− Seven flavonoid compounds, kaempferol (1), quercetin (2), quercetin (6) and quercetin-3-O-rutinoside (7), were isolated from the methanolic extract of leaves of Kalanchoe prolifera. Compounds 1-7 were isolated for first time from this plant. These compounds were evaluated their cytotoxic activity against P-388 murine leukimia cells in vitro. Among those compounds kaempferol (1) and quercetin (2) showed strongest cytotoxic activity with IC 50 values of 4.45 ± 0.05 and 6.28 ± 0.02 μg/mL, respectively.
A new limonoid, pentandricine (1), along with three known limonoids, ceramicine B (2), 6-de(acetyloxy)-23-oxochisocheton (3), 6-de(acetyloxy)-23-oxo-7-O-deacetylchisocheton (4), have been isolated from the stembark of Chisocheton pentandrus. The chemical structures of the new compound were elucidated on the basis of spectroscopic evidence. All of the compounds were tested for their cytotoxic effects against MCF-7 breast cancer cells. Compounds 1-4 showed weak and no cytotoxicity against MCF-7 breast cancer cells with IC values of 369.84, 150.86, 208.93 and 120.09 μM, respectively.
Four new compounds, acacetin 8-C-[-D-apiofuranosyl-(1 → 2)--D-glucopyranoside] (), 7-methoxyacacetin 8-C-[-D-apiofuranosyl-(1 → 3)--D-glucopyranoside] (), 7-methoxyacacetin 8-C-[-D-glucopyranosyl-(1 → 2)--D-glucopyranoside] (), and 4‴-O-acetylacacetin 8-C-[-L-rhamnopyranosyl-(1 → 2)--D-glucopyranoside] (), along with ten known compounds (-), were isolated from leaves. The effects of these compounds on lipopolysaccharide-induced expression of the proinflammatory cytokines IL-12 p40, IL-6, and TNF- in bone marrow-derived dendritic cells were evaluated. Compounds , and- inhibited the production of both IL-12 p40 and IL-6, with IC values ranging from 0.35 ± 0.01 to 1.40 ± 0.04 µM and 1.22 ± 0.02 to 3.79 ± 0.10 µM, respectively. Compounds and only showed strong inhibition effects on the production of IL-12 p40, with IC values of 2.76 ± 0.08 and 0.39 ± 0.05 µM, respectively. However, all compounds showed weak activity or no activity on TNF- production at the tested concentrations.
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