Efficacy of porcine placental extract on shoulder stiffness in climacteric women

Koike, Koji; Yamamoto, Yasuhiko; Suzuki, Nobutaka; Yamazaki, Rena; Yoshikawa, Chikako; Takano, Fumihide; Sugiura, K.; Inoue, Masakí

doi:10.3109/13697137.2012.720622

Cited by 11 publications

(4 citation statements)

References 19 publications

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“…Placental extracts prepared from human or animal placenta have been used as ingredients in medicines, health foods, and cosmetics. Orally administered placental extracts have been reported to be effective for menopausal disorders [ 15 , 16 ] and their symptoms (e.g., knee pain, shoulder stiffness, and wrinkles below the eyes) [ 17 – 19 ]. Togashi et al reported that an orally administered human placental extract inhibits alcohol-induced hepatic disorder in a mouse model [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

“…Porcine placental extract (PPE) have been developed as an alternative source to human placental extracts due to biosafety concerns [ 17 – 19 , 24 ]. In the current study, we examined PPE-mediated mitigation of oxidative stress, insulin resistance, lipid accumulation, chronic inflammation, and fibrosis in the liver of a diet-induced NASH mouse model.…”

Section: Introductionmentioning

confidence: 99%

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A porcine placental extract prevents steatohepatitis by suppressing activation of macrophages and stellate cells in mice

Nagata

Nagashimada

et al. 2018

Oncotarget

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Nonalcoholic fatty liver disease (NAFLD) is caused by ectopic fat accumulation in the liver. NAFLD is associated with hepatic inflammation and oxidative stress, resulting in nonalcoholic steatohepatitis (NASH) with advanced fibrosis. Placental extracts have been used to treat various chronic diseases due to their antioxidative effect. However, the effects of the extracts on the development of NASH have yet to be elucidated. Here, we demonstrated that supplementation with an oral porcine placental extract (PPE) attenuated lipid accumulation and peroxidation, insulin resistance, inflammatory and stress signaling, and fibrogenesis in the liver of NASH model mice fed a high-cholesterol and high-fat diet. The PPE reduced the number of M1-like liver macrophages, but increased the number of anti-inflammatory M2-like macrophages, resulting in a predominance of M2 over M1 macrophage populations in the liver of NASH mice. Accordingly, the PPE suppressed lipopolysaccharide-induced M1 polarization in isolated murine peritoneal macrophages, whereas it facilitated interleukin 4-induced M2 polarization. Furthermore, the PPE reduced the hepatic stellate cell (HSC) activation associated with the attenuated transforming growth factor-β/Smad3 signaling, both in the liver of NASH mice and in RI-T cells, a HSC line. The PPE may be a potential approach to prevent NASH by limiting lipid peroxidation, promoting M2 macrophage polarization, and attenuating HSC activation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A porcine placental extract prevents steatohepatitis by suppressing activation of macrophages and stellate cells in mice

Nagata

Nagashimada

et al. 2018

Oncotarget

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“…Suzuki et al have proposed the recovery system based on physical exercise 143) and/or utilization of foods based on nutrition science [143][144][145][146][147][148][149][150][151][152][153] . than two diploid copies of the salivary amylase genes (AMY1) 155,156) , The mean diploid copy number of AMY1 within 1KJPN data set comprised by the whole genome sequences of 1,070 healthy Japanese individuals was 8.27 156) , which is significantly higher than the number reported in populations with low consumption of starch …”

Section: Pacific Islandsmentioning

confidence: 99%

Data Intensive Study of Accessibility of Edible Species and Healthcare Across the Globe

Watanabe

Kyo²,

Liu

et al. 2018

JJCAM

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“…Porcine placental extract (PPE) has been recently developed as an oral supplement for use instead of human placenta extract (HPE) ( Yoshikawa et al ., 2014 ). Previous studies have shown that PPE decreased shoulder stiffness, knee pain, and postmenopausal climacteric symptoms ( Koike et al ., 2012 , 2013a , 2013b ). PPE has been shown to protect skin photoaging through decreased matrix metalloproteinase-2 (MMP-2) and MMP-9 mRNA expression in human skin fibroblasts and in vivo ( Yoshikawa et al ., 2013 ; Hong et al ., 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Oral Administration of Glycine and Leucine Dipeptides Improves Skin Hydration and Elasticity in UVB-Irradiated Hairless Mice

Park

Lee

Shin

et al. 2017

Biomolecules & Therapeutics

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Placenta is a special organ that contains many nutrients such as growth factors, minerals, and bioactive peptides. Dipeptides of glycine and leucine are major components of porcine placenta extracts (PPE) that has been used as an alternative of human placenta extracts. In this study, we investigated whether major peptides of PPE, Glycyl-L-Leucine (Gly-Leu), L-Leucyl-Glycine (Leu-Gly), and L-Leucyl-L-Leucine (Leu-Leu), affect skin hydration and elasticity in vitro and in vivo. We found that Gly-Leu and Leu-Gly dipeptides induced the expression of transglutaminase 1 in normal human epidermal keratinocytes (NHEKs) whereas Leu-Leu dipeptides did not. Treatment with Gly-Leu or Leu-Gly significantly increased hyaluronan (HA) synthesis in NHEKs and the upregulation of hyaluronan synthase 2 (HAS2) mRNA level was confirmed. In addition, elastase activity was inhibited in NHEKs treated with Gly-Leu or Leu-Gly dipeptides. Oral administration of Gly-Leu or Leu-Gly dipeptides increased skin hydration and elasticity in UVB-irradiated hairless mice. The significant upregulation of HA in UVB-irradiated hairless mice was observed in response to oral administration of Gly-Leu or Leu-Gly. These results suggest that the major dipeptides of porcine placenta, Gly-Leu and Leu-Gly, are potentially active ingredients for skin moisturization formulations.

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Efficacy of porcine placental extract on shoulder stiffness in climacteric women

Abstract: PPE is useful as an oral supplement for shoulder stiffness in climacteric women without HT or in postmenopausal women with HT-resistant, long-term shoulder stiffness.

Cited by 11 publications

References 19 publications

A porcine placental extract prevents steatohepatitis by suppressing activation of macrophages and stellate cells in mice

A porcine placental extract prevents steatohepatitis by suppressing activation of macrophages and stellate cells in mice

Data Intensive Study of Accessibility of Edible Species and Healthcare Across the Globe

Oral Administration of Glycine and Leucine Dipeptides Improves Skin Hydration and Elasticity in UVB-Irradiated Hairless Mice

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