Evaluation of in-vitro antibacterial activity and anti-inflammatory activity for different extracts of Rauvolfia tetraphylla L. root bark

Rao, Battu Ganga; Rao, P. Umamaheswara; Rao, E. Sambasiva; Talluri, Mallikarjuna Rao

doi:10.1016/s2221-1691(12)60235-4

Cited by 18 publications

(12 citation statements)

References 10 publications

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“…Similar results were reported in R. tetraphylla (Suresh et al, 2008), (Kumar et al, 2010) and (Rao et al, 2012), has revealed in vitro antibacterial activities of root bark extract in R. tetraphylla.…”

Section: Discussionsupporting

confidence: 88%

Phytochemical Screening and Antimicrobial Activity of Leaf, Stem, Root and their Callus Extracts in Rauwolfia tetraphylla

Rohela¹,

Bylla²,

Korra³

et al. 2016

IJAB

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Phytochemical screening and Antimicrobial studies were carried out in a medicinally important plant species, Rauwolfia tetraphylla. The aim of the present study was to screen leaf, stem and root extracts and their callus (NaCl stressed & unstressed) extracts of R. tetraphylla (24 months old) for the qualitative analysis of phytochemicals like alkaloids, flavonoids, saponins, tannins and gums and mucilages and to study antibacterial and antifungal activities in these extracts. Phytochemical screening revealed that Alkaloids are major phytochemicals in leaf, stem and root extracts of R. tetraphylla (24 months old). In antimicrobial activity studies, maximum bacterial growth inhibition zone (25.0 ± 2.4 mm) was observed in methanol based leaf extracts against Staphylococcus aureus and maximum fungal growth inhibition zone (22.0 ± 2.1 mm) was observed in Fusarium oxysporum in methanol based root extracts. In NaCl stressed callus extracts both antibacterial and antifungal activities were observed but the results were not comparable to extracts of in vivo plant based leaf, stem and roots.

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Section: Discussionsupporting

confidence: 88%

Phytochemical Screening and Antimicrobial Activity of Leaf, Stem, Root and their Callus Extracts in Rauwolfia tetraphylla

Rohela¹,

Bylla²,

Korra³

et al. 2016

IJAB

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“…The total root extracts exhibits a variety of effects viz., sedation, hypertension, brodyeardia, myosis, ptosis and tremors which are typical of reserpine (Mulliken and Crofton, 2008;Selvam, 2012). Pharmacological studies demonstrate that Rauwolfia possesses cardiovascular (Anitha and Kumari, 2006), antihypertensive (Von Poser et al, 1990), antiarrhythmic (Kirillova et al, 2001), antiinflammatory (Rao et al, 2012), antipyretic (Amole and Onabanjo, 1999), antidiabetic (Campbell et al, 2006), anticancer (Bemis et al, 2006), hypoglycaemic and hypolipidemic (Qureshi et al, 2009), hepatoprotective (Gupta et al, 2006), sedative (Weerakoon et al, 1998), antihistaminase (Sachdev et al, 1961), mosquito larvicidal (Das and Chandra, 2012), antidiarrhoeal (Ezeigbo et al, 2012) and antimicrobial activities (Ahmed et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

<i>In-vitro</i> Antimicrobial Activity of Roots of <i>Rauwolfia serpentina</i> L. Benth Kurz

Owk¹,

Lagudu²

2016

Not Sci Biol

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Microbial pathogens develop resistance to antibiotics after repeated administration during the treatment of infectious diseases. Therefore, it is necessary to find alternative antimicrobial drugs and the present trend is focused on medicinal plants. The hereby research work was carried out to investigate the antimicrobial activity of solvents as well as aqueous extracts of Rauwolfia serpentina roots. The extracts were tested against Bacillus subtilis, Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, Micrococcus luteus, Pseudomonas aeruginosa, Proteus vulgaris, Staphylococcus aureus, Streptococcus pneumoniae, Aspergillus niger, Candida albicans and Saccharomyces cerevisiae by agar well diffusion method. It was observed that methanol extract showed the highest antimicrobial activity against multi drug resistance S. aureus at 100 mg/ml concentration, while S. aureus was the most susceptible bacterium to all extracts. However, E. faecalis, M. luteus and S. pneumoniae were also susceptible to the experimented solvents and extracts. On the other hand, K. pneumoniae was resistant against the solvent and aqueous extracts. The present study suggested that methanol extracts of R. serpentina roots would be helpful in treating diseases caused by human pathogenic bacteria and fungi. In particular, based on the results obtained in the current experiment, it can be recommended for the control of infectious Gram-positive bacteria.

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“…Determination of antibacterial activity: The perforated diffusion method was used to measure the degree of antibacterial activity 19 . Initially, 18 mL of the nutrient agar was added to each petri dish.…”

Section: Methodsmentioning

confidence: 99%

Optimization of Ultrasonic- and Microwave-Assisted Extraction of Antibacterial Compounds from Amomum tsao-ko Fruit

Ma¹,

Qiu²,

Chen³

et al. 2014

Asian J. Chem.

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Amomum tsao-ko Crevost et Lemaire (Zingiberaceae) is widely distributed in Southwest China. Its dried fruit is usually used as a form of traditional Chinese medicine for malaria, throat infections, abdominal pain, stomach disorders, dyspepsia, nausea, vomiting and diarrhea. Amomum tsao-ko is commercially important in the Southeast Asian market as a spice that provides a distinct flavor. Previous studies have demonstrated the biological and pharmacological activities of Amomum tsao-ko 1. Several components and bioactive substances from this plant have already been reported, including the antifungal bicyclic nonanesisotsaokoin, its isomer tsaokoin, the antioxidant catechins, the antiproli-ferative bicyclononane aldehydes and the cytotoxic tsaokoaryloneall 2-5. The essential oil from Amomum tsao-ko is cytotoxic to HepG2, Hela, Bel-7402, SGC-7901 and PC-3 cell lines, as well as induces apoptosis in HepG2 cells 6. Moreover, its methanol extract attenuated nitric oxide production in lipopolysaccharide-simulated BV2 microglia, whereas its ethyl acetate extract produced an oral trigeminal effect 7,8. The fat-soluble polar components of Amomum tsaoko contain an active component associated with decreased plasma glucose and thiobarbituric acid reactive substances (TBARS) concentrations in mice 9. The ethanolic extract of Amomum tsao-ko had high antibacterial activity for Staphylococcus aureus and Escherichia coli 10 .

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Evaluation of in-vitro antibacterial activity and anti-inflammatory activity for different extracts of Rauvolfia tetraphylla L. root bark

Cited by 18 publications

References 10 publications

Phytochemical Screening and Antimicrobial Activity of Leaf, Stem, Root and their Callus Extracts in Rauwolfia tetraphylla

Phytochemical Screening and Antimicrobial Activity of Leaf, Stem, Root and their Callus Extracts in Rauwolfia tetraphylla

<i>In-vitro</i> Antimicrobial Activity of Roots of <i>Rauwolfia serpentina</i> L. Benth Kurz

Optimization of Ultrasonic- and Microwave-Assisted Extraction of Antibacterial Compounds from Amomum tsao-ko Fruit

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