Image-based biomimetic modeling and its application in computer-aided tissue engineering

Darling, Andrew; Starly, Binil; Gomez, Connie; Fang, Z.; Sun, Wei

doi:10.1117/12.479836

Cited by 9 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This requirement can be achieved by controlling the porosity of the structure, by providing appropriate interconnectivity inside the structure, and by selecting appropriate biocompatible materials; (2) mechanical requirement – the designed scaffold must provide structural support at the site of replacement while the tissue regenerates to occupy the space defined by the scaffold structure. Scaffold structures need to be defined to possess the required mechanical stiffness and strength of the replaced structure; and (3) anatomical requirement – it must be of an appropriate geometric size that fits in at the site of replacement [46,47].…”

Section: Computer‐aided Tissue Scaffold Design and Manufacturingmentioning

confidence: 99%

“…A CATE‐based approach for biomimetic modelling and design of load‐bearing tissue scaffolds and replacement has been introduced [46–48]. This approach starts with the acquisition of non‐invasive image and the image processing of appropriate tissue region of interest, followed by a 3D reconstruction of anatomical structure using enabling image‐reconstructive and reverse‐engineering techniques, CAD of scaffold unit cells to represent various tissue anatomical and morphological features, characterization of the structural heterogeneity and mechanical properties for both tissue and designed unit cell through either analytical, numerical or quantitative CT methods in order to select candidate unit cells for final scaffold, and a final design of scaffold with specified internal architecture and anatomic compatible external geometry.…”

Section: Computer‐aided Tissue Scaffold Design and Manufacturingmentioning

confidence: 99%

See 1 more Smart Citation

Computer‐aided tissue engineering: overview, scope and challenges

Sun

Darling

Starly

et al. 2004

Biotech and App Biochem

Self Cite

309

164

View full text Add to dashboard Cite

Advances in computer-aided technology and its application with biology, engineering and information science to tissue engineering have evolved a new field of computer-aided tissue engineering (CATE). This emerging field encompasses computer-aided design (CAD), image processing, manufacturing and solid free-form fabrication (SFF) for modelling, designing, simulation and manufacturing of biological tissue and organ substitutes. The present Review describes some salient advances in this field, particularly in computer-aided tissue modeling, computer-aided tissue informatics and computer-aided tissue scaffold design and fabrication. Methodologies of development of CATE modelling from high-resolution non-invasive imaging and image-based three-dimensional reconstruction, and various reconstructive techniques for CAD-based tissue modelling generation will be described. The latest development in SFF to tissue engineering and a framework of bio-blueprint modelling for three-dimensional cell and organ printing will also be introduced.

show abstract

Section: Computer‐aided Tissue Scaffold Design and Manufacturingmentioning

confidence: 99%

Section: Computer‐aided Tissue Scaffold Design and Manufacturingmentioning

confidence: 99%

Computer‐aided tissue engineering: overview, scope and challenges

Sun

Darling

Starly

et al. 2004

Biotech and App Biochem

Self Cite

309

164

View full text Add to dashboard Cite

show abstract

“…A computer-aided tissue engineering (CATE) approach [6,26,27] for modeling, design and fabrication of tissue scaffolds has been utilized in this study. The CATE approach begins with the acquisition of noninvasive image and the image processing of appropriate tissue region of interest, followed by a 3D reconstruction of anatomical structure using enabling imaging reconstructive and reverse engineering techniques (MIMICS [28] and Geomagic [29]).…”

Section: Design and Fabrication Of Tissue Scaffoldmentioning

confidence: 99%

Computer-aided characterization for effective mechanical properties of porous tissue scaffolds

Fang

Starly

Sun

2005

Computer-Aided Design

122

View full text Add to dashboard Cite

Performance of various functions of the tissue structure depends on porous scaffold microstructures with specific porosity characteristics that influence the behavior of the incorporated or ingrown cells. Understanding the mechanical properties of porous tissue scaffold is important for its biological and biomechanical tissue engineering application. This paper presents a computer aided characterization approach to evaluate the effective mechanical properties of porous tissue scaffold. An outline of a computer-aided tissue engineering approach for design and fabrication of porous tissue scaffold, procedure of computer-aided characterization and its interface with design model, development of a computational algorithm for finite element implementation and numerical solution of asymptotic homogenization theory is presented. Application of the algorithm to characterize the effective mechanical properties of porous poly-1-caprolactone scaffold manufactured by precision extruding freeform deposition will also be presented, along with a parametric study of the process and design parameter to the structural properties of tissue scaffold.

show abstract

Computer-Aided Process Planning for the Layered Fabrication of Porous Scaffold Matrices

Starly

2009

Printed Biomaterials

View full text Add to dashboard Cite

Image-based biomimetic modeling and its application in computer-aided tissue engineering

Cited by 9 publications

References 0 publications

Computer‐aided tissue engineering: overview, scope and challenges

Computer‐aided tissue engineering: overview, scope and challenges

Computer-aided characterization for effective mechanical properties of porous tissue scaffolds

Computer-Aided Process Planning for the Layered Fabrication of Porous Scaffold Matrices

Contact Info

Product

Resources

About