Studies of alcoholic hyperlipemia and its mechanism

Losowsky, M. S.; Jones, Don P.; Davidson, Charles S.; Cs, Lieber

doi:10.1016/0002-9343(63)90241-9

Cited by 148 publications

(17 citation statements)

References 22 publications

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“…High alcohol consumption is emerging as an important risk factor for hyper triglyceridemia in many populations, but was not for hypercholesterolemia (36,37). In the present study, alcohol intake was not significantly associated with total serum cholesterol, either.…”

Section: Discussioncontrasting

confidence: 69%

Relationship between Total Serum Cholesterol Level and Nutritional and Physical Staus in Nepalese Rural People.

Itoh

Kawasaki

Ogaki

et al. 1993

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryTo investigate the nutritional condition in a hilly village (Kotyang) and a suburban village (Bhadrakali) in Nepal and to clarify the possible cause of the difference in total serum cholesterol level between the two groups of villagers habitually eating low fat diets, we carried out a nutrition survey using the 24-h recall method and blood sampling in 403 subjects (204 men and 199 women) in the hilly village and 466 (244 men and 222 women) in the suburban village. Total serum cholesterol was statistically significantly lower in the hilly villagers than in the suburban villagers for both sexes, but HDL-cholesterol was not. In both villages, 82% of the total energy was taken from carbohydrate, 7-8% from fat and 10% from protein. Energy, protein, fiber, potassium, magnesium, mono unsaturated fatty acid, polyunsaturated fatty acid, and vitamin A in the hilly villagers were significantly higher than those in the suburban villag ers. Total serum cholesterol was significantly associated with age and body fat percentage, suggesting that total serum cholesterol level was not directly associated with total fat intake in these Nepalese people.

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Section: Discussioncontrasting

confidence: 69%

Relationship between Total Serum Cholesterol Level and Nutritional and Physical Staus in Nepalese Rural People.

Itoh

Kawasaki

Ogaki

et al. 1993

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…In this regard Losowsky, Jones, Davidson, and Lieber (38) have recently observed lower serum lipoprotein lipase levels in some subjects given ethanol. b) In the face of increased mobilization and increased triglyceride formation in the liver, a small but definite interference of hepatic triglyceride release might still permit a relative elevation of plasma triglycerides.…”

Section: Resultsmentioning

confidence: 92%

Studies on the Pathogenesis of the Ethanol-induced Fatty Liver. II. Effect of Ethanol on Palmitate-1-C14 Metabolism by the Isolated Perfused Rat Liver*

Schapiro¹,

Drummey²,

Shimizu³

et al. 1964

J. Clin. Invest.

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In man and in the experimental animal, a fatty liver can result from acute or chronic ethanol ingestion. In the rat an increase in liver lipid occurs either after a single intoxicating dose of ethanol or after the chronic administration of this drug (2, 3). The lipid that accumulates in the liver under these conditions is predominantly in the form of triglycerides (4).The production of a fatty liver would appear to involve one or more of five possible mechanislms: a) increased mobilization of fatty acids from the peripheral adipose depots to the liver, b) increased de novo synthesis! of fatty acids by the liver, c) decreased hepatic catabolism (e.g., oxidation) of fatty acids, d) increased or preferential esterification of fatty acids to triglycerides, or e) a decreased release of lipid from the liver. In considering these mechanisms, it should be noted that studies by Mallov (5) and by Brodie and Maickel (4) have demonstrated an increased mobilization of plasma free fatty acids after relatively large doses of ethanol; this effect is apparently mediated through hypophyseal-adrenal pathways and the sympathetic nervous system (4). Furthermore, the fatty liver produced by ethanol contains large amounts of linoleic acid that is stored in the adipose tissue but not synthesized by mammalian liver (6). Lieber and Schmid (7) have observed that ethanol stimulates

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“…It has been postulated that fat accumulation could result from a decrease in lipoprotein release from the liver (32). Although this possibility has not been ruled out, the fact that a fatty liver was observed simultaneously with the development of hyperglyceridemia ( Figure 5) and that alcohol has been shown previously to produce hyperglyceri-demia (1,5,17,29,33) suggests that decreased hepatic glyceride release does not represent a primary cause for fatty liver development, at least not during the initial period.…”

Section: Discussionmentioning

confidence: 98%

Effects of Prolonged Ethanol Intake: Production of Fatty Liver Despite Adequate Diets*

Lieber¹,

Jones²,

DeCarli³

1965

J. Clin. Invest.

557

157

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Studies of alcoholic hyperlipemia and its mechanism

Cited by 148 publications

References 22 publications

Relationship between Total Serum Cholesterol Level and Nutritional and Physical Staus in Nepalese Rural People.

Relationship between Total Serum Cholesterol Level and Nutritional and Physical Staus in Nepalese Rural People.

Studies on the Pathogenesis of the Ethanol-induced Fatty Liver. II. Effect of Ethanol on Palmitate-1-C14 Metabolism by the Isolated Perfused Rat Liver*

Effects of Prolonged Ethanol Intake: Production of Fatty Liver Despite Adequate Diets*

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