Cerebral palsy (CP) is the main cause of physical disability in childhood and is an important health issue that has a strong socioeconomic impact. There is no effective treatment for CP and therapeutic approaches report only partial benefits for affected people. In this study we assessed the effects of growth hormone (GH) treatment combined with psychomotor and cognitive stimulation in the neurodevelopment of children with CP and GH deficiency (GHD). The study was carried out in 11 patients (7 boys and 4 girls; 4.12 ± 1.31 years) with GHD and CP who were treated with recombinant GH (rGH) and psychomotor and cognitive stimulation during 2 months. Battelle Developmental Inventory Screening Test (BDIST) was performed 2 months before commencing GH treatment, just before commencing GH administration, and after 2 months of combined treatment involving GH and cognitive stimulation. Psychomotor and cognitive status did not change during the period in which only cognitive stimulation was performed; however, significant improvements in personal and social skills, adaptive behavior, gross motor skills and total psychomotor abilities, receptive and total communication, cognitive skills and in the total score of the test (P < 0.01), and in fine motor skills and expressive communication (P < 0.02) were observed after the combined treatment period. Therefore, GH replacement together with psychomotor and cognitive stimulation seem to be useful for the appropriate neurodevelopment of children with GHD and CP.
Estado de revisión: Este documento fue publicado en su primera versión en Documentos de la revista Química Clínica 1996; 15(6): 445-449. La presente versión revisa dicha información, introduce aspectos nutricionales no tratados anteriormente e incorpora un análisis DAFO de la situación actual respecto a la evaluación del estatus de vitamina E.
Up to 150 species of leguminous are used in human and animal feeding, being the most relevant to human consumption beans, lentils, peas, chickpeas, broad beans and cowpeas. Pulses are rich in proteins, slow assimilation carbohydrate, minerals (calcium, iron, zinc), soluble fibre and contain minor amounts some bioactive components. In
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