Cycloheximide effects on electroencephalographic and evoked responses in mice

Wilcox, George L.; Andry, Diane K.; Luttges, Marvin W.

doi:10.1016/s0091-6773(74)91056-6

Cited by 10 publications

(3 citation statements)

References 16 publications

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“…It is quite unlikely that these disturbances in electrical activity can account for amnesia following protein synthesis inhibition for several reasons. First, CYC given approximately 2 hr before object-discrimination training, so that inhibition of protein synthesis was declining at the time of training, did not produce memory impairment even though according to Wilcox et al (1974) EEG disturbances should have been present during and after training. Similar results have been obtained with AXM (Barondes & Cohen, 1967b) and with ANI (Davis et al, 1980).…”

Section: Abnormal Cerebral Electrical Activitymentioning

confidence: 99%

“…The gross effects of PURO on electrical activity and on seizure threshold cannot account for the amnestic effects of the PSIs, because the glutarimide derivatives-CYC and AXMdo not produce these effects (Cohen & Barondes, 1967;Cohen et al, 1966). More recently, it was reported that CYC does produce measurable alterations in mouse cerebral electrical activity and evoked responses (Wilcox, Andry, & Luttges, 1974). Although these effects of CYC differed from those of PURO and did not constitute gross aberrations in the BEG* there were nevertheless statistically significant abnormalities in the EEG power spectra for at least 24 hr after injection (frequency range examined was 2 to 11 Hz).…”

Section: Abnormal Cerebral Electrical Activitymentioning

confidence: 99%

See 1 more Smart Citation

Protein synthesis and memory: A review.

Davis¹,

Squire²

1984

Psychological Bulletin

1,370

893

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The hypothesis that memory depends in part on de novo brain protein synthesis has stimulated hundreds of experimental studies during the past 20 years involving drugs that reversibly inhibit brain protein synthesis. This article reviews those studies. It summarizes the basic findings, considers what stage of memory storage or retrieval is disrupted by the drugs, and reviews the side effects that these drugs have, including their effects on brain catecholamine metabolism. It is concluded that the available data make a compelling and internally consistent case for the hypothesis that protein synthesis, during or shortly after training, is an essential step in the formation of long-term memory.

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Section: Abnormal Cerebral Electrical Activitymentioning

confidence: 99%

Section: Abnormal Cerebral Electrical Activitymentioning

confidence: 99%

Protein synthesis and memory: A review.

Davis¹,

Squire²

1984

Psychological Bulletin

1,370

893

View full text Add to dashboard Cite

show abstract

“…Transcommissural evoked responses were present and appeared to be normal. Amplitude and wave-shape were not evaluated statistically so it is possible that subtle changes may have been missed (see Wilcox et al, 1974). Nevertheless, it seemed clear that there were no gross alterations in the usual indices of cerebral electrical activity.…”

Section: Effects Of Cycloheximide On Behavior and Eegmentioning

confidence: 99%

Secondary Epileptogenesis in Frog Forebrain: Effect of Inhibition of Protein Synthesis

Morrell

Tsuru

Hoeppner

et al. 1975

Can. j. neurol. sci.

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SUMMARY:Secondary epileptogenesis was induced in the hippocampal cortex of the paralyzed bullfrog by means of localized, unilateral, intermittent electrical stimulation (kindling). Stimuli were designed to yield a brief but definite after-discharge. In control animals a progressive increase in after-discharge duration occurred at the 1° (stimulated) site and then at the 2° site (contralateral hippocampus). Spontaneous epileptiform potentials (SEP's) occurred between stimuli, eventually independently on both sides.Cycloheximide (50 mg/kg) caused 88-99% reduction in protein synthesis, measured by 14C-leucine incorporation into brain protein. Cycloheximide-treated animals revealed no evidence of progressive prolongation of after-discharge duration when subjected to the kindling procedure (p = 0.1205xl0-7). SEP's were reduced in the cycloheximide-treated animals, and confined to 1° hemisphere (p=0.6xl0-10).Since cycloheximide did not disturb normal electrogenesis or disrupt the after-discharges, this experiment distinguishes processes dependent upon electrical events from those requiring macromolecular synthesis. Protein synthesis seems critical to the emergence of spontaneous and autonomous epileptiform behavior of neural aggregates.

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