The effects of lycopene on DNA damage and oxidative stress on indomethacin-induced gastric ulcer in rats

Boyacıoğlu, Murat; Kum, Cavit; Sekkin, Selim; Yalinkilinc, Hande Sultan; Avcı, Hamdi; Epikmen, Erkmen Tuğrul; Karademir, Umit

doi:10.1016/j.clnu.2015.03.006

Cited by 54 publications

(34 citation statements)

References 24 publications

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“…INDO significantly decreased the GSH levels in the liver, kidney, and brain tissues of the treatment groups compared with the control in the present study. Our results are in line with a reported study, where GSH level was quite low in the INDO group when compared to all other experimental groups .…”

Section: Discussionsupporting

confidence: 93%

“…The TBARS level in the liver, kidney, and brain tissues increased significantly with respect to the control. Similar results were reported by Boyacioglu et al, where MDA level was increased in response to indomethacin administration via oxidative stress in the gastric tissues of rats …”

Section: Discussionsupporting

confidence: 91%

“…The previous study showed that 8‐hydroxy‐2 deoxyguanine level, as a marker of DNA damage, was significantly increased after a single dose of indomethacin (25 mg/kg) . A similar study at the same dose of INDO administration induced significant DNA damage in the lymphocytes . Current results on INDO are further corroborated with our recently published report on NP‐induced MN induction in the male Wistar rats…”

Section: Discussionsupporting

confidence: 84%

“…ROS generation inside the cells causes oxidative damage the membranes (lipid peroxidation [LPO]), proteins, RNA, and DNA molecules, which can lead to the subsequent cell death, further exaggerating the injuries . Oxidative damage results in the formation of superoxide radicals and hydrogen peroxide (H 2 O 2 ), LPO, and protein oxidation, which can directly damage DNA, membrane lipids, cellular proteins, and organelles . Oxidative stress has been implicated as a general mechanism in the toxicity of many NSAIDs .…”

Section: Introductionmentioning

confidence: 99%

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Determination of potential oxidative damage, hepatotoxicity, and cytogenotoxicity in male Wistar rats: Role of indomethacin

Ahmad

Fatima

Hossain

et al. 2018

J Biochem & Molecular Tox

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The present study demonstrated the indomethacin (INDO) induced oxidative stress, hepatotoxicity, and genotoxicity in male Wistar rats. Animals were orally administrated INDO at doses of 0.302 and 0.605 (mg/kg b.w.) for 2 weeks. Reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and lipid peroxidation (LPO) activities/levels were measured in the liver, kidney, and brain tissues. The aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) activities, total bilirubin (TBIL) levels, and histopathological changes were determined in the liver tissues. Micronucleus frequency (micronucleus test) and DNA damage (comet assay) tests were performed in the bone marrow cells and leukocytes, respectively. Results show that INDO treatment decreased the GSH, SOD, and CAT levels/activities and increased the LPO, ALT, AST, ALP, and TBIL activities/levels. INDO induced significant hepatic injury and micronucleus and DNA damage. Thus, the current investigations confirm the oxidative stress, hepatotoxic, and genotoxic properties of INDO in the male Wistar rats.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Determination of potential oxidative damage, hepatotoxicity, and cytogenotoxicity in male Wistar rats: Role of indomethacin

Ahmad

Fatima

Hossain

et al. 2018

J Biochem & Molecular Tox

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“…Also, indomethacin reduced SOD and CAT activities; these enzymes reduce intracellular levels of superoxide radicals. SOD enzyme renovates superoxide anion into H 2 O 2 , which then decomposes into water via CAT and Glutathione Peroxidase (GSHPx) [8]. Indomethacin inhibited the mitochondrial oxidative phosphorylation leading to the release of cytochrome c from mitochondrial inter membranous space into cytosol and to the release of ROS such as superoxide anion and H 2 O 2 .…”

Section: Discussionmentioning

confidence: 99%

Gastroprotective Effect of Vanillin on Indomethacin-Induced Gastric Ulcer in Rats: Protective Pathways and Anti-Secretory Mechanism

Ma¹,

Salahuddin²

2017

Clin Exp Pharmacol

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Indomethacin provokes aggressive ulcerogenic adverse effects. Natural products with fewer side effects are therefore highly requested to attenuate its gastric ulcer effect. Vanillin is a natural compound widely used as flavoring agent which has antioxidant activity. Therefore, the aim of this study was to investigate its gastroprotective effect against indomethacin induced gastric injury. Rats were divided into four groups; first group served as control, group 2: Treated with indomethacin (25 mg/kg, po.), group 3: Pre-treated with ranitidine (reference drug) (50 mg/kg, po., 5 days) before indomethacin and group 4: Pretreated with vanillin (100 mg/kg, po., 5 days). Pre-treatment with vanillin reduced ulcer index, gastric juice volume, free, total acidity and histopathological changes induced by indomethacin. Although it reduced gastric oxidative stress, it elevated enzymatic antioxidant activity and gastric nitric oxide content. Moreover, it reduced gastric NFκB protein expression and activity as well as inhibition in levels of proinflammatory cytokines, Myeloperoxidase (MPO) and caspase 3 activities. It down regulated gene expression of TNF-α, Cytokine-Induced Neutrophil Chemo Attractant (CINC-2α) and caspase-9 while lacking effect on mucosal prostaglandin E2 (PGE2) level. Collectively, vanillin displayed gastroprotective effects in indomethacin induced gastric ulcer by anti-secretory action and cytoprotective effect via antioxidant and anti-inflammatory activities.

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Citrullus lanatus (Thunberg) Matsumura and Nakai

Adetunji,

Michael,

Shariati

et al. 2024

Handbook of Agricultural Biotechnology

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The effects of lycopene on DNA damage and oxidative stress on indomethacin-induced gastric ulcer in rats

Cited by 54 publications

References 24 publications

Determination of potential oxidative damage, hepatotoxicity, and cytogenotoxicity in male Wistar rats: Role of indomethacin

Determination of potential oxidative damage, hepatotoxicity, and cytogenotoxicity in male Wistar rats: Role of indomethacin

Gastroprotective Effect of Vanillin on Indomethacin-Induced Gastric Ulcer in Rats: Protective Pathways and Anti-Secretory Mechanism

Citrullus lanatus (Thunberg) Matsumura and Nakai

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