Abstrak Infeksi Soil Transmitted Helminth (STH) adalah salah satu infeksi cacing paling umum Hal ini ditemukan dalam hubungan dengan kebersihan pribadi yang buruk, sanitasi yang buruk, dan di daerah-daerah yang menggunakan kotoran cacing ini sebagai pupuk. Salah satu pekerjaan yang sangat erat kaitannya dengan infeksi STH adalah pekerjaan yang berhubungan dengan tanah yaitu bertani. Infeksi A. lumbricoides mengaktifasi respon sel Th2 yang kemudian melepaskan sitokin IL-4, IL-9 dan IL-13 untuk merespon antigen parasit yang kemudian bersama produk sel lain akan mengeluarkan cacing dewasa. Penelitian ini bertujuan untuk mengetahui peran basofil, TNF-α dan IL-9 pada infeksi STH. Total Subyek penelitian ini adalah 40 orang petani, yang terdiri dari 20 orang terinfeksi dan 20 orang tidak terinfeksi di dusun Sumberagung dan Janti di Kabupaten Kediri kemudian. Hasil : Terdapat perbedaan kadar TNF-α pada petani terinfeksi STH dan tidak terinfeksi sedangkan jumlah basofil dan kadar IL-9 tidak terdapat perbedaan. Kesimpulan : ada perbedaan TNF-α pada petani terinfeksi STH dan tidak terinfeksi sedangkan jumlah basofil dan kadar IL-9 tidak terdapat perbedaan. Kata kunci : STH, basofil, TNF-α, IL-9
Diabetes Melitus merupakan penyakit degeneratif, dengan ciri hiperglikemia akibat kelainan sekresi insulin, kerja insulin atau kedua-duanya. Penelitian ini bertujuan untuk mengetahui perbedaan glukosa serum dan plasma NaF dengan penundaan 12 jam pada pasien diabetes melitus. Metode yang digunakan cross-sectional, dengan jumlah sampel sebanyak 60 responden, diambil secara purposive sampling. Kadar glukosa serum dan plasma NaF dengan penundaan 12 jam diperiksa dengan metode GOP-PAP dan sebagai pembanding adalah glukosa serum segera diperiksa. Darah dimasukkan dalam 3 tabung berbeda, darah segera diperiksa, glukosa serum dan plasma NaF dengan penundaan 12 jam. Hasil penelitian ditemukan perbedaan glukosa serum dan plasma NaF dengan penundaan 12 jam pada pasien diabetes melitus p > 0,05(p = 0,000 dan 0,118). Kesimpulan dari penelitian ini ditemukan perbedaan bermakna antara glukosa serum dan plasma NaF dengan penundaan 12 jam pada pasien diabetes melitus.
The COVID-19 pandemic has had a huge impact on the way people live. Efforts that can be made to prevent the transmission of COVID-19 include increasing the body's immune system by consuming herbs from a mixture of ginger and turmeric. The chemical content of herbs and turmeric is believed to be able to increase the body's immune system and have the same efficacy when consuming vitamin C. To facilitate the presentation process, these ginger and turmeric rhizomes need to be made in instant herbal preparations. For this reason, this community service activity was carried out to provide knowledge on the processing of ginger and turmeric into instant herbal medicine so that they could provide added value to the residents of Kemaduh village, Nganjuk. This activity was carried out by providing training to 8 residents who were willing and then the results of the instant herbal medicine were distributed to the residents to get an assessment both in terms of appearance and taste. Of the 8 participants who took part in the training on processing ginger and turmeric instant herbs, it was found that 100% were very knowledgeable about processing ginger and turmeric instant herbs. And for the assessment of taste, from 14 respondents 64.29% answered good and 35.71% answered very well. And in terms of appearance, 21.43% answered well and 78.57% answered very well. Based on the results above, it is known that the training participants understand the method of making ginger and turmeric instant herbal medicine and the public likes the results of this instant herbal medicine.Pandemi covid-19 memberikan pengaruh yang sangat besar terhadap pola hidup manusia. Upaya yang dapat dilakukan untuk mencegah penularan covid-19 ini diantaranya meningkatkan sistem imun tubuh dengan mengkonsumsi jamu dari campuran jahe dan kunyit. Kandungan kimia pada jamu dan kunyit diyakini dapat meningkatkan sistem imun tubuh dan khasiatnya sama saat mengkonsumsi vitamin C. untuk memberi mempermudah dalam proses penyajian maka rimpang jahe dan kunyit ini perlu dibuat dalam sediaan jamu instan. Karena inilah kegiatan pengabdian masyarakat ini dilakukan untuk memberi pengetahuan terhadap pengolahan jahe dan kunyit menjadi jamu instan sehingga dapat memberi nilai guna lebih terhadap warga desa Kemaduh, Nganjuk. Kegiatan ini dilakukan dengan memberi pelatihan kepada 8 orang warga yang bersedia dan selanjutnya hasil dari jamu instannya di bagikan kewarga untuk mendapatkan penilaian baik dari segi penampilan maupun rasanya. Dari 8 peserta yang ikut pelatihan pengolahan jamu instan jahe dan kunyit didapatkan 100% sangat paham dalam hal pengolahan jamu instan jahe dan kunyit. Dan untuk penilaian terhadap rasa, dari 14 responden 64,29% menjawab baik dan 35,71% menjawab sangat baik. Dan untuk dari segi penampilan 21,43% menjawab baik dan 78,57% menjawab sangat baik. Berdasarkan hasil diatas diketahui, peserta pelatihan sangat memahami metode pembuatan jamu instan jahe dan kunyit dan masyarakat suka dengan hasil olahan jamu instan ini.
Carp (Cyprinus carpio L.) is a widely cultivated Indonesian fishery commodity. The increasing demand for carp can be used as an opportunity to increase the production and income of farmers and fulfill the target of increasing the nutrition of the residents. The heat shock method is one method that is often used because the process is simpler than the others. Polyploidy analysis was carried out by counting the number of nucleoli in fish resulting from polyploidization. The results of the ploidization analysis of carp in this study showed that there were variations in the number (frequency) of nucleoli per cell in diploid, triploid, and tetraploid fish. The body size of tetraploid fish is larger than that of triploid fish. But triploid fish have a larger body size than diploid fish. Tetraploid goldfish have a larger size and nucleus and cell contents when compared to triploids, even more so with diploids. The more the number of cells causes the volume of cells in the body to increase, so that the body size or growth of the tetraploid carp is higher. The growth of organisms is also a process of multiplying the number of cells and increasing the volume of cells.
Yellow ripe banana skin is rich in flavonoid compounds, and contains other phenolic compounds. The presence of flavonoids and other phenolic compounds in banana peels needs to be identified and tested for their activities, so as to increase the utilization of banana waste more optimally. Besides bananas also contain high epigallocatechin gallate (EGCG). EGCG is well known for its wide spectrum of biological activity as an anti-oxidative, anti-inflammatory and anti-tumor agent. The purpose of this study was to determine the potential of EGCG of plantain (Musa paradisiaca var. Raja) peel against caspase 3 through granzyme B pathway in mice (Mus musculus) sepsis model based on silico. Analysis of the potential of EGCG on mice was carried out using the application http://stitch.embl.de/. STITCH is a database of known and predicted interactions between chemicals and proteins. Interactions include direct (physical) and indirect (functional) associations, STITCH data derived from computational predictions, from the transfer of knowledge between organisms, and from interactions collected from other (primary) databases. Analysis of the mechanism of epigallocatechin gallate of plantain peel against capase 3 in sepsis mice using bioinformatics application https://www.kegg.jp/. Based on the results of the analysis it can be seen that EGCG can be used as a promising target agent candidate for plasma membrane proteins, such as epidermal growth factor receptors. In addition, action mechanisms have been demonstrated that rely on inhibition of ERK1 / 2, p38 MAPK, NF-κB, and vascular endothelial growth factors. Furthermore, EGCG and its derivatives are used in proteasome inhibition and they are involved in epigenetic mechanisms.
Waru jawa (Hibiscus tiliaceus L.) is a plant that functions as an anti-inflammatory. Compounds from the waru jawa plant, especially the bark can be grouped into alkaloids, flavonoids, triterpenoids, and steroids. The content of triterpenoids from the waru jawa stem bark was tested for their biochemical activity, so that it is expected that the bark of Javanese waru stems can be used optimally. This study aims to determine the potential of triterpenoids from waru jawa stem bark as anti-inflammatory candidates in mice (Mus musculus) rheumatoid arthritis model in silico-based. Potential analysis of triterpenoids in mice was carried out using the STITCH, which is a database of known and predicted interactions between chemicals and proteins found in living things. Interactions in question are physical and functional associations, the data contained in STITCH comes from computational predictions, transfer of knowledge between organisms, and from interactions collected from other databases. Analysis of the triterpenoid mechanism of waru jawa stem bark against rheumatoid arthritis model mice in silico-based using the bioinformatics application Kegg. Based on the results of the analysis, it can be seen that triterpenoids derived from waru jawa stem bark sources play an important role in reducing inflammation. The triterpenoids target NF-κB, leading to its downregulation. Triterpenoids have been found to have many functions, although their effective concentrations for various cellular effects may vary widely. Depending upon the dose administered, triterpenoids can induce anti-inflammatory, proliferation-arresting, apoptotic effects, cytoprotective, and tumor-differentiating.
Wabah COVID-19 telah menjadi pandemi global yang memengaruhi banyak negara, termasuk Indonesia. Pemerintah dan lembaga kesehatan telah melaksanakan berbagai langkah untuk mencegah penyebaran COVID-19. Salah satu langkah penting adalah menggalakkan kebiasaan hidup bersih dan sehat sebagai upaya pencegahan penyebaran COVID-19 di kelurahan Tamanan, Kota Kediri. Pengabdian masyarakat ini bertujuan untuk meningkatkan pemahaman masyarakat tentang kebiasaan hidup bersih dan sehat sebagai upaya pencegahan penyebaran COVID-19. Metode yang digunakan dalam pengabdian masyarakat ini adalah pendekatan partisipatif dengan melibatkan masyarakat secara aktif dalam pengumpulan data dan pelaksanaan kegiatan. Kegiatan yang dilakukan meliputi penyuluhan, demonstrasi, dan penyediaan fasilitas sanitasi. Aktivitas ini diikuti oleh 50 ibu rumah tangga selama 3 bulan, terdiri dari tiga kegiatan utama penyuluhan kesehatan tentang pola hidup bersih dan sehat untuk mencegah penularan COVID-19. Data untuk penilaian kebiasaan hidup sehat menggunakan instrumen kuesioner dan checklist sebelum dan sesudah pelatihan. Pengetahuan, sikap dan psikomotor ibu rumah tangga dalam penyebaran penularan COVID-19 setelah diberikan pelatihan kebiasaan hidup sehat selama 3 bulan mengalami peningkatan. Penilaian dilakukan dengan membandingkan hasil pre-test dan post-test pelatihan peserta. Setelah mengikuti pelatihan, sebagian besar kemampuan peserta masuk kategori tinggi pada aspek pengetahuan (76%), aspek sikap (82%) dan aspek aspek psikomotor (92%). Berdasarkan hasil pengabdian ini, dapat disimpulkan bahwa penggalakan kebiasaan hidup bersih dan sehat dapat menjadi upaya efektif dalam pencegahan penyebaran COVID-19 di kelurahan Tamanan, Kota Kediri.
Crossing over is the occurrence of disconnection and reconnection followed by a reciprocal exchange between the two chromatids in a bivalent form. The crossing event will produce parental type and recombinant type. In the event of crossing over, various factors can influence it. These factors can be due to internal and external. Recently, various factors have been reported that influence the incidence of crossing over. These factors include age, temperature, radiation, and changes in chromosome structure. This research is a type of experimental research that uses a randomized block design. Randomized block design by crossing D. melanogaster strains ?N>< ?bcl and ?N>< ?ym and their reciprocals. From the results of this cross (F1) then cross again ?N with the recessive male (from stock) then observe the phenotype of the offspring (F2) and calculate the results of the offspring. The F2 ?N crosses were treated with age variations, namely 0, 3, 6, 9, 12, 15, and 18 days. Based on the results of these crosses, the derived strains that appeared in the F2 crosses showed the phenomenon of crossing over with the influence of the age of the female and the type of strain on crossing events. the frequency or value of crossing over (formation of recombinants) decreased with the increasing age of the female. If the age of the female affects the frequency of crossing over, then the older the female, the more likely the frequency of crossing over will decrease. However, because the data obtained were incomplete, it was not possible to know the effect of female age on the frequency of crossing over of D. melanogaster crosses ?N>< ? bcl and ?N >< ?ym and their reciprocals. The condition for crossing over is the formation of a synaptonemal complex. Age of D. melanogaster females has an effect on the frequency of crossing over in crosses N? >< bcl?, N? >< ym?, and their reciprocals. The older Drosophila melanogaster is, the lower the frequency of crossing over will occur. Based on this, it was necessary to cross D. melanogaster with strains N, bcl, and ym. A cross consists of ?N ><?bcl and ?N ><?ym and their reciprocals. By crossing ?N with a recessive male from the stock, then observing the F2 phenotype, it is hoped that crossing over will occur. So that you can better understand by doing the practice directly. In this case, the effect of crossing over is seen from the age of the female and the type of strain.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.