Computer-aided bone scaffold design: a biomimetic approach

Mechanical evaluation of porous titanium (Ti6Al4V) structures with electron beam melting (EBM)

“…In addition, the effective stiffness of the implant must be comparable to that of healthy surrounding bone tissue to reduce the stress shielding effects, making way for the increased longevity of implants. To reduce the weight and effective stiffness of the titanium implants, the implant structure must be made porous (Parthasarathy et al, 2008(Parthasarathy et al, , 2009Starly et al, 2003;Sun et al, 2005) This necessitates exploration of advanced manufacturing technologies since conventional manufacturing processes fail to produce the desired porosity in the structure. Advanced manufacturing processes based on layered manufacturing principles do provide an alternative for the fabrication of patient specific porous implants.…”

Heterogeneous porous scaffold generation in trivariate B-spline solid with triply periodic minimal surface in the parametric domain

“…First, because the method proposed in [9] generates a porous scaffold by mapping a regular TPMS unit to each hexahedron of a hexahedral mesh model, it has the following shortcomings: (1) Continuity cannot be ensured between two adjacent TPMS units in the porous scaffold. (2) The threshold values C of all TPMS units are the same. (3) The geometric quality of the porous scaffold is greatly influenced by the mesh quality of the hexahedral mesh model.…”

“…In the field of tissue engineering, which aims to repair damaged tissues and organs, porous scaffolds play a critical role in the formation of new functional tissues for medical purposes, i.e., they provide an optimum biological microenvironment for cell attachment, migration, nutrient delivery and product expression [1]. To facilitate cell growth and diffusion of both cells and nutrients throughout the whole structure, high porosity, adequate pore size and connectivity are key requirements in the design of porous scaffolds [2]. Therefore, it is important to be able to control the pore size and porosity when designing heterogenous tissue scaffolds.…”

“…Statistical data of the heterogenous porous scaffold generation method developed in this paper. Run time (in second) for TDF construction, generation of volume TPMS in parametric domain and generation of heterogenous porous scaffold 2. Storage space (in megabyte) of heterogenous porous scaffolds using the traditional STL file format and the TDF file format developed in this paper.…”

Structural Design and Optimization of Interior Scaffolds in Artificial Bone

“…Among these research, spatial arrangement in the bone scaffolds is the most important factor in effecting the bone transform efficiency. Many hypothesis are put forward in these viewpoint, general consider that scaffolds should be designed to match healthy tissue stiffness and strength while maintaining an interconnected pore network for cell migration and nutrient transport [2]. Brekke and Toth pointed out the minimum mechanical strength value of the bone scaffolds, which needs to have the machine capability the under limiting value; R. C. Thomson et al demonstrated the lowest mechanical strength of the bone scaffolds needs to reach about 50~100 Mpa [3].…”