonen dengan serapan maksimum teramati pada λ =296 nm. Kondisi percobaan optimum pembuatan mikrokapsul tercapai pada rasio o/w = 1:20 dan rasio core/shell= 2:1,5. Ukuran mikrokapsul minyak jeruk nipis sangat random berkisar 17,9 hingga 120,6 µm.

Flavonoids compounds such as kaempferol (1), kaempferol-3-O--D-glucopyranoside or astragalin (2) and kaempferol-3-O--L-rhamnoside or afzelin (3) have been isolated from the fresh leaves of Kalanchoe tomentosa (Crassulaceae). The chemical structure of isolated compounds 1-3 were identified by spectroscopic evidences and comparison with those compound previously reported. Compounds 1-3 showed cytotoxic activity against P-388 murine leukimia cells with IC 50 values of 51.8, 100 and 3.32 μg/mL, respectively.

Uncaria gambir Roxb. is a plant from Southeast Asia and is widely used as an alternative medicine with various applications. This plant has been widely used in traditional medicine. This paper aims to provide information on U. gambir, a summary of data on phytochemicals and on medical and nonmedical activities. Phytochemical studies reveal biologically active constituents such as flavonoids, phenolics, and alkaloids. Various studies have shown that extracts and compounds obtained from U. gambir have medical uses for their antioxidant, antibacterial, anti-helminthic, anticancer, antifungal, anti-inflammatory, anti-hyperglycemic, anti-hyperuricemic, anti-lipid peroxidation, antihyperlipidemic and other properties. In addition, this extract has other uses, such as adsorbent for dyes and metal ions, as well as corrosion inhibition. Thus, U. gambir, which is commonly used in traditional medicine, is a potential plant for many therapeutic applications and prospects for drug development as well as other applications such as adsorbent and corrosion inhibition.