Effects of insulin on triglyceride and free fatty acid metabolism in man

Jones, Don P.; Arky, Ronald A.

doi:10.1016/s0026-0495(65)80010-5

Cited by 35 publications

(11 citation statements)

References 11 publications

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“…Analogous behavior, on the other hand, has been reported by J onhs and A rky [9] in the normal during prolonged administration (24 h) of insulin.…”

Section: Discussionsupporting

confidence: 83%

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Glycolipid Modifications during Peritoneal Dialysis in Patients with Chronic Renal Failure

Zuliani¹,

Novarini²,

Bonetti³

et al. 1976

Nephron

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Ten patients with progressive CRF were studied for the major indices of glycolipid metabolism during the first application of peritoneal dialysis. From the 2nd hour the concentration of dialysis fluid is 4.5 g%, while the electrolyte content is unchanged. During treatment a constant increase of glycemia and insulinemia with a fall of plasma-free fatty acids and serum triglycerides was observed. The authors attribute such modifications to hyperglycemia and consequently to the high glucose of the dialysis bath.

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“…Analogous behavior, on the other hand, has been reported by J onhs and A rky [9] in the normal during prolonged administration (24 h) of insulin.…”

Section: Discussionsupporting

confidence: 83%

“…The difference in behavior can be interpreted as being due to the acute effect of hyperinsulinemia [9] in the first hours, more evident at the hepatic level, with esterification of FFA and synthesis of TG [17]. In the second period, the phenomenon becomes more complex and not easily interpreted.…”

Section: Discussionmentioning

confidence: 99%

Glycolipid Modifications during Peritoneal Dialysis in Patients with Chronic Renal Failure

Zuliani¹,

Novarini²,

Bonetti³

et al. 1976

Nephron

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“…A positive correlation between plasma triglyceride and insulin levels has been found in man (1)(2)(3) while infusion of insulin (4) or tolbutamide (5) in fasted humans has been accompanied by falls in the triglyceride concentration. Triglyceride levels may also be lowered by feeding glucose (6) through mechanisms which may involve enhanced production of insulin and suppression of FFA turnover.…”

Section: Introductionmentioning

confidence: 94%

Diurnal fluctuations in triglyceride, free fatty acids, and insulin during sucrose consumption and insulin infusion in man

Barter¹,

Carroll²,

Nestel³

1971

J. Clin. Invest.

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A B S T R A C T Serial changes in circulating triglyceride, free fatty acids (FFA), insulin, and glucose have been measured in human subjects fed sucrose as the sole source of calories for 2-or 3-day periods. The sucrose was given either during the day with overnight fasting (19 subjects) or as continual 3-hour meals during the day and night (seven subjects). Insulin was infused overnight in five additional subjects on the day-feeding regimen to determine the effect on triglyceride concentration.The concentration of triglyceride increased during the study in all subjects, but there was a clear diurnal pattern in the response which was present even in the continual feeding studies. The rise in triglyceride occurred mainly overnight, and during the day there was frequently a fall in the concentration. The overnight increase was significantly less when insulin was infused. There were also diurnal fluctuations in FFA and insulin in both daytime and continual feeding regimens. The plasma FFA, like triglyceride, rose during the night and fell during the day while the insulin rose during the day and fell overnight.Separate statistical analysis of the daytime and overnight changes revealed that the changes in triglyceride were significantly but negatively correlated with changes in insulin during both periods. The changes in triglyceride and FFA were positively correlated during the day but not significantly related during the night. The data show that when sucrose is eaten for 2 or 3 days, there is a general increase in triglyceride concentration upon which are superimposed major diurnal fluctuations in the concentrations of triglyceride, insulin, and FFA. It is suggested that the highly significant inverse relationship between changes in triglyceride and insulin may be mediated through an effect of insulin on triglyceride removal.

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“…There has been disagreement about the role of insulin in the regulation of VLDL triglyceride secretion, some authors taking the view that it may stimulate secretion (8,11,(13)(14)(15) and others that it may be either inhibitory (10,(16)(17)(18) or without effect (6). The present series of experiments was designed primarily to resolve this issue by observing the direct effect of insulin on VLDL triglyceride secretion.…”

mentioning

confidence: 99%

Effects of Insulin and Glucose on Very Low Density Lipoprotein Triglyceride Secretion by Cultured Rat Hepatocytes

Durrington¹,

Newton²,

Weinstein³

et al. 1982

J. Clin. Invest.

215

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A B S T R A C T The effect of insulin on hepatic triglyceride synthesis and secretion is controversial. Previously, we have described a cell culture system of adult rat hepatocytes that synthesize and secrete very low density lipoprotein (VLDL) triglycerides with small and irreproducible effects of insulin on triglyceride metabolism. To study the primary effects of insulin on hepatic triglyceride metabolism a method was developed utilizing fibronectin-coated culture dishes that allowed adhesion, spreading, and maintenance of hepatocytes for 2-3 d in the absence of serum and insulin. This culture system allowed mass measurements of both cellular and secreted VLDL triglycerides for long time periods after the addition of physiological concentrations of insulin to hormone-free culture medium. In the absence of insulin and after an initial 4 h in culture, the medium was replenished and triglyceride mass was measured at the end of 18-h incubations. VLDL triglyceride accumulated in the culture medium at a linear rate over this time-course with increasing accumulation as the medium glucose concentration was raised from 2.5 to 25 mM glucose (1.77±0.24 to 3.09±0.76 yg triglyceride/mg cell protein per h). There was no apparent significant lipolysis or hepatocellular reuptake of secreted VLDL triglycerides. In the absence of insulin cellular triglyceride levels were unchanged between 3 and 24 h in culture while insulin (50-500 gU/ml) significantly increased cellular triglyceride content at all glucose concentrations tested (0-25 mM). The addition of insulin to the culture medium progressively reduced the rate of VLDL triglyceride secretion accompanied by an increase in cellular triglyceride at insulin concentrations > 50 ,U/ml. Most or all of the observed increase in cell triglyceride content could in all experiments be accounted for by the insulin-induced inhibition of VLDL secretion. Incorporation of [2-3H]glycerol into cellular and VLDL triglycerides as a function of insulin concentration was also measured. Glycerol incorporation data at 20-22 h after plating of the cells closely paralleled the insulin-induced changes in cellular and VLDL triglyceride as determined by mass analysis. The observed effects of insulin occurred at concentrations close to the physiological range and suggest that the direct hepatic effect is to suppress VLDL secretion although the net effect in vivo will clearly reflect many additional accompanying changes.

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Effects of insulin on triglyceride and free fatty acid metabolism in man

Cited by 35 publications

References 11 publications

Glycolipid Modifications during Peritoneal Dialysis in Patients with Chronic Renal Failure

Glycolipid Modifications during Peritoneal Dialysis in Patients with Chronic Renal Failure

Diurnal fluctuations in triglyceride, free fatty acids, and insulin during sucrose consumption and insulin infusion in man

Effects of Insulin and Glucose on Very Low Density Lipoprotein Triglyceride Secretion by Cultured Rat Hepatocytes

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