Histological and bioadhesion studies on buccal bioadhesive tablets containing a penetration enhancer sodium glycodeoxycholate

Şenel, Sevda; Çapan, Yılmaz; Sargon, Mustafa F.; Giray, C. B.; Hıncal, A. A.

doi:10.1016/s0378-5173(98)00148-3

Cited by 26 publications

(6 citation statements)

References 15 publications

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“…In a study carried out to determine the safety of bile salts as permeation enhancers [8], bioadhesive tablets were prepared with 5 % GDC and tested on healthy volunteers. The bioadhesive tablets were applied to the buccal mucosa and left in place for 4 h to determine the extent of mucosal irritation.…”

Section: Bile Saltsmentioning

confidence: 99%

Chemical Methods for Enhancing Oral Mucosal Delivery

Pather

Kolli²

2015

Advances in Delivery Science and Technology

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Section: Bile Saltsmentioning

confidence: 99%

Chemical Methods for Enhancing Oral Mucosal Delivery

Pather

Kolli²

2015

Advances in Delivery Science and Technology

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“…The increase in permeability of the oral mucosa by the cationic surfactant cetrimide is also well known (11,12). The disadvantage of these effective permeation enhancers is the cause of cell damage (13,14). Use of polymers with permeation-enhancing properties could be an alternative to avoid irritation at the site of administration caused by surfactants (15).…”

Section: Introductionmentioning

confidence: 98%

In Vitro Evaluation of Various Buccal Permeation Enhancing Systems for PACAP (Pituitary Adenylate Cyclase-Activating Polypeptide)

Langoth¹,

Bernkop‐Schnürch

2005

Pharm Res

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“…Many researchers had already reported the permeation enhancing efficiency of bile salts [10][11][12] . Therefore, sodium taurocholate was chosen as a permeation enhancing agent.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2011

IJPSR

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The objective of the paper is to study the effect of a permeation enhancer, sodium taurocholate on permeation of Ondansetron HCl from bioadhesive buccal tablet formulation by performing ex-vivo permeation experiments using porcine buccal mucosa. Optimized formulation has selected based on in-vitro drug release studies of bilayered bioadhesive buccal tablets. To the optimized formulation, 10mM sodium taurocholate was added to increase the permeation of poorly permeable ondansetron HCl. It is well known that natural surfactants like bile salts increase the permeability of drugs by perturbation of intercellular lipids. The results indicated that, from pure drug solution (5 mg/mL) about 88.63% cumulative percentage of drug permeated across porcine buccal mucosa with flux of 0.0235 mg.h-1 cm-2. However, the optimized formulation with sodium taurocholate increased flux (0.0523 mg.h-1 cm-2) and cumulative amount of drug permeated (65.44%) in comparison to formulation without permeation enhancer (38.45%, 0.0186 mg.h-1 cm-2) with enhancement ratio of 2.81.

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Histological and bioadhesion studies on buccal bioadhesive tablets containing a penetration enhancer sodium glycodeoxycholate

Cited by 26 publications

References 15 publications

Chemical Methods for Enhancing Oral Mucosal Delivery

Chemical Methods for Enhancing Oral Mucosal Delivery

In Vitro Evaluation of Various Buccal Permeation Enhancing Systems for PACAP (Pituitary Adenylate Cyclase-Activating Polypeptide)

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