Bio-CAD modeling and its applications in computer-aided tissue engineering

Sun, Wei; Starly, Binil; Nam, Jae Do; Darling, Andrew

doi:10.1016/j.cad.2005.02.002

Cited by 333 publications

(212 citation statements)

References 34 publications

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“…The STL files were further edited and converted to C1 NURBS surfaces, and then to CAD solid models (.igs extension B-rep surfaces) using Raindrop Geomagic Studio® and/or Rapidform® software (Fig. 10) (Sun, 2005). The solid models can be edited, meshed and joined using I-DEAS® 10 software and then exported to ANSYS® 10 for finite element analyses.…”

Section: Bone Morphometry 3d Rendering and Solid Modelling For Feamentioning

confidence: 99%

Orthodontic mechanotransduction and the role of the P2X7 receptor

Viecilli

Katona

Chen

et al. 2009

American Journal of Orthodontics and Dentofacial Orthopedics

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DEDICATIONTo my parents, who have supported my education. iv ACKNOWLEDGMENTSOne of the most important things I have learned during my PhD is the necessity of the existence of a working network of people that can help you achieve your goals. The more effectively this network functions, the higher the chance you will achieve the goals quickly.I would first like to thank my parents, who have unconditionally supported my decision to abandon a profitable private practice in Orthodontics, and return to humble student conditions while aiming for a full time academic career.I also thank my girlfriend Laura Kruter who has (almost always) been ok with my, some might say, not very sane ideas. Sometimes they do turn out fine, though (like this "PhD" one).I can hardly think of anyone else that could have complemented my work and ideas during this Program as well as Dr. Thomas Katona. While I was passionately conditioned to an idea, he was always rational and careful. While I was sometimes furious with a shortcoming, he was always temperate and humorous. When I ran into his office with some news about a project, he would always listen and almost never seem too busy to see me. While I was working and something went wrong, he would listen and wonder with me about the "whys" and "hows", instead of telling me what to do or express disappointment. He was even subject to some of my home culinary experiments. I was extremely fortunate to find someone that thought about science the same way I did, and that actually helped me with my project instead of just telling me what to do. I felt like we worked as a team, and that helped to increase my motivation during my studies. The third part of this project tested the role of the P2X7 receptor in the dentoalveolar morphology of C57B/6 mice. P2X7R KO (knockout) mice were compared to C57B/6 WT to identify differences in a maxillary molar and bone. Tooth dimensions viii were measured and 3D bone morphometry was conducted. No statistically significant differences were found between the two mouse types. P2X7R does not have a major effect on alveolar bone or tooth morphology.The final part examines the role of the P2X7 receptor in a controlled biomechanical model. Orthodontic mechanotransduction was compared in wild-type (WT) and P2X7R knock-out (KO) mice. Using Finite Element Analysis, mouse mechanics were scaled to produce typical human stress levels. Relationships between the biological responses and the calculated stresses were statistically tested and compared.There were direct relationships between certain stress magnitudes and root resorption and bone formation. Hyalinization and root and bone resorption were different in WT and KO. Orthodontic responses are related to the principal stress patterns in the PDL and the P2X7 receptor plays a significant role in their mechanotransduction.

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Section: Bone Morphometry 3d Rendering and Solid Modelling For Feamentioning

confidence: 99%

Orthodontic mechanotransduction and the role of the P2X7 receptor

Viecilli

Katona

Chen

et al. 2009

American Journal of Orthodontics and Dentofacial Orthopedics

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“…Desktop Robot Based Rapid Prototyping System: An Advanced Extrusion Based Processing of Biopolymers into 3D Tissue Engineering Scaffolds 109 shape and interconnectivity in order to provide the needed structural integrity, strength, transport, and an ideal micro-environment for the growth of cells and tissues in growth (Sun et al, 2005). There is tremendous need to assess how the exact match of mechanical properties of scaffolds with the native organ is crucial for optimal tissue regeneration.…”

Section: Wwwintechopencommentioning

confidence: 99%

Desktop Robot Based Rapid Prototyping System: An Advanced Extrusion Based Processing of Biopolymers into 3D Tissue Engineering Scaffolds

Hoque¹,

Chuan²

2011

Rapid Prototyping Technology - Principles and Functional Requirements

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“…The need of relevant gradients of properties for the promotion of osteochondral repair has led to the development of composite scaffolds using different approaches previously reviewed [27,28]. Typical methods for the manufacture of scaffolds with functional gradients of properties include: the use of embedded (nano ) fibers and textiles within polymeric matrixes [27,28,29], the combination of rigid lattice structures with cell carrying hydrogels [27,28,30], the use of multi layered constructs [31,32] (normally requiring adhesives within layers), and computer aided tissue engineering constructs [33]. Among the most promising approaches, towards stable and effective composite scaffolds, it is important to note the combination of: a) phase separation or leaching processes, normally for obtaining the soft chondral phase, with b) computer aided rapid prototyping technologies based on addi tive manufacturing, usually for manufacturing the rigid bony phase [34].…”

Section: Introductionmentioning

confidence: 99%

Composite scaffolds for osteochondral repair obtained by combination of additive manufacturing, leaching processes and hMSC-CM functionalization

Lantada

Iniesta

García–Ruiz

2016

Materials Science and Engineering: C

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A b s t r a c tArticular repair is a relevant and challenging area for the emerging fields of tissue engineering and biofabrication. The need of significant gradients of properties, for the promotion of osteochondral repair, has led to the develop ment of several families of composite biomaterials and scaffolds, using different effective approaches, although a perfect solution has not yet been found. In this study we present the design, modeling, rapid manufacturing and in vitro testing of a composite scaffold aimed at osteochondral repair. The presented composite scaffold stands out for having a functional gradient of density and stiffness in the bony phase, obtained in titanium by means of computer aided design combined with additive manufacture using selective laser sintering. The chondral phase is obtained by sugar leaching, using a PDMS matrix and sugar as porogen, and is joined to the bony phase during the polymerization of PDMS, therefore avoiding the use of supporting adhesives or additional intermediate layers. The mechanical performance of the construct is biomimetic and the stiffness values of the bony and chondral phases can be tuned to the desired applications, by means of controlled modifications of different parameters. A human mesenchymal stem cell (h MSC) conditioned medium (CM) is used for improving scaffold response. Cell culture results provide relevant information regarding the viability of the composite scaffolds used.

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Bio-CAD modeling and its applications in computer-aided tissue engineering

Cited by 333 publications

References 34 publications

Orthodontic mechanotransduction and the role of the P2X7 receptor

Orthodontic mechanotransduction and the role of the P2X7 receptor

Desktop Robot Based Rapid Prototyping System: An Advanced Extrusion Based Processing of Biopolymers into 3D Tissue Engineering Scaffolds

Composite scaffolds for osteochondral repair obtained by combination of additive manufacturing, leaching processes and hMSC-CM functionalization

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