The Brain-Derived Neurotrofic Factor (BDNF) is one of the most important neurotrophins in the brain and it is suggested influences the activity of the serotonergic, noradrenergic and dopaminergic pathways. In the last few years, it has been hypothesized that BDNF level is related with depression and sleep. Several studies show that depressive subjects present low levels of BDNF in the brain. Poor sleep quality is also related with alterations in the BDNF concentration. Some authors argue that most of the cases show that impaired sleep quality increases the stress and, consequently, the vulnerability to depressive disorders, suggesting that there is a relationship between sleep, depression and BDNF levels.
OBJECTIVE: Late-life depression is an under-diagnosed and under-treated disease that reduces the well-being of older adults. Executive dysfunction is another critical impairment in elderly depressed individuals which further disrupts their everyday functioning. This systematic review aims to analyze the association between executive function and depression severity in elderly individuals diagnosed with major depressive disorder.
METHOD:The studies were retrieved from MEDLINE/PubMed, ISI Web of Knowledge and PsychInfo, after a search strategy combining the terms "depression", "executive function", "neuropsychological assessment", "elderly" and "late life". Study selection, data collection and quality ratings was performed by two independent raters. RESULTS: A total of 1,130 articles were found but only 8 studies met the defined eligibility criteria and evaluated the association between depression severity and executive functioning. Six out of 8 studies found an association between depression severity and executive function, with correlations ranging from small to large (r= -0.15 to -0.53). The included reports had several methodological limitations such as selective data reporting, non-comprehensive executive function assessment and not controlling potential biases. CONCLUSION: Depression severity may be more strongly correlated with a specific set of executive abilities although it also seems to be a broad-based association with executive functioning as a whole. Future high-quality prospective studies are recommended in order to understand the causal relationship between depression severity and executive functioning taking into account possible mediators such as age-related or neurodegenerative cognitive impairment, educational level and other clinic characteristics (e.g. age of onset, medication).
Objetivos: A presente investigação teve como principais objetivos descrever a qualidade subjetiva do sono e as perturbações do sono e analisar a intensidade dos sintomas depressivos e dos sentimentos de solidão em idosos institucionalizados; comparar estes dados com um grupo de idosos não institucionalizados e analisar a relação entre estas variáveis nos dois grupos.Métodos: Este estudo insere-se no Projeto Trajetórias do Envelhecimento de Idosos em Resposta Social de onde foi retirada uma amostra de cento e quarenta idosos sem défice cognitivo, com 70 institucionalizados e 70 não institucionalizados emparelhados por idade, sexo, escolaridade e estado civil. A média de idades foi de 76,58 (DP = 6,10), incluindo 104 mulheres e 36 homens. Como instrumentos foram utilizados um Questionário Sociodemográfico, o Questionário sobre o Sono na Terceira Idade, a Escala Geriátrica de depressão e a Escala de Solidão da Universidade da Califórnia, Los Angeles.Resultados: Verificou-se que os idosos institucionalizados apresentavam mais sentimentos de solidão do que os não institucionalizados. Contudo, não se verificaram diferenças entre os dois grupos em relação aos sintomas depressivos, qualidade subjetiva do sono ou perturbações do sono, com algumas exceções: os idosos residentes na comunidade mostraram ter a perceção de demorar mais tempo a adormecer, de acordar mais cedo e de ter mais pesadelos. Através de uma análise correlacional verificou-se, na amostra global, que quanto pior a qualidade subjetiva do sono mais sintomas depressivos se observavam e quanto mais sintomas depressivos, mais sentimentos de solidão, não havendo, contudo, relação entre o sono e a solidão.Conclusões: Concluímos que a situação de institucionalização se acompanha de mais sentimentos de solidão, mas não de sintomas depressivos ou de pior qualidade de sono. Por esse motivo, sugere-se que se desenvolvam programas de intervenção dirigidos à solidão em idosos institucionalizados.
Psychological inflexibility is defined as a transdiagnostic mechanism characterized by rigid efforts to control psychological reactions to painful, undesirable, unpleasant internal experiences. The Acceptance and Action Questionnaire-University Students (AAQ-US) was designed to assess students’ academic context-related psychological inflexibility. This study adapted the AAQ-US to Portuguese and examined its factor structure, validity, and reliability in a college student sample (sample 1:
N
= 262). Exploratory factor analysis and parallel analysis suggested a two-factor structure. A confirmatory factor analysis was conducted in a second sample to cross-validate the AAQ-US factor structure (sample 2:
N
= 260). One higher-order factor (psychological inflexibility) with two lower-order factors (cognitive fusion and experiential avoidance) revealed a very good fit to the data. The AAQ-US total and dimensions showed good reliability, convergent and incremental validity. Overall, the Portuguese version of the AAQ-US is a reliable and valid instrument for assessing context-specific psychological inflexibility in university students.
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