Synergistic Effect of Nickel and Mercury on Fatty Acid Composition in the Muscle of Fish Lates calcarifer

Senthamils, D.; Chezhian, A.; Suresh, E. R.

doi:10.3923/jfas.2016.77.84

Cited by 13 publications

(5 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The presence of chemical contaminants in the environment and feed in aquaculture areas may cause significant metal accumulation in aquaculture food products ( Tahity et al, 2022 ). Heavy metals are considered to be the most severe source of pollution in the aquatic environment due to their toxicity and absorption ( Senthamils et al, 2015 ). Heavy metal toxicity is determined by a number of parameters, including the dose, route of exposure, as well as age, gender, genetics, and nutritional state of those who have been exposed.…”

Section: Introductionmentioning

confidence: 99%

Effects of cooking methods and co-ingested foods on mercury bioaccessibility in pontic shad (Alosa immaculata)

Milea,

Lazăr,

Simionov

et al. 2023

Current Research in Food Science

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Effects of cooking methods and co-ingested foods on mercury bioaccessibility in pontic shad (Alosa immaculata)

Milea,

Lazăr,

Simionov

et al. 2023

Current Research in Food Science

View full text Add to dashboard Cite

“…At 10,000× the WHO safety limit, the combination of the two metals resulted in haemolysis and caused a synergistic effect. A study on the synergistic effect of Ni and Hg on fatty acid composition in the muscle of fish conducted by Senthamilselvan et al (2016) found that at high concentrations of 0.8, 2.0 and 4.0 mg/L of Hg alone, Ni alone and Hg + Ni combination caused a decrease in fatty acid composition. Hg is a toxic and inhibitory metal in nature whilst Mn is an enhancer of growth at recommended WHO safety limits.…”

Section: Discussionmentioning

confidence: 99%

Whole blood ultrastructural alterations by mercury, nickel and manganese alone and in combination: An ex vivo investigation

et al. 2020

View full text Add to dashboard Cite

The distribution of metals across the environment is increasingly becoming a major concern as they not only pollute the environment but also pose a danger to humans and animals. Human exposure to heavy metals often occurs as a combination of metals the synergistic effects of which can be more toxic than a single metal. The aim of this study was to investigate the effects that the metals mercury (Hg), nickel (Ni) and manganese (Mn) alone and in combination have on erythrocyte morphology and other components of the coagulation system using the haemolysis assay, scanning electron microscopy (SEM), and confocal laser scanning microscopy. Human blood was exposed to the heavy metals ex vivo, and percentage haemolysis was determined. Ultrastructural analysis of erythrocytes, platelets and fibrin networks was performed using SEM. Analysis of phosphatidylserine (PS) flip-flop was determined using confocal laser scanning microscopy. At the highest concentration of 10,000× the World Health Organization safety limit, all the metals caused haemolysis. The results showed that the exposure of erythrocytes to Hg alone and in combination with other metals displayed more haemolysis compared to Ni and Mn alone and in combination. Components of the coagulation system showed ultrastructural changes, including the formation of echinocytes and the activation of platelets with all single metals as well as the combinations. Confocal laser scanning microscopy analysis showed the presence of PS on the outer surface of the echinocytes that were exposed to metals alone and in combination. It can, therefore, be concluded that these heavy metals have a negative impact on erythrocytes and the coagulation system.

show abstract

“…Other metals/metalloids shown to have synergistic and/or antagonistic relationship with Hg include -Cr: e.g., synergistic action with Hg on fish (See: Selvan et al, 2012;Dwivedi et al, 2012); As: e.g., synergistic action in attenuating canonical and noncanonical NLRP3 inflammasome activation (See: Ahn et al, 2018); Pb: combined exposure (synergism) to Pb, inorganic Hg and MeHg showing deviation from additivity for cardiovascular toxicity in rats (See: Dwivedi et al, 2012) and Ni: synergistic effect of Ni and Hg on fatty acid composition in the muscle of fish Lates calcarifer (See: Senthamilselvan et al, 2016).…”

Section: Associations (Synergism/antagonism)mentioning

confidence: 99%

An updated review of the salient geomedical aspects of mercury for enhancement of data quality in simulation modelling and other prognostic applications: Africa case descriptions

Davies

2023

Front. Anal. Sci.

View full text Add to dashboard Cite

Mercury (Hg) pollution is of global concern. Despite the prolificity of research in the past two decades or so, there are still several uncertainties and variabilities in our knowledge of both the element’s exposure dynamics and its health effects. Understanding the intricacies of the element’s emissions-to-impact path, for instance, is rendered intractable by its varied environmental fate and the overarching influence of environmental, geochemical, biological and socioeconomic drivers. In this paper, an updated synopsis of the relevant and more important geomedical characteristics of Hg is considered to constitute part of the provision of high-quality input data needed in Hg simulation modelling studies, and other applications such as the provision of long-term data necessary for evaluating the effectiveness of regulatory measures at various scales. A critical overview is presented on the importance of data quality in parameterisation, and validation of Hg simulation models and other related applications. In this connection, the dearth of modern measurements of Hg abundance in crustal rocks and other Earth materials which needs to be set prior to simulation as well as in modelling source to sink transfers in the Hg cycle, is highlighted. An improved input data quality would also foster the production of model outcomes that are accurate enough for applications in design of better exposure-limiting strategies; and in providing insights on how the course of diagnosis and treatment currently proffered by physicians for Hg-induced maladies, can be revised or expanded. Model results derived from high-quality input datasets also have a high potential for providing forecasting capabilities to inform policy.

show abstract

Synergistic Effect of Nickel and Mercury on Fatty Acid Composition in the Muscle of Fish Lates calcarifer

Cited by 13 publications

References 21 publications

Effects of cooking methods and co-ingested foods on mercury bioaccessibility in pontic shad (Alosa immaculata)

Effects of cooking methods and co-ingested foods on mercury bioaccessibility in pontic shad (Alosa immaculata)

Whole blood ultrastructural alterations by mercury, nickel and manganese alone and in combination: An ex vivo investigation

An updated review of the salient geomedical aspects of mercury for enhancement of data quality in simulation modelling and other prognostic applications: Africa case descriptions

Contact Info

Product

Resources

About