Neuroprotective Effects of Cordyceps cicadae (Ascomycetes) Mycelium Extract in the Rat Model of Optic Nerve Crush

Wen, Yao‐Tseng; Jhou, Bo-Yi; Hsu, Jui-Hsia; Fu, Hsin-I; Chen, Yen‐Lien; Shih, Yang-Chia; Chen, Chin‐Chu; Tsai, Rong‐Kung

doi:10.1615/intjmedmushrooms.2021041522

Cited by 5 publications

(3 citation statements)

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“…The positive effects observed in the current study can be attributed to a specific bioactive compound found in C. cicadae mycelium called HEA. Previous reports have highlighted the anti-inflammatory, immunomodulatory, and neuroprotective properties of HEA [ 23 , 24 , 25 , 26 ]. In our research, we observed that the water extract of C. cicadae exhibits a superior preventive effect compared to the ethanol extract.…”

Section: Discussionmentioning

confidence: 99%

“…According to the present study, the positive effects observed with C. cicadae mycelium may be attributed to a specific bioactive component called N6-(2-hydroxyethyl) adenosine (HEA) [ 21 , 22 ]. HEA has been previously reported to possess several beneficial properties, including antioxidant, anti-inflammatory, immunomodulatory, and neuroprotective effects [ 23 , 24 , 25 , 26 , 27 ]. By exerting these effects, HEA may help mitigate the defective conditions associated with eye disease and contribute to an overall improvement in ocular health.…”

Section: Introductionmentioning

confidence: 99%

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Preventative Effects of Cordyceps cicadae Mycelial Extracts on the Early-Stage Development of Cataracts in UVB-Induced Mice Cataract Model

Chang

Jhou

et al. 2023

Nutrients

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Cataracts, a prevalent age-related eye condition, pose a significant global health concern, with rising rates due to an aging population and increased digital device usage. In Taiwan, cataract prevalence is particularly high, reaching up to 90% among individuals aged 70 and above. The lens of the eye absorbs short-wave light, which can lead to oxidative stress in lens epithelial cells and contribute to cataract formation. Exposure to ultraviolet (UV) light further exacerbates the risk of cataracts by generating reactive oxygen species. Heat-shock proteins (HSPs), involved in protein maintenance and repair, have been linked to cataract development. Cordyceps cicadae (C. cicadae), a traditional Chinese medicine, has a long history of use and is known for its pharmacological effects. N6-(2-hydroxyethyl) adenosine (HEA), a bioactive compound found in C. cicadae, exhibits anti-inflammatory, immunomodulatory, and neuroprotective properties. Previous studies have shown that C. cicadae mycelial extracts improve dry eye disease and reduce intraocular pressure in animal models. Additionally, C. cicadae possesses antioxidant properties, which are beneficial for combating cataract formation. In this study, we aim to evaluate the preventive efficacy of C. cicadae mycelial extracts in UV-induced cataract development. By investigating the ameliorative effects of C. cicadae on eye diseases and its potential role in ocular health improvement, we hope to uncover new options for cataract prevention and provide insights into the mechanisms of action. The findings of this research could provide a novel approach for nutritional supplements targeting cataract prevention, offering potential benefits in the field of ocular health.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preventative Effects of Cordyceps cicadae Mycelial Extracts on the Early-Stage Development of Cataracts in UVB-Induced Mice Cataract Model

Chang

Jhou

et al. 2023

Nutrients

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“…To understand the associated mechanisms, the rodent optic nerve crush (ONC) model can be used and later extrapolated to NDs [ 130 ]. C. cicadae mycelium extract provided neuroprotection in the ONC rat model through anti-apoptotic and anti-inflammatory effects by improving retinal ganglion cell (RGC) density and P1-N2 amplitude [ 131 ], which intensified with visual–spatial attention in the visual cortex. The butanol fraction protected rat adrenal pheochromocytoma (PC12) cells against glutamate-induced oxidative damage.…”

Section: Neuroprotective Potential Of Cordyceps Ex...mentioning

confidence: 99%

Unique Bioactives from Zombie Fungus (Cordyceps) as Promising Multitargeted Neuroprotective Agents

Sharma,

2023

Nutrients

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Cordyceps, also known as “zombie fungus”, is a non-poisonous mushroom that parasitizes insects for growth and development by manipulating the host system in a way that makes the victim behave like a “zombie”. These species produce promising bioactive metabolites, like adenosine, β-glucans, cordycepin, and ergosterol. Cordyceps has been used in traditional medicine due to its immense health benefits, as it boosts stamina, appetite, immunity, longevity, libido, memory, and sleep. Neuronal loss is the typical feature of neurodegenerative diseases (NDs) (Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS)) and neurotrauma. Both these conditions share common pathophysiological features, like oxidative stress, neuroinflammation, and glutamatergic excitotoxicity. Cordyceps bioactives (adenosine, N6-(2-hydroxyethyl)-adenosine, ergosta-7, 9 (11), 22-trien-3β-ol, active peptides, and polysaccharides) exert potential antioxidant, anti-inflammatory, and anti-apoptotic activities and display beneficial effects in the management and/or treatment of neurodegenerative disorders in vitro and in vivo. Although a considerable list of compounds is available from Cordyceps, only a few have been evaluated for their neuroprotective potential and still lack information for clinical trials. In this review, the neuroprotective mechanisms and safety profile of Cordyceps extracts/bioactives have been discussed, which might be helpful in the identification of novel potential therapeutic entities in the future.

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Clinical evaluation of the short-term effects of Cordyceps cicadae mycelium in lowering intraocular pressure

Hsu

Chang

et al. 2022

Journal of Functional Foods

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Neuroprotective Effects of Cordyceps cicadae (Ascomycetes) Mycelium Extract in the Rat Model of Optic Nerve Crush

Cited by 5 publications

References 0 publications

Preventative Effects of Cordyceps cicadae Mycelial Extracts on the Early-Stage Development of Cataracts in UVB-Induced Mice Cataract Model

Preventative Effects of Cordyceps cicadae Mycelial Extracts on the Early-Stage Development of Cataracts in UVB-Induced Mice Cataract Model

Unique Bioactives from Zombie Fungus (Cordyceps) as Promising Multitargeted Neuroprotective Agents

Clinical evaluation of the short-term effects of Cordyceps cicadae mycelium in lowering intraocular pressure

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