Computer-aided tissue engineering (CATE) enables many novel approaches in modelling, design and fabrication of complex tissue substitutes with enhanced functionality and improved cell-matrix interactions. Central to CATE is its bio-tissue informatics model that represents tissue biological, biomechanical and biochemical information that serves as a central repository to interface design, simulation and tissue fabrication. The present paper discusses the application of a CATE approach to the biomimetic design of bone tissue scaffold. A general CATE-based process for biomimetic modelling, anatomic reconstruction, computer-assisted-design of tissue scaffold, quantitative-computed-tomography characterization, finite element analysis and freeform extruding deposition for fabrication of scaffold is presented.

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This work makes a three-fold contribution for a unit-cell based methodology for designing tissue scaffolds. We present a study on unit-cell informatics; we also propose computational methods to characterize unit-cells, and finally we develop criteria for connectivity between unit-cells. We will define a set of unit-cell parameters relevant for the geometrical, structural, mechanical, transport, and biological properties in tissue engineering applications. We will also present computation and engineering based approaches to evaluate unit-cell properties. We will also develop a combinatorial framework to study the unit-cell topological connectivity and scaffold properties. Using this information, we will be able to design an interconnected 3D porous scaffold to meet application requirements.

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