A novel palladium-catalyzed, norbornene-mediated
intermolecular
dehydrogenative annulation approach for the synthesis of 6-fluoroalkyl-phenanthridines
from aryl iodides and fluorinated imidoyl chlorides, which are important
structural motifs for bioactive molecules, is reported. Fluorinated
imidoyl chlorides served as a new type of electrophilic reagent in
the Catellani-type reaction, which, in turn, could be readily prepared
from various anilines and fluorinated carboxylic acids. Control experiments
were carried out to study the mechanism of the reaction. This transformation
is scalable and tolerates a broad range of functional groups.
We reported an efficient palladium-catalyzed domino Heck-silylation of alkene-tethered carbamoyl chlorides with hexamethyldisilane. By using this protocol, a variety of mono- and disilylated oxindoles were obtained in moderate to good...
A series of difurylarylmethanes were prepared in high yields by condensation of 2-methylfuran with aromatic aldehydes in the presence of bromodimethylsufonium bromide (BMDS) at room temperature under solvent-free conditions. All products were characterized by 1 H NMR and 13 C NMR spectra.
The asymmetric unit of the title compound, C9H7N7·2H2O, comprises three formula units. The dihedral angles between the triazole rings and the respective central pyridine rings are 4.87 (16)/1.39 (17), 6.46 (16)/7.61 (16) and 7.00 (16)/3.77 (17)°. The water molecules form O—H⋯O hydrogen bonds between themselves and O—H⋯N hydrogen bonds with the N-atom acceptors of the triazole rings, producing a three-dimensional framework.
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