Spectrophotometric determination of verapamil hydrochloride in drug formulations with chloramine-T as oxidant.

Rahman, Nafisur; Hoda, Nasrul

doi:10.1007/s00216-002-1521-6

Cited by 19 publications

(5 citation statements)

References 25 publications

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“…The solutions of the complex are yellow in color and have absorption maxima at 425 nm and are subject to the Bouguer-Lambert-Beer's law in the range of concentrations of 0-340 μg/ml. The proposed method was successfully applied to determine verapamil hydrochloride in medical form [123].…”

Section: Methods Of Analysis Of Verapamilmentioning

confidence: 99%

Analysis of Approaches to the Development and Validation of the Methods of Analysis of Some Active Pharmaceutical Ingredients From the Group of Calcium Channel Blockers in Drugs and Biological Liquids

Logoyda

2019

Int J App Pharm

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Calcium channel blockers prevent calcium from entering cells of the heart and blood vessel walls, resulting in lower blood pressure. Calcium channel blockers, also called calcium antagonists, relax and widen blood vessels by affecting the muscle cells in the arterial walls. Physico-chemical analysis methods are increasingly being introduced into fundamental pharmaceutical research and pharmaceutical analysis practice, taking into account their high sensitivity, accuracy, specificity and expressiveness. Analytical method development is increasingly being introduced into fundamental pharmaceutical research and pharmaceutical analysis practice, taking into account their high sensitivity, accuracy, specificity and expressiveness. Search criteria was analytical method development for medicines from group of calcium channel blockers. Literature survey has been done in range of years 1990-2018 to make the review updated and comprehensive and to show the new approacheches to the development of the methods of analysis of calcium channel blockers. The sources were world recognized journals and key words used as filter were calcium channel blockers, amlodipine, nifedipine, verapamil, validation, method development, spectrophotometry, HPLC, UHPLC. Chromatographic methods of analysis amongst others have the greatest specificity and objectivity and allow for qualitative and quantitative determination of API in combinated dosage forms and biological fluids without prior separation of the components. We can conclude that analysts are constantly working on developing new methods of analysis and their optimization in order to save time and consumables, which also ensures the efficiency of the developed method. The main disadvantage of the described methods of API analysis can be considered long term from the beginning of chromatography to API release and specific solvents used as the mobile phase in HPLC. It is necessary to develop methods and to select such chromatographic conditions that will provide high speed and high efficiency at lower pressure of the system. This reduces the amount of used mobile phase, which reduces cost analysis accordingly, while at the same time providing the necessary specificity, accuracy and reproducibility of the results of the analysis during quality control. Also, the reduction of analysis time is achieved by simplifying the conditions for sample preparation.

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Section: Methods Of Analysis Of Verapamilmentioning

confidence: 99%

Analysis of Approaches to the Development and Validation of the Methods of Analysis of Some Active Pharmaceutical Ingredients From the Group of Calcium Channel Blockers in Drugs and Biological Liquids

Logoyda

2019

Int J App Pharm

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“…Several analytical methods are reported in the literature for quantification of verapamil in plasma, urine, drugs and some other clinical samples. Some of these reports including fluorimetery, 6 spectrophotometry, 7,8 gas chromatography, [9][10][11][12] ion-chromatography, 13 HPLC, [14][15][16][17][18] HPLC/MS-MS, 19,20 LC-ESI-MS, 21 SPME-LC-ESI-MS, 22 MIP-LC-MS, 23 and electrochemical methods. 24 In spite of higher selectivity presented by above mentioned methods, most of them require sophisticated equipment and are costly, time consuming and also suffer from some disadvantages such as intricate and tedious operational procedure, and high material consumption which is quite inconvenient for for routine clinical applications.…”

Section: Introductionmentioning

confidence: 99%

Direct Monitoring of Verapamil Level in Exhaled Breath Condensate Samples

et al. 2019

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Background: In this research, an enhanced fluorimetric assay was developed for the direct monitoring of verapamil in exhaled breath condensate (EBC). The method is based on a binding–induced rigidity inside the sodium dodecyl sulfate (SDS) micelle which eliminate collisional quenching and vibrational modes responsible for non-radiative decay. This process produces an enhancement in the emission intensity of verapamil. Methods: Fluorescence intensity measurements were made at 15 ˚C on a FP-750 spectroﬂuorometer with maximum excitation and emission wavelengths of 280 nm and 310 nm, respectively. The important parameters influencing the analytical signal in experimental steps were investigated and optimized. The method was validated with considering of the linearity, recovery and limit of detection. Results: Under the optimized experimental conditions, the calibration graph was linear in the range of 0.02 − 12.0 µg.mL−1 of verapamil with a detection limit of 0.008 µg.mL–1. Conclusion: The proposed method was found to be suitable and accurate for the determination of verapamil and the validated method was successfully used for analysis of verapamil in EBC of patients receiving verapamil with the satisfactory results.

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“…In the literature are also found several methods for determination of VP in formulations and in biological fluids such as high performance liquid chromatography . Besides, there are methods for VP analysis based on UV‐Visible absorption spectroscopy , potentiometry , capillary electrophoresis and electroanalytical methods .…”

Section: Introductionmentioning

confidence: 99%

Selective Determination of Verapamil in Pharmaceutics and Urine Using a Boron‐doped Diamond Electrode Coupled to Flow Injection Analysis with Multiple‐pulse Amperometric Detection

et al. 2018

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This work presents a simple and low‐cost method for fast and selective determination of Verapamil (VP) in tablets and human urine samples using a boron‐doped diamond working electrode (BDD) coupled to a flow injection analysis system with multiple pulse amperometric detection (FIA‐MPA). The electrochemical behaviour of VP in 0.1 mol L−1 sulfuric acid showed three merged oxidation peaks at around +1.4 V and upon reverse scan, one reduction peak at 0.0 V (vs. Ag/AgCl). The MPA detection was performed applying a sequence of three potential pulses on BDD electrode: (1) at +1.6 V for VP oxidation, (2) at +0.2 V for reduction of the oxidized product and (3) at +0.1 V for cleaning of the working electrode surface. The FIA system was optimized with injection volume of 150 μL and flow rate of 3.5 mL min−1. The method showed a linear range from 0.8 to 40.0 μmol L−1 (R>0.99) with a low limit of detection of 0.16 μmol L−1, good repeatability (RSD<2.2 %; n=10) and sample throughput (45 h−1). Selective determination of VP in urine was performed at+0.2 V due to absence of interference from ascorbic and uric acids in this potential. The addition‐recovery tests in both samples were close to 100 % and the results were similar to an official method.

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Spectrophotometric determination of verapamil hydrochloride in drug formulations with chloramine-T as oxidant.

Cited by 19 publications

References 25 publications

Analysis of Approaches to the Development and Validation of the Methods of Analysis of Some Active Pharmaceutical Ingredients From the Group of Calcium Channel Blockers in Drugs and Biological Liquids

Analysis of Approaches to the Development and Validation of the Methods of Analysis of Some Active Pharmaceutical Ingredients From the Group of Calcium Channel Blockers in Drugs and Biological Liquids

Direct Monitoring of Verapamil Level in Exhaled Breath Condensate Samples

Selective Determination of Verapamil in Pharmaceutics and Urine Using a Boron‐doped Diamond Electrode Coupled to Flow Injection Analysis with Multiple‐pulse Amperometric Detection

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