Mice given cycloheximide or saline were trained with a single trial. Electroconvulsive shock was administered to both groups at various times after training. Cycloheximide led to memory that decayed with time. Cycloheximide plus electroconvulsive shock produced complete amnesia at times when neither treatment alone produced amnesia. Only two types of processes appear to support memory storage in our study.
The effects of two doses of strychnine sulfate (0.125 mg/kg and 0.500 mg/kg) on mouse neural and behavioral habituation were assessed. Reliable alterations in concurrent neural (spontaneous and evoked) activity and spontaneous behavioral activity were obtained as the result of training.Neural habituation was characterized by higher frequency, lower amplitude EEG activity, reduced hippocampal theta activity, increased amplitudes in early components of visual evoked responses, and transient increases followed by progressive decreases of late component amplitudes of the visual evoked responses. Behavioral habituation appeared as decreased gross activity and changes in mouse orientation to cogent features of the test chamber.Low strychnine doses (0.125 mg/kg) reliably facilitated habituation to light flashes and produced lessened sensitivity to dishabituation stimuli. High strychnine doses (0.500 mg/kg) disrupted habituation and produced heightened sensitivity to dishabituation stimuli.The results were accommodated by a modified dualprocess theory of habituation; single process views of habituation were inadequate. The significance of these results to drug facilitation was discussed in terms of optimal arousal and the mediation of pro-and retroactive influences on learning. The characterization of processes underlying memory storage seems amenable to further clarification using CNS stimulants known to operate on such processes.Many central nervous system (CNS) stimulants have been useful tools in the investigation of memory storage processes [32]. Appropriately selected doses of these stimulants have allowed the experimental facilitation or disruption of memory storage processes [34]
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