Plasma and Urinary Catecholamine Levels and Thyroid Activity in Relation to Cardiovascular Changes in Hyper- and Hypothyroids

Abstract

Plasma and urinary adrenaline and noradrenaline (A and NA), PBI, he art rate (HR), creatinine c\earance (CC) and arterial pressures (AP) have been measured by the Renzini et al. (1970) method in 9 hyperthyroid, 4 hypothyroid and 13 euthyroid patients. NA plasma concentration was found nonnal or subnormal in hyperthyroids (271.7 ± 140.3 ng/l) in comparison to nonnals (272.5 ± 115 ng/I) and markedly increased in hypothyroids (505 ± 154.6 ng/1). Adrenaline concentration showed the same pattern (51.7 ± 23.9 ng/1) in hyperthyroids, 53.1 ± 6.8 ng/I in euthyroids and 63.1 ± 12.3 ng/I in hypothyroids and so did urinary excretion both during night and day.Changes induced by treatment in two hyper-and one hypothyroid were consistent with this pattern. These results agree with and extend those recently reported for total catecholamines by Stoffer et al. (1973) and by Christensen (1973) for NA.No correlation whatsoever was found between plasma A or NA and HR, AP or CC. On the other hand, both HR ( Figure) and CC correlate weH with PBI concentration suggesting that hemodynamic changes in thyroid disease are mostly due to the thyroid honnone itself. HR min-1 125 100 • o 75 • 50 Figure Rec.: IS Oet.1973 y a 3.+71.3 r = 0.74 pe 0.001 • hypothyroids • euthyroids o hyperthyroids PB I ),9/lOOccInverse relationship between thyroid functional level and catecholamines concentration, may reflect either a cornpensatory adjustment of the neuroadrenergic system, or a metabolie c1earance rate of the amines varying directly with the level of eirculating thyroid hormone.

Catecholamine Metabolism in Thyroid Disease. II. Norepinephrine Secretion Rate in Hyperthyroidism and Hypothyroidism

“…There were, however, significantly higher plasma NE concentrations in hypothyroidism (17) in agreement with previous studies (15,16,18). In addition we demonstrated a significant linear correlation between plasma NE and age, such that after correction for the age factor, hypothyroidism is still attended by significantly elevated plasma NE concentrations (17).…”

“…In addition we demonstrated a significant linear correlation between plasma NE and age, such that after correction for the age factor, hypothyroidism is still attended by significantly elevated plasma NE concentrations (17). Hyperthyroidism, on the other hand, is associated with normal plasma NE concentrations (17,18) in contrast to the observations of Christensen (15) and Stoffer et al (16). In this study we have extended our observations on the linear relationship between age and plasma NE (Fig.…”

Metabolic and Body Temperature Changes during Exercise in Hyperthyroid Patients

“…He suggested an inverse relationship between thyroid status and catecholamine release, which reflects a compen satory adjustment of the sympathetic nervous system to the effect of thyroid hormones on the cardiovascular system. This conclusion was further supported by the study of Ghione, Pellegrini, Buzzogioli, Carpi, Valori & Donato (1974). We found no difference between the plasma norad renaline concentration in the hyperthyroid patients and control subjects at rest when sitting.…”

Unstable Angina with Normal Coronary Angiography in Hyperthyroidism: A Case Report

“…One explanation involves the imbalance of oxygen supply and demand, which is caused by sympathetic system activation. Heart rate and contractility are enhanced by increased adrenergic sensitivity due to elevated density and affinity of β receptors [18] with a concomitant decrease in the number and affinity of α receptors [19], although plasma, urinary, and myocardial adrenaline concentrations and turnover levels are normal [20]. In addition, thyroid hormone may have a direct effect on the automaticity [21] and decreased cholinergic inhibition of the sinus node [22].…”