Cordyceps cicadae (C. cicadae) is one of the most valued traditional Chinese medicines (TCM) and have been used for about 1,600 years in China. Both TCM works and modern pharmacological studies indicate that C. cicadae exhibits a variety of biological functions, including vision improvement and protection of renal function. There are at least five active ingredients in C. cicadae, suggesting that further exploration on bioactive metabolites of C. cicadae is expected to expand for its application scope and better exert its healthcare efficacy. Because of the shortage of wild C. cicadae, artificially cultivated is an ideal substitute. The methods we developed include fruiting body production based on wild culture matrix, cultivation based on infected nymphs, liquid fermentation of mycelium. Safety evaluation of the artificially cultivated C. cicadae is important in development of C. cicadae-related product. No toxic effect was observed in the acute toxicity test (piglet), 3 different test systems of genotoxicity test, a 90day oral toxicity test (rats), as well as teratogenicity test of C. cicadae mycelium. C. cicadae possesses multiple pharmacological activities that offers several featured advantages such as low toxicity, low price and easy availability of raw materials from artificial cultivation, paving a broad way for functional products and supplements incorporating healthcare foods, cosmetics, biological agriculture, and pharmaceuticals.
Cataracts, a prevalent age-related eye condition, pose a significant global health concern, with rising rates due to an aging population and increased digital device usage. In Taiwan, cataract prevalence is particularly high, reaching up to 90% among individuals aged 70 and above. The lens of the eye absorbs short-wave light, which can lead to oxidative stress in lens epithelial cells and contribute to cataract formation. Exposure to ultraviolet (UV) light further exacerbates the risk of cataracts by generating reactive oxygen species. Heat-shock proteins (HSPs), involved in protein maintenance and repair, have been linked to cataract development. Cordyceps cicadae (C. cicadae), a traditional Chinese medicine, has a long history of use and is known for its pharmacological effects. N6-(2-hydroxyethyl) adenosine (HEA), a bioactive compound found in C. cicadae, exhibits anti-inflammatory, immunomodulatory, and neuroprotective properties. Previous studies have shown that C. cicadae mycelial extracts improve dry eye disease and reduce intraocular pressure in animal models. Additionally, C. cicadae possesses antioxidant properties, which are beneficial for combating cataract formation. In this study, we aim to evaluate the preventive efficacy of C. cicadae mycelial extracts in UV-induced cataract development. By investigating the ameliorative effects of C. cicadae on eye diseases and its potential role in ocular health improvement, we hope to uncover new options for cataract prevention and provide insights into the mechanisms of action. The findings of this research could provide a novel approach for nutritional supplements targeting cataract prevention, offering potential benefits in the field of ocular health.
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