The bark of Mimosa tenuiflora (Willd.) Poiret (Leguminosae family), popularly known as “jurema preta” in Brazil, is used by the population of Contendas of Sincorá (Bahia State, Brazil) for the treatment of coughs and wound healing. Thus, the aim of this study was to evaluate the antinociceptive and anti-inflammatory activities of the bark ethanol extract (EEMT) and solvent soluble fractions (hexane—H, DCM—D, EtOAc—E and BuOH—B) of the extract in vivo. Additionally, we synthesized 5,7-dihidroxy-4’-methoxyflavanone (isosakuranetin) and isolated the compound sakuranetin, and both compounds were also tested. The anti-inflammatory and antinociceptive assays performed were: writhing test; nociception induced by intraplantar formalin injection; leukocyte recruitment to the peritoneal cavity; evaluation of vascular permeability (Evans blue test); and evaluation of mechanical hypernociception (von Frey test). Production of TNF-α, IL-10, myeloperoxidase and the expression of ICAM-1 were also evaluated. Statistical analysis was performed by one-way ANOVA followed by the Bonferroni post-test (n = 8), with P < 0.05. The EEMT showed antinociceptive activities in writhing test (100–200 mg/kg), in the second phase of the formalin test (50–200 mg/kg), and in mechanical hypernociception (100 mg/kg). EEMT showed an anti-inflammatory effect by reducing neutrophil migration to the peritoneal cavity and in the plantar tissue detected by the reduction of myeloperoxidase activity (100 mg/kg), reduction of IL-10 levels and expression of ICAM-1 in the peritoneal exudate and the mesentery (100 mg/kg), respectively. The four soluble EEMT fractions showed good results in tests for antinociceptive (H, D, E, B) and anti-inflammation (H, D, E). Only sakuranetin showed reduction of the writhing and neutrophil migration (200 mg/kg). Thus, the EEMT and soluble fractions of M. tenuiflora bark demonstrated great antinociceptive and anti-inflammatory activities, as also sakuranetin. More studies should be conducted to elucidate the mechanism of action of this compound. To the best of our knowledge, this is the first report on the antinociceptive activity of the M. tenuiflora fractions and the bioactive isolated compound sakuranetin in vivo.
BACKGROUND Sepsis is a set of serious organic manifestations caused by an infection, whose progression culminates in exacerbated inflammation and oxidative stress, poor prognosis, and high hospital costs. Antioxidants used against sepsis have been evaluated, including essential oils such as β‐caryophyllene (BCP), and polyunsaturated fatty acids, such as docosahexaenoic acid (DHA). The aim of this study was to evaluate the anti‐inflammatory activity of the association of these two compounds. RESULTS Treatment with BCP‐DHA, at a dose of 200 μL/animal, significantly inhibited the migration of neutrophils in a Cg‐induced peritonitis model. After Staphylococcus aureus infection, in the groups treated with BCP‐DHA there was a significant decrease in the total and differential count of leukocytes, increased expression of cytokines TNF‐α and IFN‐γ in treated groups, an increase of IL‐4 and IL‐5 in B/D and B/D + SA groups, and an augmentation of IL‐6 and IL‐12 groups in B/D + SA groups. Histological and bacterial analysis revealed lower neutrophil migration and lower bacterial load in the infected and treated groups. CONCLUSION In general, the BCP‐DHA association presented anti‐inflammatory activity against two different models of acute inflammation and infection, showing promising potential as a therapeutic adjuvant in sepsis. © 2019 Society of Chemical Industry
Resumo: A vacinação de adolescentes contra o Papiloma Vírus Humano -HPV é uma estratégia do Ministério da Saúde junto como o Programa Nacional de Imunização, que tem como público alvo meninas entre 9 a 14 anos e meninos de 12 a 13 anos, possuindo como porta de entrada as escolas e/ou Unidade Básica de Saúde. A vacinação tem por objetivo prevenir a incidência de novos casos de câncer do Colo do Útero e câncer de Pênis. Diante do exposto, o presente estudo tem como objetivo analisar a cobertura vacinal do HPV em adolescentes do sexo feminino e masculino no município de Ibiassucê, localizado no sudoeste da Bahia. Trata-se de uma pesquisa exploratória, revisão bibliográfica e quantitativa do tipo descritiva. Os dados foram coletados do Departamento de Informática do Sistema Único de Saúde (DATASUS). Palavras-chave:Vacina; Doenças Sexualmente Transmissíveis; Escola; Papiloma vírus Humano; HPV Vaccinal Coverage for Adolescents: Challenges and PossibilitiesAbstract: The vaccination of adolescents against human papillomavirus (HPV) is a strategy of the Ministry of Health along with the National Program of Immunization, which has as public target girls between 9 to 14 years and boys from 12 to 13 years old, possessing as a gateway schools and / or Basic Health Unit. Vaccination aims to prevent the incidence of new cases of cervical cancer and penile cancer. In view of the above, the present study aims to analyze the HPV vaccination coverage in female and male adolescents in the municipality of Ibiassucê, located in the southwest of Bahia. This is an exploratory research, bibliographical and quantitative review of the descriptive type. Data were collected from the Department of Informatics of the Unified Health System (DATASUS).
The treatment of dams at the end of pregnancy and lactation with L. plantarum Lp62 increased nutritional content of milk, probably contributing to the higher weight of the pups. The higher levels of TGF-β1 in the milk, could promote immune benefits to the pups. Further studies in this field are needed to prove the potential use of L. plantarum Lp62 as a probiotic.
Resumo: Atualmente existe uma grande preocupação em preservar a saúde e o bem-estar global da população idosa. Com isso, essa pesquisa teve o objetivo avaliar a qualidade de vida das pessoas idosas que apresentam dores crônicas. O estudo Trata-se de uma pesquisa de campo, exploratória, com abordagem quantitativa, realizada nas unidades de saúde do município de Jussiape-Ba, Brasil. Os instrumentos utilizados foram: questionário de qualidade de vida WHOQOL-Bref. Verificou-se que existem quanto à prevalência da dor crônica por local, tabela 1 prevaleceu a coluna lombar com 40%, enquanto a Intensidade da dor foi avaliada na tabela 2, cujo dor insuportável 38,33% dos entrevistados, segundo a tabela 3. a energia que tem é muito suficiente para 63,33%, aparência física, 56,67% muito satisfeito, 73,33% está com suficiência média em dinheiro, 38,33% avalia media disponibilidade das informações e a oportunidades de atividade de lazer 60% diz ser pouca. Foi discutido também sobe o analgésico mais usado para aliviar a dor musculoesquelética. Portanto, mesmo com as obscuridades que rondam a complexidade de se avaliar a dor no idoso, cabe à enfermagem assumir papel preponderante relacionado a esta questão.Palavras-chave: qualidade de vida, dor crônica, relação social. The Elderly and Chronic Pain: How to Live With ThemAbstract: There is now a great concern to preserve the overall health and well-being of the elderly population. Therefore, this research had the objective to evaluate the quality of life of the elderly who present chronic pain. The study this is an exploratory field research, with a quantitative approach, carried out in the health units of the municipality of Jussiape-Ba, Brazil. The instruments used were WHOQOLBref quality of life questionnaire. It was verified that there are as to the prevalence of chronic pain per local, table 1 prevailed the lumbar spine with 40%, while Pain intensity was assessed in table 2, whose unbearable pain 38.33% of respondents, according to table 3. The energy it has is sufficient for 63.33%, physical appearance, 56.67% very satisfied, 73.33% is with average sufficiency in money, 38.33% assess media availability of information and opportunities for leisure activity 60% say they are few. Also discussed is the most commonly used analgesic to relieve musculoskeletal pain. Thus, even with the obscurity surrounding the complexity of assessing pain in the elderly, it is incumbent upon nursing to assume a preponderant role related to this issue.
Trichilia ramalhoi Rizz. is a species from Meliaceae family and its chemical composition and biological activities are still unknown. This work describes the chemical composition and biological activities of the organic extracts of this plant. Therefore, methanolic extract of stem barks and leaves were prepared and submitted to chromatographic procedures. Besides, T. ramalhoi extracts biological evaluation showed antioxidant, antinociceptive and, anti-inflammatory activities. Usual chromatographic procedures of the active extracts permitted to isolate methyl 5-O-caffeoylquinate, apocynin C, cinchonains Ia and Ib, besides β-sitosterol, stigmasterol and lupeol. The
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