Quantification of phytochemical constituents in vitro antioxidant activity of Synadium grantii

Dasari, Narender Prasad; Rao, Battu Ganga; Rao, E. Sambasiva; Talluri, Mallikarjuna Rao

doi:10.5530/ax.2012.2.2.12

Cited by 7 publications

(7 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The findings of the present study are in accordance with those of Dasari et al , which showed that S. grantii has phenolic compounds and the ability to scavenge free radicals [27]. Our findings show that the stem bark of S. grantii had inhibitory activity regarding the myeloperoxidase enzyme and scavenger action against severe oxidants such as O 2…”

Section: Resultssupporting

confidence: 93%

Chemical and Pharmacological Investigation of the Stem Bark of Synadenium grantii

et al. 2014

View full text Add to dashboard Cite

Based on the fact that Synadenium grantii is used in folk medicine for the treatment of peptic ulcers and inflammatory diseases, this work describes its chemical and pharmacological properties. Pharmacological investigation of the crude bark extract showed a high antioxidant activity over several scavenger systems, such as 2,2'-azino-bis (3-ethylenebenzothiazoline-6-sulfonic acid)• +, 1-diphenyl-2-picrylhydrazyl•, O2 • - , and HOCl, as well as an enzymatic system with human myeloperoxidase and an ex vivo hemolysis system. Furthermore, the oral administration of the crude bark extract was able to reduce carrageenan-induced rat paw edema as effectively as ibuprofen. These biological activities may be associated with the presence of flavonoids and terpenes, as revealed by HPLC and NMR analyses of the crude stem bark extract. The phytochemical investigations in this study resulted in the isolation of friedelin and 3β-friedelinol for the first time, while euphol and lanosterol were also isolated.

show abstract

Section: Resultssupporting

confidence: 93%

Chemical and Pharmacological Investigation of the Stem Bark of Synadenium grantii

et al. 2014

View full text Add to dashboard Cite

show abstract

“…The medicinal properties of plants have been investigated in recent scientific developments throughout the world, due to their potent biological activities and economic viability (Dasari et al, 2012). Several studies describe such biological activities of plants as antibacterial, antifungal, and antiviral.…”

mentioning

confidence: 99%

Potential Use of Buddleja Thyrsoides for the Control and Prevention of American Foulbrood Disease in Honey Bees

Boligon

Piana

Brum

et al. 2014

Journal of Apicultural Science

View full text Add to dashboard Cite

a b s t r a c t Paenibacillus larvae is the causative agent of american foulbrood (afb), a severe disease that affects the larvae of the honeybees. the use of plant extracts are considered to be an alternative way of controlling the disease. in this study, the in vitro antimicrobial activity of buddleja thyrsoides lam. against the Paenibacillus species, including P. larvae, was evaluated. in mueller-hinton broth, the minimal inhibitory concentration (miC) was assessed using the microdilution method. all Paenibacillus species were sensitive to the crude extract and the fractions of b. thyrsoides. the ethyl acetate (ea) fraction showed a better result with miC values of 1.68 -3.36 mg/ml, followed by butanolic (bU) (miC = 2.18 -6.54 mg/ml), dichloromethane (dCm) (7.40 -14.80 mg/ml), and crude extract (Ce) (7.51 -16.90 mg/ml). the toxic effect of the Ce and fractions of b. thyrsoides against bees were also evaluated using the spraying application method with the same concentrations of miCs. bee mortality was evident in treatment with dCm fractions only, while Ce, ea, and bU extracts showed no toxic effects after 15 days of observation. furthermore, phenolic acids, tannins, and flavonoids were identified and quantified by highperformance liquid chromatography (hPlC), and may be partially responsible for the antimicrobial properties observed. these results show, for the first time, that b. thyrsoides might be a natural alternative for the prevention/control of afb.

show abstract

“…Antioxidant activity is commonly attributed to phenolic compounds, however, spearson correlation analysis revealed a correlation=0.58 (n-12, p=0.048) between alkaloid content and antioxidant activity. Plants from the euphorbiaceae family, such as S. rautanenii have been found to confer antineoplastic activities (Soetan and Aiyelaagbe, 2009), antioxidant activity (Dasari et al, 2012) and this was attributed to the presence of phenolic acids. The phytochemical profile (Table 3) and quantification (Figure 1) suggests that the use of these plants in the traditional setting is rational and may be useful as an anticancer traditional alternative treatment (Wahab et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Palliative treatment of cancer in resource poor settings: Traditional medicine perspective

Dushimemaria¹,

Mumbengegwi²

2015

J. Pharmacognosy Phytother.

View full text Add to dashboard Cite

This study aimed to determine the suitability of ethnomedicinal plants as a suitable option for palliative care of cancer in Namibia. To achieve this, key informant interviews were conducted in central and northern parts of Namibia on the use of ethnomedicinal plant products for palliation of cancer. Information from surveys on the medicinal use of plants in Oshikoto and Zambezi regions of Namibia for ailments such as tumors were used to select plants for phytochemical analysis. Plants were collected and extracts were prepared for analysis for phytochemical detection using thin layer chromatography, anti-protease, antioxidant and phytochemical quantification of Colophospermum mopane and Shinziophyton rautanenii plants. Findings from key informant interviews revealed pain management for cancer patients was the primary form of disease management at health care facilities in contrast to an established holistic palliative care system. As a result, patients looked towards alternative treatment from ethnomedicinal plant sources in their bid to palliate cancer and seek hope. Phytochemical analysis of indigenous plants collected, revealed the presence of class compounds such as flavonoids, alkaloids, triterpenes, coumarins and anthraquinones as well as biological activities such as anti-protease, antioxidant properties. In conclusion, phytochemical properties of the six plants were consistent with their ethnomedicinal use, making them a suitable option for treatment of cancer in resource poor settings such as Namibia. Further studies are required to evaluate safety and mode of action.

show abstract

Quantification of phytochemical constituents in vitro antioxidant activity of Synadium grantii

Cited by 7 publications

References 10 publications

Chemical and Pharmacological Investigation of the Stem Bark of Synadenium grantii

Chemical and Pharmacological Investigation of the Stem Bark of Synadenium grantii

Potential Use of Buddleja Thyrsoides for the Control and Prevention of American Foulbrood Disease in Honey Bees

Palliative treatment of cancer in resource poor settings: Traditional medicine perspective

Contact Info

Product

Resources

About