52% Yes, a signiicant crisis 3% No, there is no crisis 7% Don't know 38% Yes, a slight crisis 38% Yes, a slight crisis 1,576 RESEARCHERS SURVEYED M ore than 70% of researchers have tried and failed to reproduce another scientist's experiments, and more than half have failed to reproduce their own experiments. Those are some of the telling figures that emerged from Nature's survey of 1,576 researchers who took a brief online questionnaire on reproducibility in research. The data reveal sometimes-contradictory attitudes towards reproduc-ibility. Although 52% of those surveyed agree that there is a significant 'crisis' of reproducibility, less than 31% think that failure to reproduce published results means that the result is probably wrong, and most say that they still trust the published literature. Data on how much of the scientific literature is reproducible are rare and generally bleak. The best-known analyses, from psychology 1 and cancer biology 2 , found rates of around 40% and 10%, respectively. Our survey respondents were more optimistic: 73% said that they think that at least half of the papers in their field can be trusted, with physicists and chemists generally showing the most confidence. The results capture a confusing snapshot of attitudes around these issues, says Arturo Casadevall, a microbiologist at the Johns Hopkins Bloomberg School of Public Health in Baltimore, Maryland. "At the current time there is no consensus on what reproducibility is or should be. " But just recognizing that is a step forward, he says. "The next step may be identifying what is the problem and to get a consensus. "

Several independent lines of research bear on the question of why individuals avoid decisions by postponing them, failing to act, or accepting the status quo. This review relates findings across several different disciplines and uncovers 4 decision avoidance effects that offer insight into this common but troubling behavior: choice deferral, status quo bias, omission bias, and inaction inertia. These findings are related by common antecedents and consequences in a rational-emotional model of the factors that predispose humans to do nothing. Prominent components of the model include cost-benefit calculations, anticipated regret, and selection difficulty. Other factors affecting decision avoidance through these key components, such as anticipatory negative emotions, decision strategies, counterfactual thinking, and preference uncertainty, are also discussed.

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[1] In the last 25 years of the 20th century most major land regions experienced a summer warming trend, but the central U.S. cooled by 0.2 -0.8 K. In contrast most climate projections using GCMs show warming for all continental interiors including North America. We examined this discrepancy by using a regional climate model and found a circulation-precipitation coupling under enhanced greenhouse gas concentrations that occurs on scales too small for current GCMs to resolve well. Results show a local minimum of warming in the central U.S. (a ''warming hole'') associated with changes in low-level circulations that lead to replenishment of seasonally depleted soil moisture, thereby increasing late-summer evapotranspiration and suppressing daytime maximum temperatures. These regional-scale feedback processes may partly explain the observed late 20th century temperature trend in the central U.S. and potentially could reduce the magnitude of future greenhouse warming in the region.

Large, long-lived convective systems over the United States in 1992 and 1993 have been classified according to physical characteristics observed in satellite imagery as quasi-circular [mesoscale convective complex (MCC)] or elongated [persistent elongated convective system (PECS)] and cataloged. The catalog includes the time of initiation, maximum extent, termination, duration, area of the Ϫ52ЊC cloud shield at the time of maximum extent, significant weather associated with each occurrence, and tracks of the Ϫ52ЊC cloud-shield centroid. Both MCC and PECS favored nocturnal development and on average lasted about 12 h. In both 1992 and 1993, PECS produced Ϫ52ЊC cloud-shield areas of greater extent and occurred more frequently compared with MCCs. The mean position of initiation for PECS in 1992 and 1993 followed a seasonal shift similar to the climatological seasonal shift for MCC occurrences but was displaced eastward of the mean position of MCC initiation in 1992 and 1993. The spatial distribution of MCC and PECS occurrences contain a period of persistent development near 40ЊN in July 1992 and July 1993 that contributed to the extreme wetness experienced in the Midwest during these two months. Both MCC and PECS initiated in environments characterized by deep, synoptic-scale ascent associated with continental-scale baroclinic waves. PECS occurrences initiated more often as vigorous waves exited the intermountain region, whereas MCCs initiated more often within a high-amplitude wave with a trough positioned over the northwestern United States and a ridge positioned over the Great Plains. The low-level jet transported moisture into the region of initiation for both MCC and PECS occurrences. The areal extent of convective initiation was limited by the orientation of low-level features for MCC occurrences.

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Abstract. The first simulation experiment and output archives of the Project to Intercompare Regional Climate Simulations (PIRCS) is described. Initial results from simulations of the summer 1988 drought over the central United States indicate that limited-area models forced by large-scale information at the lateral boundaries reproduce bulk temporal and spatial characteristics of meteorological fields. In particular, the 500 hPa height field time average and temporal variability are generally well simulated by all participating models. Model simulations of precipitation episodes vary depending on the scale of the dynamical forcing. Organized synoptic-scale precipitation systems are simulated deterministically in that precipitation occurs at close to the same time and location as observed (although amounts may vary from observations). Episodes of mesoscale and convective precipitation are represented in a more stochastic sense, with less precise agreement in temporal and spatial patterns. Simulated surface energy fluxes show broad similarity with the First International Satellite Land Surface Climatology Project (ISLSCP) Field Experiment (FIFE) observations in their temporal evolution and time average diurnal cycle. Intermodel differences in midday Bowen ratio tend to be closely associated with precipitation differences. Differences in daily maximum temperatures also are linked to Bowen ratio differences, indicating strong local, surface influence on this field. Although some models have bias with respect to FIFE observations, all tend to reproduce the synoptic variability of observed daily maximum and minimum temperatures. Results also reveal the advantage of an intercomparison in exposing common tendencies of models despite their differences in convective and surface parameterizations and different methods of assimilating lateral boundary conditions.

Chemical and nutrient signaling are fundamental for all cellular processes, including interactions between the mammalian host and the microbiota, which have a significant impact on health and disease. Ethanolamine is an essential component of cell membranes and has profound signaling activity within mammalian cells by modulating inflammatory responses and intestinal physiology. Here, we describe a virulence-regulating pathway in which the foodborne pathogen Salmonella enterica serovar Typhimurium (S. Typhimurium) exploits ethanolamine signaling to recognize and adapt to distinct niches within the host. The bacterial transcription factor EutR promotes ethanolamine metabolism in the intestine, which enables S. Typhimurium to establish infection. Subsequently, EutR directly activates expression of the Salmonella pathogenicity island 2 in the intramacrophage environment, and thus augments intramacrophage survival. Moreover, EutR is critical for robust dissemination during mammalian infection. Our findings reveal that S. Typhimurium co-opts ethanolamine as a signal to coordinate metabolism and then virulence. Because the ability to sense ethanolamine is a conserved trait among pathogenic and commensal bacteria, our work indicates that ethanolamine signaling may be a key step in the localized adaptation of bacteria within their mammalian hosts.