This study was conducted to investigate the prophylactic effects of carnitine
against contrast-induced nephropathy (CIN) and its relation to oxidant/antioxidant status
in kidney, liver, heart, spleen and lung tissues in a CIN rat model. Twenty-eight adult
male Wistar rats were divided into 4 groups, the control, contrast media (CM), carnitine
and contrast media+carnitine (CM+carnitine) groups. Animals were placed in individual
metabolism cages, and on the 2nd day, rats were deprived of water for 24 hr. On the 3rd
day, contrast media were administered to groups CM and CM+carnitine. L-carnitine was
administered on days 2, 3 and 4. Histopathological changes were evaluated in the right
kidney after euthanization. Superoxide dismutase (SOD) and catalase (CAT) activities and
glutathione (GSH) and malondialdehyde (MDA) levels were measured in renal, liver, heart,
spleen and lung tissues. The SOD activities in the renal (P<0.05),
liver (P<0.001) and spleen (P<0.05) tissues were
increased in the carnitine group. The CAT activities in the spleen tissue were decreased
(P<0.01) only in the CM group. Renal (P<0.05),
liver (P<0.001), spleen (P<0.001) and lung tissue
(P<0.01) GSH levels were found to be higher in the carnitine group.
In renal, liver and lung tissues, the MDA levels increased in the CM group
(P<0.001). The histopathological findings showed that L-carnitine
may have a preventative effect in alleviating the negative effects of CIN. Similar to
this, L-carnitine may play a major role in the stability of the antioxidant status in the
kidney, liver, spleen and lung of the CIN rat model.
The world keeps changing. There are always risks associated with change. To make careful risk assessment it is always needed to re-evaluate the information according to new findings in research. Scientific knowledge is essential in determining the strategy for fish farming. This information should be updated and brought into line with the required conditions of the farm. Therefore, books are one of the indispensable tools for following the results in research and sources to draw information from. The chapters in this book include photos and figures based on scientific literature. Each section is labeled with references for readers to understand, figures, tables and text. Another advantage of the book is the "systematic writing" style of each chapter. There are several existing scientific volumes that focus specially on fish farms. The book consists of twelve distinct chapters. A wide variety of scientists, researchers and other will benefit from this book.
Levels of five heavy metals [copper (Cu), lead (Pb), cadmium (Cd), chromium (Cr) and nickel (Ni)] were evaluated in liver and muscle tissues of fish (Mugil auratus) collected from the Black Sea at Sinop-Icliman, Turkey. Sampling and analysis methods are described. Variations of heavy metal concentrations with seasons are discussed. Cr and Ni concentrations were below the limits of detection (<0.05 and 0.1 ug/g dry weight) in all tissues and seasons. Cu, Pb and Cd were detected within these limits, as mg/kg dry weight, in liver tissue: 0.49-1.30, 0.60-1.21 and 0.15-0.50, and in muscle tissue: 0.30-1.00, 0.57-1.12 and 0.10-0.40, respectively. Cu, Pb and Cd concentrations in these tissues were elevated and the highest heavy metal concentrations were found in the liver. While Cu, Pb and Cd concentrations were highest in fish tissues collected in August 2000, the lowest concentrations of these metals were observed in fish tissues collected in May 2000. Pb had the highest level observed in fish tissues. According to the Turkish Food Codex Regulation's residue limits, the cadmium level determined in fish tissues was high (0.1 mg/g) and the lead level, especially in liver tissue, was high in August (1 mg/ g), while other metals (Cu, Cr and Ni) were within the maximum residue limits.
Subcutaneous administration of meloxicam resulted in long-term presence of drug at high concentration in goat plasma. This unique plasma disposition characteristic may offer an advantage in some clinical cases towards potentially improving the treatment efficacy in goats.
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