The purpose of this research was to study the possibility of using of food products from a mixture of Hypericum perforatum (HP) and Rhodiola rosea (RR) for the stimulation of the body´s compensatory responses to the conditions of high and low temperatures. Experiments have been conducted on experimental animals (150 white mongrel rats) in accordance with generally accepted methodological approaches. Antioxidant effects in the organism of white rats have been studied at the initiation of the processes of lipid peroxidation by the introduction of carbon tetrachloride. We were determined the products of lipid peroxidation (diene conjugates, hydroperoxides of lipids, malonic dialdehyde) for the evaluation of antioxidant effect in accordance with generally accepted methodological approaches. Researches of cold and heat adaptation reactions of experimental animals have been conducted by using the model of a long cold and heat action with appropriate climatic chambers. It was established experimentally that in doses of 150-300 mg/kg daily of the studied mixture has a strong antioxidant effect in the conditions of cold and heat stress on warm-blooded organism. The research allows to recommend a mixture of HP and RR as а regulator of adaptive reactions of the organism when exposed to low and high temperatures.
In the review of the literature, data on the possibility of adaptation reactions of a warm-blooded organism to cold and heat stress are described in detail. The scientific experience of application of adaptogenic products in the correction of overheating and cooling of the organism is discussed. The theoretical problems of the toxic effect of the temperature factor of the environment on cognitive abilities of laboratory animals and humans are revealed. The article presents the historical data about the study of these issues over the last 50 years.
Контактная информация Екатерина Андреевна Литовченко, канд. мед. наук, ассистент кафедры общей гигиены, Федеральное государственное бюджетное образовательное учреждение высшего образования «Амурская государственная медицинская академия» Министерства здравоохранения Российской Федерации, 675000, Россия, г. Благовещенск, ул. Горького, 95.
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