Traditionally, the drinking of large amounts of alcoholic beverages has been considered a common predisposing or precipitating cause of gout (1). Thus far, however, the possibility of a relationship between ethanol and urate metabolism does not seem to have been investigated. In an attempt to evaluate a possible effect of ethanol on uric acid metabolism, we have studied serum uric acid levels in patients intoxicated with ethanol. Having observed that ethanol leads to an elevation of serum uric acid concentration, we investigated the mechanisms of this effect.
No detectable abnormalities or changes in the post heparin plasma lipoprotein lipase (LPL) activity were found in fifteen “insulin independent” (stable) or sixteen “insulin dependent” (labile) diabetics, with or without hyperlipemia, in four patients with ketoacidosis and hyperlipemia both during the acute phase and after recovery, in two subjects with insulin induced hypoglycemia, and in two patients with gross hyperlipemia and diabetes during marked fluctuations in lipid levels in one, and during correction of the hyperlipemia in the other.
Abnormalities in the LPL system, as reflected in the post heparin plasma LPL activity, appear to play a minor role, if any, in the pathogenesis of diabetic hyperlipemia in man.
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