The distribution of group-specific antigen of murine leukemia viruses (MuL V-gs) was studied in mice of low-leukemic strains: CS7BL/6, CS7BLIIOSn, BALBIc and others. A rabbit monospecific anti-MuL V-gs serum was used for the antigen detection. The analyses were carried out by an indirect immunoradioautography technique which permitted the detection of trace amounts of the antigen. MuLV-gs was found in the spleen of mice of all strains studied. It was present in mouse embryos as well as in adult animals.
Presence of alpha-fetoprotein (AFP) in a patient's blood is a diagnostic characteristic of hepatocellular cancer and teratoblastomas. The AFP-test is highly specific for these forms of cancer and gives only a very small percentage of false-positive reactions, which occur mainly in hepatitis and metastatic liver cancer (for review see: Abelev, 1971 ;Tatarinov, 1970). The standard test for AFP is usually made with the agarprecipitation technique which has a sensitivity equal to 3 or 5 pg/ml AFP and, in any case, not exceeding 1 ,ug/ml. A more sensitive technique, i.e. immunoradioautography (IR), enabled us to greatly increase the percentage of hepatomas and teratoblastomas revealed serologically (up to 87% and 90%, respectively), but simultaneously, a proportion of the patients with liver diseases became positive for AFP as well. The proportion of positive reactions rose to 13% in viral hepatitis and to 15% in cases of metastases in the liver Abelev, 1971). To explain these clinical findings it was suggested that small amounts of AFP were produced by regenerating liver, a fact which was demonstrated in experiments with mice and rats (Abelev et al., 1963;Bakirov, 1968;Perova et al., 1971).
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