Lipoprotein Lipase Activity in Patients with Diabetes Mellitus, with and without Hyperlipemia

Abstract

No detectable abnormalities or changes in the post heparin plasma lipoprotein lipase (LPL) activity were found in fifteen “insulin independent” (stable) or sixteen “insulin dependent” (labile) diabetics, with or without hyperlipemia, in four patients with ketoacidosis and hyperlipemia both during the acute phase and after recovery, in two subjects with insulin induced hypoglycemia, and in two patients with gross hyperlipemia and diabetes during marked fluctuations in lipid levels in one, and during correction of the hyperlipemia in the other. Abnormalities in the LPL system, as reflected in the post heparin plasma LPL activity, appear to play a minor role, if any, in the pathogenesis of diabetic hyperlipemia in man.

Effect of Fat Cell Size, Restrictive Diet and Diabetes on Lipoprotein Lipase Release by Human Adipose Tissue

“…On the other hand this cell size effect can be com- weil to the nutritional regulation admitted for LPL (Robinson and Wing 1970). The present studies do not indicate which element of the diet, carbohydrate (1970) cyte glucose metabolism (Sa/ans et al 1974).…”

Post-Heparin Lipolytic Activity and Tissue Lipoprotein Lipase Activity in the Alloxan-Diabetic Rat

“…Bagdade, Porte & Bierman (1968) reported a fall in PHLA associated with high plasma triglyceride levels after withdrawal of insulin in a group of insulin-requiring diabetics. Jones, Plotkin & Arky (1966), on the other hand, found no difference between PHLA in control subjects and insulin-requiring diabetics with and without hypertriglyceridaemia. They also found normal levels of PHLA in diabetics presenting with diabetic ketosis, which did not rise when this state had been corrected.…”

Postheparin Plasma Lipoprotein Lipase and Hepatic Lipase in Diabetes Mellitus: Relationship to Plasma Triglyceride Metabolism

“…of the corresponding control group), and five additional patients had LPL activity in a low normal range. Of these 13 diabetics with moderate or (9) 3.56 ± 0.21 (12) 3.68 ± 0.16 (7) 4.12 ± 0.35 (20) VLDL-TG Fractional turnover hr." 1 0.271 ± 0.071: (7)-0.344 ± 0.06 (7) 0.366 ± 0.12 (7) 0.432 ± 0.07 (14)f Turnover rate mg./hr."'kg.…”