Our study revealed that systemic administration of BRT also has an IOP reducing effect. MEL has no neuroprotective effect on RGCs; on the other hand, BRT acts as a neuroprotective agent against glaucomatous injury, when applied systemically.
A 29-year-old female patient presented with a painless mass on her upper eyelid medially. She noticed the mass 4 years earlier and it had increased in size over time. She had no diplopia, eyelid swelling, skin lesion overlying the mass, or visual disturbances. On ocular examination, eye movements and funduscopy were normal. The mass was movable and painless with palpation. Magnetic resonance imaging with contrast showed a 12x8x7 mm well-circumscribed cystic lesion with no contrast dye appearance. Surgical removal was performed delicately and no capsular rupture occured. Pathological examination revealed an eccrine hidrocystoma. Our aim is to underline that eccrine hidrocystoma should be included in differential diagnosis of orbital masses.
We retrospectively evaluated the tolerability and efficacy of fractionated total body irradiation (TBI) (1,200 cGy) and melphalan (MEL) (100-110 mg/m(2)) myeloablative conditioning in 48 patients with nonremission AML (n = 14), ALL (n = 10), NHL (n = 18), and other refractory hematologic malignancies (n = 6) who received allogeneic stem cell transplantation (SCT) between 2002 and 2011. Median age was 48 years (22 to 68); 14 out of 26 leukemia patients (54 %) had circulating blasts at transplant, 20 (50 %) evaluable patients had poor-risk cytogenetics, 12 (25 %) had prior SCT, and 10 (21 %) received stem cells from a mismatch donor. All patients received tacrolimus with or without methotrexate for GVHD prophylaxis. At the time of analysis, 13 patients (27 %) were alive and disease free. Engraftment was complete in all patients. The median time to ANC recovery (>500) was 12 days (range, 6-28). The most common grade III and IV toxicities were mucositis and infections. Eighteen patients (43 %) developed grade II-IV acute GVHD, and eight (26 %) had extensive chronic GVHD. Of 44 evaluable patients for response, 28 (64 %) achieved a complete remission (CR), and seven (15 %) had a partial remission after the transplant. With a median follow-up of 30 months (4 to 124 months) for surviving patients, the cumulative incidence of relapse was 45 % at 1 year, and the probability of overall survival (OS) at 5 years was 22.5 %. Multivariate analysis showed that platelet count (<80,000/mL) and lactic dehydrogenase (>500 IU/L) at SCT were associated with relapse. Age less than 53 years and CR after SCT were associated with better OS. Our data suggest that TBI-MEL can result in CR in two thirds, durable remission in one third, and 5-year survival in about one quarter of patients with nonremission hematologic malignancies. Further studies with TBI-MEL in standard risk transplant patients are warranted.
lokomun en önemli risk faktörü göz içi basıncı (GİB) yüksekliğidir. 1 GİB'in doğru olarak ölçümü glokom risk değerlendirmesi ve izleminde çok önemli bir klinik testtir. Günümüzde GİB ölçümü için farklı tonometreler uygulanmakta ise de Goldmann aplanasyon tonometresi (GAT) GİB ölçümünde "altın standart" olarak kabul edilmektedir.2 Fakat GAT ile yapılan GİB ölçümü, başta santral kornea kalınlığı (SKK) olmak üzere; gözyaşı film tabakası, korneal kurvatürü ve oküler rijiditeden etkilenmektedir.3 GAT'ın kalibrasyonunda standart bir SKK (520 µm) kabulTurkiye Klinikleri J Ophthalmol 2017;26(3):193-7 193 Farklı Tonometreler ile Yapılan Göz İçi Basıncı Ölçümlerinin Kornea Kalınlığına Göre Analizi Ö ÖZ ZE ET T A Am ma aç ç: : Icare tonometresi, Goldmann aplanasyon tonometresi (GAT), oküler yanıt analizörü (ORA), Pascal dinamik kontür tonometresi (PDKT), Tono-Pen, Air-puff tonometrelerinin kornea kalınlıklarına göre göz içi basıncı (GİB) ölçüm değerlerindeki farklılıklar incelendi. G Ge er re eç ç v ve e Y Yö ön n--t te em ml le er r: : Sağlıklı 37 hastanın 74 gözü çalışma kapsamına alındı. Olguların santral kornea kalınlıkları ve altı farklı tonometre ile göz içi basınç (GİB) ölçümleri yapıldı. Kornea kalınlığı 550 µm'nin altında (Grup A) ve 550 µm ve üstünde (Grup B) olanlardan elde edilen GİB sonuçları istatistiksel olarak karşılaştırıldı. B Bu ul lg gu ul la ar r: : Grup A'da Icare, Tono-Pen ve Air-puff ölçümleri arasında anlamlı bir fark saptanamaz iken (p>0,05); diğer yandan ORA, GAT, PDKT ölçümleri arasında anlamlı bir fark bulunmuştur (p<0,05). Grup B'de ise Icare ile Tono-Pen, Air-puff, ORA, GAT, PDKT ölçümleri arasında anlamlı bir fark belirlenmiştir (p<0,05). S So on nu uç ç: : Özellikle ince kornealı hastalarda Pascal dinamik kontür tonometresi, Tono-Pen ve Icare tonometreleri daha güvenilir GİB ölçümü sağlamaktadır.A An na ah ht ta ar r K Ke el li im me el le er r: : İntraoküler basınç; tonometri, göz
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