The correspondence between seismic velocity anomalies in the crust and mantle and the differential incision of the continental-scale Colorado River system suggests that signifi cant mantle-to-surface interactions can take place deep within continental interiors. The Colorado Rocky Mountain region exhibits low-seismic-velocity crust and mantle associated with atypically high (and rough) topography, steep normalized river segments, and areas of greatest differential river incision. Thermochronologic and geologic data show that regional exhumation accelerated starting ca. 6-10 Ma, especially in regions underlain by low-velocity mantle. Integration and synthesis of diverse geologic and geophysical data sets support the provocative hypothesis that Neogene mantle convection has driven long-wavelength surface deformation and tilting over the past 10 Ma. Attendant surface uplift on the order of 500-1000 m may account for ~25%-50% of the current elevation of the region, with the rest achieved during Laramide and mid-Tertiary uplift episodes. This hypothesis highlights the importance of continued multidisciplinary tests of the nature and magnitude of surface responses to mantle dynamics in intraplate settings.

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Advances in computer-aided technology and its application with biology, engineering and information science to tissue engineering have evolved a new field of computer-aided tissue engineering (CATE). This emerging field encompasses computer-aided design (CAD), image processing, manufacturing and solid free-form fabrication (SFF) for modelling, designing, simulation and manufacturing of biological tissue and organ substitutes. The present Review describes some salient advances in this field, particularly in computer-aided tissue modeling, computer-aided tissue informatics and computer-aided tissue scaffold design and fabrication. Methodologies of development of CATE modelling from high-resolution non-invasive imaging and image-based three-dimensional reconstruction, and various reconstructive techniques for CAD-based tissue modelling generation will be described. The latest development in SFF to tissue engineering and a framework of bio-blueprint modelling for three-dimensional cell and organ printing will also be introduced.

Successes in scaffold guided tissue engineering require scaffolds to have speci c macroscopic geometries and internal architectures to provide the needed biological and biophysical functions. Freeform fabrication provides an effective process tool to manufacture many advanced scaffolds with designed properties. This paper reports our recent study on using a novel precision extruding deposition (PED) process technique to directly fabricate cellular poly-ecaprolactone (PCL) scaffolds. Scaffolds with a controlled pore size of 250 m m and designed structural orientations were fabricated.

Computer-aided tissue engineering (CATE) enables many novel approaches in modelling, design and fabrication of complex tissue substitutes with enhanced functionality and improved cell-matrix interactions. Central to CATE is its bio-tissue informatics model that represents tissue biological, biomechanical and biochemical information that serves as a central repository to interface design, simulation and tissue fabrication. The present paper discusses the application of a CATE approach to the biomimetic design of bone tissue scaffold. A general CATE-based process for biomimetic modelling, anatomic reconstruction, computer-assisted-design of tissue scaffold, quantitative-computed-tomography characterization, finite element analysis and freeform extruding deposition for fabrication of scaffold is presented.

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New cosmogenic burial and published dates of Colorado and Green river terraces are used to infer variable incision rates along the rivers in the past 10 Ma. A knickpoint at Lees Ferry separates the lower and upper Colorado River basins. We obtained an isochron cosmogenic burial date of 1.5 ± 0.13 Ma on a 190-m-high strath terrace near Bullfrog Basin, Utah (upstream of Lees Ferry). This age yields an average incision rate of 126 +12/-10 m/Ma above the knickpoint and is three times older than a cosmogenic surface age on the same terrace, suggesting that surface dates inferred by exposure dating may be minimum ages. Incision rates below LeesFerry are faster, ~170 m/Ma-230 m/Ma, suggesting upstream knickpoint migration over the past several million years. A terrace at Hite (above Lees Ferry) yields an isochron burial age of 0.29 ± 0.17 Ma, and a rate of ~300-900 m/Ma, corroborating incision acceleration in Glen Canyon. Within the upper basin, isochron cosmogenic burial dates of 1.48 ± 0.12 Ma on a 60 m terrace near the Green River in Desolation Canyon, Utah, and 1.2 ± 0.3 Ma on a 120 m terrace upstream of Flaming Gorge, Wyoming, give incision rates of 41± 3 m/Ma and 100 +33/-20 m/Ma, respectively. In contrast, incision rates along the upper Colorado River are 150 m/Ma over 0.64 and 10 Ma time frames. Higher incision rates, gradient, and discharge along the upper Colorado River relative to the Green River are consistent with differential rock uplift of the Colorado Rockies relative to the Colorado Plateau.

The Black Canyon of the Gunnison and Unaweep Canyon in western Colorado have long been viewed as classic examples of post-Laramide Plio-Pleistocene uplift, which in the case of Unaweep, is thought to have forced the Gunnison River to abandon the canyon. Ongoing fi eld studies of the incision histories of these canyons and their surrounding regions, however, suggest that post-Laramide rock uplift has been regional, rather than local in nature. River incision rates calculated using ca. 10 Ma basaltic lava fl ows as a late Miocene datum suggest that long-term incision rates range from 61 to 142 m/m.y. with rates decreasing eastward towards the central Rocky Mountains. Incision rates calculated using the ca. 640 ka Lava Creek B ash range from 95 to 162 m/m.y., decrease eastward towards the mountains, and are broadly similar in magnitude to the longer-term incision rates. Locally, incision rates are as high as 500-600 m/m.y. along the lower reaches of the Black Canyon of the Gunnison, and these anomalously high values refl ect transient knickpoint migration upvalley. Knickpoint migration was controlled, in part, by downvalley base-level changes related to stream piracy. For example, abandonment of Unaweep Canyon by the Gunnison River could have led to rapid incision through erodible Mancos Shale as the Gunnison River joined the Colorado River on its course around the northern end of the Uncompahgre Plateau. Geophysical data show that abandonment of Unaweep Canyon was not caused by differential uplift of the crest of Unaweep Canyon relative to the surrounding basins. Instead, the ancestral (Plio-Pleistocene?) Gunnison River fl owed through Cactus Park, a major paleovalley that feeds into Unaweep Canyon, and continued downvalley to its juncture with the Dolores River near present-day Gateway, Colorado. The average gradient of the ancestral Gunnison River through the canyon prior to abandonment was ~7.5-7.6 m/km. Lithological and mineralogical considerations suggest that the Colorado River also fl owed through and helped to carve Unaweep Canyon, although the Colorado River probably exited Unaweep Canyon prior to abandonment by the Gunnison River. The ancestral Gunnison River remained in its course and incised through bedrock for a long enough period of time to produce terrace remnants in the Cactus Park region that range in elevation from 2000 to 1880 m. Abandonment of the canyon by the Gunnison River was followed by formation of a natural dam that probably led to deposition upvalley of ~50 m of lacustrine sediments in Cactus Park. Recent mapping in the lower reaches of Unaweep Canyon indicate that a landslide could have led to damming of Unaweep Canyon, perhaps while it was occupied by underfi t streams.