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Introduction:In recent years, the search of biologically active compounds from plants has always been of great interest to scientists looking for new sources of useful drugs against infectious diseases. In this present study we investigated quantification of total phenolic, alkaloid content and in vitro antioxidant activity of ethanol (70%), methanol, ethyl acetate and hexane extracts of Synadium grantii. Methods: The quantification of the total phenolic and alkaloid contents were estimated by taking gallic acid and atropine are as a standards, in vitro antioxidant activity was evaluated for extracts by using different free radicals (superoxide, hydroxyl and DPPH). Results: Synadium grantii methanol extract have more phenolic and ethyl acetate alkaloid content than other extracts. The selected plant extracts were produced concentration dependent percentage inhibition of different free radicals and produced maximum activity at a concentration of 1280 µg and there after the percentage inhibition were raised gradually to its maximum level with higher concentrations. Conclusion:In the present study, we found that the extracts of Synadium grantii showed good antioxidant activity. Among the four extracts, the ethyl acetate extract showed better activity than others.

Introduction: Anti-oxidants are vital substances which possess the ability to protect the body from damage caused by free radical induced oxidative stress. There is an increasing interest in natural anti-oxidants, e.g., polyphenols, present in medicinal and dietary plants, which might help prevent oxidative damage. Methods: In this present study we investigated preliminary phytochemical, total phenolic, alkaloid content and In-vitro antioxidant activity of hexane, ethyl acetate, ethanol (70%) and methanol extracts of Thespesia populnea Seeds. Results: Thespesia populnea Seeds revealed the presence of steroids, flavonoids and alkaloids, glycosides, tannins, quinones and carbohydrates. The extracts do not contain the amino acids, oils and the hexane fraction do not contain triterpenes and tannins. The ethyl acetate extract have more phenolic content than other extracts and the methanolic extract has more alkaloidal than other extracts. The selected plant extracts were produced concentration dependent percentage inhibition of superoxide radical and produced maximum activity at a concentration of 160 µg and there after the percentage inhibition were raised gradually to its maximum level with higher concentrations. Conclusion: Among the four types of T.populnea seeds extracts, the methanolic extract showed better activity than aqueous extracts at 160 µg concentrations.

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