Placental Extract (PE) has been used as a folk remedy in Asian countries. Human PE is clinically used for the treatment of skin wrinkles because it promotes skin regeneration. In this study, we found that Porcine PE (PPE) promoted collagen production in Normal Human Dermal Fibroblasts (NHDFs). Treatment of NHDFs with PPE at concentrations of 12.5-100 μg/mL enhanced their proliferation and secretion of procollagen C peptide. We also found that expression of intracellular Matrix Metalloproteinase-9 (MMP-9) in PPE-treated NHDFs was decreased in a dose-dependent manner. These results indicate that PPE might affect facial wrinkling partly by enhancing fibroblast proliferation and collagen secretion while inhibiting MMP-9 expression in NHDFs.
PPE is useful as an oral supplement for shoulder stiffness in climacteric women without HT or in postmenopausal women with HT-resistant, long-term shoulder stiffness.
We examined the influence of hot water extract of coix seed (Coix lacryma-jobi L. var. ma-yuen Stapf) with husks on facial skin. Ten females (28-58 years old) took hot water extract of coix seed with husks 1 g/day for 8 weeks, and various skin parameters were measured. The results showed that the total amount of subsurface reflection of blue light, which is an index of skin translucency, increased significantly after 8 weeks of intake (p = 0.011). In addition, skin texture improved significantly after 4 and 8 weeks of intake (p = 0.007, p = 0.042). Additionally, the condition of tape-stripped stratum corneum also indicated significant improvement after 4 and 8 weeks intake (p = 0.0002, p = 0.020). These results suggested that the hot water extract of coix seed with husks exhibited effects even at 1 g/day, which is less than in previous reports.
Objective: Placental extracts (PEs) have been used for years as a folk r e m e d y i n A s i a n c o u n t r i e s . P E s mediates alleviation of menopausal s y m p t o m s , w o u n d h e a l i n g a n d liver regeneration. In this study, we evaluated the effect of porcine placental extract (PPE) on monocyte differentiation into dendritic cells (DCs) and cytokine production by monocytes following stimulation with PPE. Methods: Human myelomonocytic cell line, THP-1 were treated with PPE or human placental extract (HPE) in the presence or absence of lipopolysaccharide (LPS) and interferon (IFN)-γ , then the secretion of tumor necrosis factor (TNF)-α and interleukin (IL)-6 was measured by specific ELISA and real-time PCR. We also evaluated the effect of PPE on the expression of the monocytic markers, CD11b, CD80 and HLA-DR, on cultured THP-1 cells as well as DCs derived from peripheral blood mononuclear cells (PBMC) in
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