The use of tissue adhesives as an alternative to or replacement for sutures in wound closure has long been an area of interest. One of these tissue adhesives is a cyanoacrylate. In 15 patients, who underwent root resections of the upper incisors on both sides, the incision lines were closed with silk sutures on one side and by n-butyl-2-cyanoacrylate on the other side of the frenum. Clinical comparison was made on the 1st, 2nd, 3rd, 7th, 14th and 21st postoperative days. On the seventh postoperative day following the removal of sutures and the coating, small punch biopsies were obtained from n-butyl-2-cyanoacrylate treated and sutured sides. The tissue specimens were examined under transmission electron microscope. Clinical observations revealed that on the third and seventh postoperative days epithelialization was better on the sides treated with n-butyl-2-cyanoacrylate. On the twenty-first postoperative day it was observed that the scar formation was significantly more marked and there was more local inflammation during the healing period on the sutured side. Electron microscopic observations of both tissue specimens revealed normal ultrastructural morphology.

The synthetic tissue adhesive n-butyl-2-cyanoacrylate (Histoacryl Blue) and silk sutures were compared on the backs of guinea-pigs as the means for closing skin incisions. On the post-operative 3rd, 7th, 14th and 21st days, specimens from each group were obtained and evaluated under light microscopy. Sections were analysed for the degree of inflammation, giant cell reaction, fibroblastic and capillary cell activity and were ranked statistically. The results showed that the silk sutures caused severe inflammatory and giant cell reaction when compared with Histoacryl and the healing process was slower than with n-butyl-2-cyanoacrylate.

The objective of this study has been to characterize sialolith, a calcium phosphate deposit that develops in the human oral cavity, by high-resolution field emission scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS). The morphological and chemical data obtained helped in the determination of their formation mechanism in salivary glands. Sialoliths in the submandibular salivary glands may arise secondary to sialodenitis, but not via a luminal organic nidus. We believe this is the first study that characterizes a sialolith by XPS.

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