Using a large consortium of undergraduate students in an organized program at the University of California, Los Angeles (UCLA), we have undertaken a functional genomic screen in the Drosophila eye. In addition to the educational value of discovery-based learning, this article presents the first comprehensive genomewide analysis of essential genes involved in eye development. The data reveal the surprising result that the X chromosome has almost twice the frequency of essential genes involved in eye development as that found on the autosomes.
catarrhalis. 16 who died were on palliative care with no treatment.12 had terminal cancer,10 end stage COPD, 3 end stage amyotrophic lateral sclerosis, 2 ischemic bowel,1 anoxic brain injury and 1 with end stage muscular disabilities. All respiratory isolates tested (103/103) 100%, were susceptible to trimehoprim/sulphametoxasole with susceptibility to levofloxacin 98/103 (95.4%), ceftazidime 27/91 (29.7%) and ticarcilin/clavulanic acid 27/101 (26.7%).Conclusion: Majority of SM respiratory infections were polymicrobial, in elderly, with significant comorbidities, terminal illnesses and associated with endotracheal tubes and traheostomies in a significant number. Most deaths could not be directly attributable to SM.
in Wiley Online Library (wileyonlinelibrary.com).In an extension of our prior work with indoles and pyrroles, the Diels-Alder chemistry of substituted 2vinylthiophenes was explored, using N-phenylmaleimide as the dienophile. The dienes were prepared from thiophene in two steps by addition to various ketones, followed by dehydration (40-60% overall yields). Although most dienes were obtained as regioisomeric mixtures, the Diels-Alder-derived products were easily purified by chromatography. The main cycloaddition pathway was endo Diels-Alder addition followed by exo ene addition of a second molecule of dienophile (19-33% yields). Several products were desulfurized with Raney nickel (48-62% yields). Unfortunately, no thiophene-derived products showed the promising biological activity of the previously reported indole analogs.
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