In this study, the effect of nickel (Ni), mercury (Hg) and nickel plus mercury (Ni+ Hg) on fatty acid composition in the muscle tissues of fish Lates calcarifer has been investigated. It was determined from the results of 96 h metal exposure period of fish, depending on Ni, Hg and Ni plus Hg concentration, the amount of saturated fatty, mono unsaturated fatty acid and poly unsaturated fatty acids in fish were decreased when compared with control group (p<0.05). It was also found that Ni, Hg and Ni plus Hg had reduced effects on palmitoleic, linoleic, arachidonic acid, eicosapentaenoic, decosapentaenoic and docosahexaenoic belong to unsaturated fatty acid in muscle tissue. The data demonstrated the necessity for regular monitoring of the hazard quotient for food fish in wild conditions.

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