Anticariogenic activities of Libidibia ferrea, gallic acid and ethyl gallate against Streptococcus mutans in biofilm model

Passos, Manuela Ribeiro; Almeida, Rafael Silva; Lima, Brenda Oliveira; Rodrigues, Jeisa Zielle de Souza; Neres, Nayara Silva de Macêdo; Pita, Louise Soares; Marinho, Patrick D'Orleans Farias; Santos, Iago Almeida; Silva, Jamile Pinheiro da; Oliveira, Milena Cardoso; Oliveira, Mariana Araújo; Pessoa, Stela Mares Brasileiro; Silva, Marlon Mário Leles; Silveira, Paulo Henrique Santana; Reis, Mariane Mares; Santos, Isabella Porto; Ricardo, Luccas de Oliveira Negrão; Andrade, Leonardo Oliveira Silva Bastos; Soares, Ananda Brito; Correia, Thiago Macêdo Lopes; Souza, Érika Pereira de; Pires, Polyane Novais; Cruz, Manoel Jerônimo Moreira; Marques, Lucas Miranda; Uetanabaro, Ana Paula Trovatti; Yatsuda, Regiane

doi:10.1016/j.jep.2021.114059

Cited by 19 publications

(22 citation statements)

References 42 publications

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“…Figure 7 shows the colony numbers for each of the bacteria that were tested with all biocomposite films. It is seen that FA and GA, whose antibacterial properties have been proven in previous studies, [49][50][51] also maintain this activity in the PCL film. When compared to the control sample, neat PCL and all biocomposite films were seen the preventing the adherence of bacteria to the film surfaces by 80% or more (Figure 7).…”

Section: Antibacterial Propertiessupporting

confidence: 57%

Antibacterial and antioxidant phenolic compounds loadedPCLbiocomposites for active food packaging application

Diken

Kızılduman

Doğan

et al. 2022

J of Applied Polymer Sci

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Active food packages must not only act as a protective food barrier but also exhibit radical scavenging activity, antibacterial and controlled release properties that can have a positive effect on food quality, safety and shelf life. In this study, poly(ε-caprolactone) (PCL)/ferulic acid (FA) and PCL/gallic acid (GA) biocomposites were prepared by melt blending method to use in active food packaging applications. The physicochemical properties of the prepared biocomposites were investigated by FTIR-ATR, SEM, and DMA. In addition, antioxidant and antibacterial activities, water contact angle, oscillation test and water vapor transmission rate of biocomposites were also investigated. FTIR-ATR and SEM results showed that both fillers were well dispersed in the PCL matrix. Dynamic mechanical analysis was performed to examine the mechanical behavior of the samples and to determine their T g temperatures. The biocomposites exhibited a higher storage modulus and loss modulus than pure PCL. Especially, the glass transition temperature of the PCL/FA sample containing 5 wt.% FA increased 17 C compared to the neat PCL. They exhibited high-scavenging activity against DPPH and ABTS radicals, and showed high-antibacterial activity against both E. coli and S. aureus bacteria.

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Section: Antibacterial Propertiessupporting

confidence: 57%

Antibacterial and antioxidant phenolic compounds loadedPCLbiocomposites for active food packaging application

Diken

Kızılduman

Doğan

et al. 2022

J of Applied Polymer Sci

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“…The authors also reported in vitro inhibition of S. mutans biofilms, demonstrating the antimicrobial activity of gallic acid [ 57 ]. Likewise, Passos et al (2021) reported the antimicrobial and anti-adherence activity of gallic acid, an isolated compound of the ethanolic extract of L. ferrea , which exhibited significant antimicrobial activity and inhibition of adhesion of S. mutans biofilms [ 58 ].…”

Section: Resultsmentioning

confidence: 99%

New Perspectives on the Sustainable Employment of Chestnut Shells as Active Ingredient against Oral Mucositis: A First Screening

Ferreira

Silva

Pinto

et al. 2022

IJMS

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Oral mucositis (OM), a common side effect of oncological treatment, is an oral mucosal disorder characterized by painful ulcerations and increased risk of infection. The use of natural antioxidants to suppress the redox imbalance responsible for the OM condition has emerged as an interesting approach to prevent/treat OM. This study aims to explore the chestnut (Castana sativa) shells as potential active ingredient against OM. Therefore, chestnut shells were extracted at different temperatures (110–180 °C) by Subcritical Water Extraction (SWE), aiming to recover antioxidants. The extracts were also evaluated against microorganisms present in the oral cavity as well as on human oral cell lines (TR146 and HSC3). The highest phenolic content was obtained with the extraction temperature of 110 °C, exhibiting the best antioxidant/antiradical activities and scavenging efficiencies against HOCl (IC50 = 4.47 μg/mL) and ROO• (0.73 μmol TE/mg DW). High concentrations of phenolic acids (e.g., gallic and protocatechuic acids) and flavanoids (catechin, epicatechin and rutin) characterized the phenolic profile. The antimicrobial activity against several oral microorganisms present in the oral cavity during OM, such as Streptococcus, Staphylococcus, Enterococcus, and Escherichia, was demonstrated. Finally, the effects on HSC3 and TR146 cell lines revealed that the extract prepared at 110 °C had the lowest IC50 (1325.03 and 468.15 µg/mL, respectively). This study highlights the potential effects of chestnut shells on OM.

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“…Many other studies have suggested that various plants produce anti-biofilm natural phenolic compounds that have a capability to control dental biofilm [21,22]. Gallic acid can prevent the growth of oral microbes and inhibit the dental biofilm formation by S. mutans [23,24]. However, for this study different bacteria, including Proteus spp., Escherichia coli, Pseudomonas spp., Salmonella spp., Streptococcus mutans, and Staphylococcus aureus and mixed species bacteria were used.…”

Section: Introductionmentioning

confidence: 87%

“…Phenolic compounds or polyphenols, such as chlorogenic, caffeic, and gallic acids are widely used as a universal group of plant extract, which are highly antimicrobial and have other biological effects [23]. Gallic acid is frequently found in various Quercus rubor (oak) bark, Camellia sinensis (tea) leaves and seeds of Vitis vinifera (grapes), while caffeic and chlorogenic acids are found in other plants such as Triticum, Oryza sativa and Camellia sinensis [17,25].…”

Section: Introductionmentioning

confidence: 99%

Combating Biofilm by Targeting Its Formation and Dispersal Using Gallic Acid against Single and Multispecies Bacteria Causing Dental Plaque

et al. 2021

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Exploring biological agents to control biofilm is a vital alternative in combating pathogenic bacteria that cause dental plaque. This study was focused on antimicrobial, biofilm formation and biofilm dispersal efficacy of Gallic acid (GA) against bacteria, including Proteus spp., Escherichia coli, Pseudomonas spp., Salmonella spp., Streptococcus mutans, and Staphylococcus aureus and multispecies bacteria. Biofilm was qualitatively and quantitatively assessed by crystal violet assay, florescence microscopy (bacterial biomass (µm2), surface coverage (%)) and extracellular polymeric substances (EPS). It was exhibited that GA (1–200 mg/L) can reduce bacterial growth. However, higher concentrations (100–200 mg/L) markedly reduced (86%) bacterial growth and biofilm formation (85.5%), while GA did not exhibit any substantial dispersal effects on pre-formed biofilm. Further, GA (20–200 mg/L) exhibited 93.43% biomass reduction and 88.6% (p < 0.05) EPS (polysaccharide) reduction. Microscopic images were processed with BioImageL software. It was revealed that biomass surface coverage was reduced to 2% at 200 mg/L of GA and that 13,612 (µm2) biomass was present for control, while it was reduced to 894 (µm2) at 200 mg/L of GA. Thus, this data suggest that GA have antimicrobial and biofilm control potential against single and multispecies bacteria causing dental plaque.

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Anticariogenic activities of Libidibia ferrea, gallic acid and ethyl gallate against Streptococcus mutans in biofilm model

Cited by 19 publications

References 42 publications

Antibacterial and antioxidant phenolic compounds loadedPCLbiocomposites for active food packaging application

Antibacterial and antioxidant phenolic compounds loadedPCLbiocomposites for active food packaging application

New Perspectives on the Sustainable Employment of Chestnut Shells as Active Ingredient against Oral Mucositis: A First Screening

Combating Biofilm by Targeting Its Formation and Dispersal Using Gallic Acid against Single and Multispecies Bacteria Causing Dental Plaque

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