2007
DOI: 10.1534/genetics.107.077735
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Abstract: Using a large consortium of undergraduate students in an organized program at the University of California, Los Angeles (UCLA), we have undertaken a functional genomic screen in the Drosophila eye. In addition to the educational value of discovery-based learning, this article presents the first comprehensive genomewide analysis of essential genes involved in eye development. The data reveal the surprising result that the X chromosome has almost twice the frequency of essential genes involved in eye development… Show more

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Cited by 36 publications
(40 citation statements)
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“…Using EMS as a mutagen allowed us to identify alleles of genes for which a recent screen of lethal transposon insertions on the X chromosome (Call et al 2007) failed to detect eye phenotypes, such as fw, nej, shi, and CK1a. However, mapping lethal point mutations is much slower than mapping transposon insertion sites, and some of the mutations we generated are still unidentified.…”
Section: Discussionmentioning
confidence: 99%
“…Using EMS as a mutagen allowed us to identify alleles of genes for which a recent screen of lethal transposon insertions on the X chromosome (Call et al 2007) failed to detect eye phenotypes, such as fw, nej, shi, and CK1a. However, mapping lethal point mutations is much slower than mapping transposon insertion sites, and some of the mutations we generated are still unidentified.…”
Section: Discussionmentioning
confidence: 99%
“…Many of the items on the survey focused on learning specific subject matter, and we did not expect students to have learned many facts, but rather we expected that gains would be apparent in specifically those items addressing working in groups, on working on problems without clear solutions, on data collection/organization and interpretation, and on using this technology and related data to describe the complexity of human movement. The capacity of the RISC survey or its components to measure students increasing dexterity with these research skills has been demonstrated repeatedly in inquiry-driven science classrooms (Burnette & Wessler, 2013;Call et al, 2007;Clark et al, 2009;Jordan et al, 2014;Kowalski, Hoops & Johnson, 2016;Lopatto et al, 2008;Mader et al, 2017;Makarevitch, Frechette & Wiatros, 2015;Miller et al, 2013;Reed & Richardson, 2013;Staub et al, 2016;Sarmah et al, 2016). We hoped to identify whether there were post-course gains that might exceed the average of all students responding to the RISC that semester.…”
Section: The Risc Surveymentioning
confidence: 98%
“…Emanuel et al 155 showed that successful delivery of immunoliposomes against fibrocarcinoma antigen was highly dependent on the stage of tumor development, with superior delivery by nontargeted liposomes at all stages except the micrometastases stage. The complexities related to identifying the effective ligandreceptor interaction may help explain the observations of Call et al 156 on the lack of improved uptake of folate-targeted liposomes by target cells. Despite the success of in vitro experiments, poor accumulation of folate-targeted liposomes in KB (cells derived via HeLa contamination) tumor tissue was observed and the delivery efficiency was comparable with nontargeted liposomes.…”
Section: Conclusion: Hopes and Challengesmentioning
confidence: 99%