Post-Heparin Lipolytic Activity and Tissue Lipoprotein Lipase Activity in the Alloxan-Diabetic Rat

Elkeles, R.S.; Williams, E.

doi:10.1042/cs0460661

Cited by 2 publications

(1 citation statement)

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“…Administration of isopropanol, although affecting heart and adipose tissue LLA, does not modify the blood plasma PHLA. This finding supports the view of Elkeles & Williams (1974) that PHLA does not reflect tissue LLA. As administration of glucose results in enhanced plasma PHLA and as administration of isopropanol is followed by a rise in blood glucose, the lack of enhancement of PHLA in isopropanol-treated rats is surprising.…”

Section: Discussionsupporting

confidence: 90%

Modifications of Plasma Post-Heparin Lipolytic Activity and Tissue Lipoprotein Lipase Activity Induced in the Rat by Acute Administration of Ethanol or Propan-2-ol

Giudicelli

Nordmann

1975

Clinical Science

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1. The oral administration of propan-2-ol [isopropanol; 100 mmol (6 g)/kg body weight] or ethanol [130 mmol (6 g)/kg body weight] to starved rats produced no change in plasma post-heparin lipase activity (PHLA) compared with that observed in 154 mmol/1 sodium chloride (saline)-treated rats. 2. An increase of adipose tissue lipoprotein lipase (LLA) and a decrease of heart LLA occurred in isopropanol-treated animals, whereas no significant changes were found in these activities after ethanol administration. 3. Since administration of isopropanol produces hyperglycaemia, observations were also made in rats receiving glucose infusion rather than saline. In these animals a rise in PHLA and adipose tissue LLA, and a fall in heart LLA, occurred. 4. It is suggested that the changes in tissue LLA produced by isopropanol are mediated by the rise in blood glucose.

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Section: Discussionsupporting

confidence: 90%