No abstract

No abstract

No abstract

No abstract

No abstract

Plasma and urinary adrenaline and noradrenaline (A and NA), PBI, he art rate (HR), creatinine c\earance (CC) and arterial pressures (AP) have been measured by the Renzini et al. (1970) method in 9 hyperthyroid, 4 hypothyroid and 13 euthyroid patients. NA plasma concentration was found nonnal or subnormal in hyperthyroids (271.7 ± 140.3 ng/l) in comparison to nonnals (272.5 ± 115 ng/I) and markedly increased in hypothyroids (505 ± 154.6 ng/1). Adrenaline concentration showed the same pattern (51.7 ± 23.9 ng/1) in hyperthyroids, 53.1 ± 6.8 ng/I in euthyroids and 63.1 ± 12.3 ng/I in hypothyroids and so did urinary excretion both during night and day.Changes induced by treatment in two hyper-and one hypothyroid were consistent with this pattern. These results agree with and extend those recently reported for total catecholamines by Stoffer et al. (1973) and by Christensen (1973) for NA.No correlation whatsoever was found between plasma A or NA and HR, AP or CC. On the other hand, both HR ( Figure) and CC correlate weH with PBI concentration suggesting that hemodynamic changes in thyroid disease are mostly due to the thyroid honnone itself. HR min-1 125 100 • o 75 • 50 Figure Rec.: IS Oet.1973 y a 3.+71.3 r = 0.74 pe 0.001 • hypothyroids • euthyroids o hyperthyroids PB I ),9/lOOccInverse relationship between thyroid functional level and catecholamines concentration, may reflect either a cornpensatory adjustment of the neuroadrenergic system, or a metabolie c1earance rate of the amines varying directly with the level of eirculating thyroid hormone.

No abstract

1. Catecholamine plasma concentrations and urinary excretion were measured together with plasma renin activity in ten patients with essential hypertension and in five normal control subjects before and after a frusemide challenge.2. The same procedure was repeated in the same subjects 3-4 days later after pretreatment with oxprenolol.3. Noradrenaline plasma concentrations and urinary excretion increased significantly after frusemide in all cases, returning to normal values at 30 and 60 min. Adrenaline plasma concentrations and urinary excretion were unchanged. 4. Plasma renin activity increased significantly in seven patients with hypertension and normal renin basal values, remaining unchanged in three hypertensive patients with low-renin basal values. 5. Oxprenolol suppressed the response of noradrenaline and plasma renin activity to frusemide in all cases.