Two-component mixtures of cephapirin Na and cefuroxime Na were assayed by first-and second-derivative spectrophotometric methods using a "zeFo-crossing" technique of measurement. The relative ease offered by this technique for the quantification of these drugs with closely overlapping spectral bands was clearly demonstrated. Beer's law holds up to 40 pg ml-1 for both cephalosporins. The detection limits of cephapirin Na and cefuroxime Na, at a 0.05 level of significance, were calculated to be 0.34 and 0.85 pg ml-1, respectively, in the first-derivative mode and 0.37 and 0.64 pg ml-1 in the second-derivative mode. The results of the determination of these antibiotics in mixtures of injectable dosage forms are also presented.
Sensitive methods for the determination of iron(II1) alone and of iron(II1) and copper( 11) in mixtures, using 4,6-dihydroxy-2-mercaptopyrimidine (Bthiobarbituric acid), by normal and derivative spectrophotometry have been studied and compared experimentally. Fundamental conditions for the determination and the composition of the iron( 111) -2-thiobarbituric acid complex are discussed. A statistical analysis of the results is reported.
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