Hospital case notes and chest radiographs of 100 patients with Marfan syndrome were investigated for evidence of pulmonary disease. The criteria for inclusion of details of a given patient in the study were the occurrence of Marfan abnormalities in at least two separate body systems (skeletal, cardiovascular, ocular)

of glyoxylate, or oxalate, in the presence of acetylcoenzyme A. 8. It is suggested that during growth on oxalate, the oxalate, possibly in the form ofoxalyl-coenzyme A, is reduced to glyoxylate, which is taken to be the precursor of glycine and phosphoglycerate. The phosphoglycerate formed then enters established routes of biosynthesis. We wish to thank Professor Sir Hans A. Krebs, F.R.S., for his interest and encouragement and Mrs M. Jenkins for her skilled technical assistance. This work was supported by the Rockefeller Foundation and by the Office of Scientific Research of the Air Research and Development Command of the United States Air Force, through its European Office, under contract no. AF. 61(052)-180, and was done while one of us (D. B. K.) held an Overseas Scholarship of the Commonwealth Scientific and Industrial Research Organization (Australia).

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