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The excitation of lossy mode resonance (LMR) in guided-wave optics is explored. Side-polished fibers underpin the LMR phenomenon with outstanding performance in biosensing applications. Limit of detection of the order of femtomolar has been demonstrated.

We present a novel covalent functionalization of a D-shape fiber biosensor based on Lossy Mode Resonances. IgG/anti-IgG model is applied to prove the regeneration of the union and thus the re-usability of the sensor.