Objective.
To study the possibility of transferring multidrug resistant microorganisms through healthcare workers’ cell phones between medical institutions in Khabarovsk.
Materials and Methods.
It was a comparative prospective study to assess contamination of cell phones with multidrug-resistant microorganisms in a population (n = 30) and among intensive care unit (ICU) physicians (n = 60) in medical institutions. Antimicrobial susceptibility testing was performed by disc-diffusion method. A total of 514 healthcare workers from medical institutions of Khabarovsk were interviewed. The study enrolled 58.9% (n = 303) of physicians and 41.1% (n = 211) of nurses.
Results.
Microbial contamination of the physicians’ cell phones with extensively drug-resistant (16.7%; n = 10) and pandrug-resistant strains (6.7%; n = 4) was found to be significantly higher than that in the population.
Conclusions.
Working in several medical institutions and the healthcare workers’ personal articles can be the ways of spreading resistant microorganisms.
Lithospermum erythrorhizon is a promising plant, its roots synthesize biologically active substances (BAS): naphthoquinone shikonin and its esters, which have antimicrobial, wound healing, anti-inflammatory, antioxidant, antineoplastic and other types of pharmacological action. The industrial harvesting of Lithospermum erythrorhizon is difficult due to its limited area, but there is a possibility to grow its cell culture using the biotechnological method, which opens up great prospects for the further isolation of these BAS. Previously, we proposed a composition and a technological scheme for the manufacture of polymeric films containing shikonin and its esters, isolated from a culture of Lithospermum erythrorhizon cells. This study is devoted to the development of approaches to the qualitative analysis of polymeric films. Three directions of qualitative analysis are considered: evaluation of external signs, determination of technological parameters of films, confirmation of the presence of naphthoquinones. The criteria of quality and methods of analysis in each direction have been determined. The presence of shikonin and its derivatives in the polymeric films was confirmed by color reactions, thin layer chromatography and spectrophotometry.
Objective: Comparative evaluation of the effect of regulatory peptides on lipid peroxidation in brain tissue after traumatic brain injury (TBI).Methods: Reproductive Wistar male rats were divided into 3 groups: the first group received 0.1 mg/kg of “Selang” peptide solution (Thy-Lys-Pro-Arg-Pro-Gly-Pro) within 5 days after the experimental traumatic brain injury, the second group received 0.1 mg/kg AGAPGP peptide (Arg-Gly-Arg-Pro-Gly-Pro), the third (control) – 0.9% sodium chloride solution. Drugs were administered retroperitoneally.Results: According to chemiluminescence in the biomaterial taken from rats of the first group, indicators of oxidative stress were less pronounced.Conclusions: The Selang has a more pronounced antioxidant effect on brain tissue after traumatic brain injury compared with the AGAPGP peptide.
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