Spectrophotometric assay for chloramphenicol and some derivatives in the pure form and in formulations

Morelli, Basilio

doi:10.1016/0731-7085(87)80068-7

Cited by 24 publications

(10 citation statements)

References 14 publications

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“…The least square treatment of calibration data yielded the regression equation A = 0.0019 + 1.3979C with a correlation coefficient of 0.9999, indicating the excellent linearity of the calibration curve. The 95% confidence limits 21 for slopes and intercepts of the regression lines pointed towards a high reproducibility of the proposed method. In order to verify that the developed method is free from procedural errors, the experimental intercept, a, of the regression line was tested for significance of the deviation from the expected value zero.…”

Section: Development and Validation Of Analytical Methods Calibration mentioning

confidence: 94%

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Khan¹,

Chaudhary²,

Patro³

et al. 2009

ScienceAsia

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A simple, sensitive spectrophotometric method was developed for the determination of rabeprazole sodium (RA) in pure form and for pharmaceutical formulations. The charge transfer interaction between RA and 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) as an acceptor was investigated spectrophotometrically. Variables affecting the reaction were studied and optimized. The proposed method was applied successfully to the determination of RA in its pure form and pharmaceutical dosage forms with good accuracy and precision. The formation of charge transfer complex and the site of interaction was confirmed by using UV-Visible spectrophotometry, FT-IR spectrometry, and 1 H NMR techniques. Based on Job's method of continuous variation plots, the obtained results indicate the formation of 1:1 charge transfer complex with a general formula [(RA) (DDQ)]. Statistical comparison of the results with the reference method shows excellent agreement and indicates no significant differences in accuracy or precision.

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Section: Development and Validation Of Analytical Methods Calibration mentioning

confidence: 94%

Untitled

Khan¹,

Chaudhary²,

Patro³

et al. 2009

ScienceAsia

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“…Data processing was performed by Excalibur 1.4 software. Samples for HPLC-MS/MS were prepared and analyzed by using the procedure described for the quantitative determination [2][3][4][5].…”

Section: Methodsmentioning

confidence: 99%

“…Their wide pharmaceutical application causes an ever-growing interest for fast, simple and reliable analytical methods for analytical determinations in binary mixtures. Cephalosporins liquid binary mixtures have already been studied by Morelly [2][3][4][5] by using first-and second-derivative spectrophotometry. Binary mixtures of cephalothin and clavulanic acid were analyzed by means of first derivative spectrophotometry [6].…”

Section: Introductionmentioning

confidence: 99%

Determination of cephalosporins in solid binary mixtures by polarized IR- and Raman spectroscopy

Koleva

Kolev

Spiteller

2008

Journal of Pharmaceutical and Biomedical Analysis

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“…Regression analysis of the calibration data also make it possible to evaluate the error, S c , in the determination of a given concentration of verapamil hydrochloride [39]. Figure 6 shows the graph of S c against the concentration of verapamil hydrochloride.…”

Section: Analytical Datamentioning

confidence: 99%

Spectrophotometric determination of verapamil hydrochloride in drug formulations with chloramine-T as oxidant.

Rahman

Hoda

2002

Analytical and Bioanalytical Chemistry

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A new spectrophotometric method is described for the determination of verapamil hydrochloride, based on its oxidation with chloramine-T in hydrochloric acid medium. It produces a yellow colored compound with maximum absorbance at 425 nm. Beer's law was obeyed in the concentration range 0-340 micro g mL(-1) with molar absorptivity 2 x 10(3) L mol(-1) cm(-1) and RSD 0.3-0.82%. All variables were studied to optimize the reaction conditions. No interferences were observed from the common excipients present in the formulations. The method has been applied successfully to the determination of the drug in pharmaceutical preparations. Statistical comparison of the results with those from the reference method reveals excellent agreement and confirms that accuracy and precision are not significantly different.

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Spectrophotometric assay for chloramphenicol and some derivatives in the pure form and in formulations

Cited by 24 publications

References 14 publications

Untitled

Untitled

Determination of cephalosporins in solid binary mixtures by polarized IR- and Raman spectroscopy

Spectrophotometric determination of verapamil hydrochloride in drug formulations with chloramine-T as oxidant.

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