Increased FNDC5 expression in white and brown adipose tissues may have a cachectic effect in mice with induced cancer. However, it is not possible to explain the mechanism of the relationship between irisin and gastric cancer development on the basis of the results of this study.

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ÖZAlveolar Soft Part Sarkoma, karakteristik histolojik özellikleri olan, tipik olarak çocuk ve adölesanlarda izlenen, kötü prognozlu, nadir görülen bir yumuşak doku tümörüdür. Bu tümörler sıklıkla alt ekstremite ve gövdenin derin yumuşak dokularında gelişim gösterirler. Her ne kadar yavaş bir klinik seyir izlense de geç metastazları ile kötü bir prognoza sahiptirler. On altı yaşında kız çocuğu sol kolunda şişlik ve ağrı yakınması ile başvurdu. Deltoid ve biseps braki lateralis kasları arasında gelişmiş tümöral gelişime cerrahi rezeksiyon uygulandı. Histopatolojik olarak, vaskulerize fibröz septalar ile ayrılmış, geniş eozinofilik/berrak sitoplazmalı poligonal biçimli hücrelerin kümelenmeler ve alveol benzeri yapılar oluşturduğu neoplastik gelişim izlendi. Tümöral hücrelerde MyoD1 ve CD10 immünohistokimyasal boyamaları pozitifti ve diyastaz rezistan PAS pozitif sitoplazmik cisimcikler görüldü. Olgumuz seyrek görülmesi ve beklenmeyen lokalizasyonu nedeni ile histopatolojik ve immünohisto-kimyasal özellikleri ile sunulmuş ve literatür gözden geçirilmiştir. ASPS tanısı; klinik, morfolojik, arşitektürel bulguların yanı sıra immünohistokimyasal bulguların birlikte yorumlanması ile olasıdır.Anahtar kelimeler: Alveolar soft part sarkom, immünohistokimya, ayırıcı tanı ABSTRACT Alveolar Soft Part Sarcoma is a rare soft tissue tumor with characteristic histological features, typically seen in children and adolescents, with bad prognosis. These tumors often develop in the deep soft tissues of the lower extremities and body. Although they have a slow clinical course, they have a bad prognosis with late metastases. A 16-yearold girl applied with a complaint of swelling and pain in her left arm. Surgical resection was performed on advanced tumor growth between deltoid and biceps brachiolateralis muscles. Neoplastic development which polygonal cells with wide eosinophilic / clear cytoplasm were separated histopathologically by vascularized fibrous septa in clusters and alveolar like structures, is observed. MyoD1 and CD10 immunohistochemical stains were positive for tumor cells and diastase resident PAS-positive cytoplasmic substances were observed in tumor cells. Our case was presented due to rare occurrence and unexpected localization with its histopathological and immunohistochemical characteristics and literature review conducted on this subject. Establishment of diagnosis of ASPS is possible by interpretation of immunohistochemical findings together with clinical, morphological and architectural findings.

Tel: 0 222 237 48 00 (J Curr Pathol 2017, 2:32-34) ÖZET amaç: seroid granülomu, biyolojik antioksidanların kısmi yoksunluğunda, makrofajlar içerisinde biriken substratların oto-oksidasyonu ile seroide dönüşümü sonucu gelişen olağan dışı ve ilginç lezyonlardır. Burada, 39 yaşında kadın olguda saptanan seroid granülomunun tanısal özellikleri sunulmaktadır.olgu: Fibrokistik hastalık nedeniyle cerrahi müdahale geçirmiş hastada, postoperatif ikinci yılda saptanan, ultrasonografik olarak BI-rADs kategori 5 olarak değerlendirilen kitleden alınan tru-cut biyopside, histomorfolojik ve histokimyasal özellikleri ile seroid granülomu tanısına ulaşılmıştır. Tıbbi literatürde; endometrium, endometriotik kist duvarı, over, serviks, plasenta, safra kesesi ve meme lokalizasyonunda tanımlanmış az sayıda olgu vardır. Bu lezyonların hemoraji ve nekroz ortamında gelişebileceği gibi, tümör nekrozu ya da endometriyoz ile de ilişkili olabileceği de belirtilmektedir.Sonuç: seroid granülomu, rastlantısal saptanan benign lezyonlar olmakla birlikte klinik ve radyolojik olarak maligniteyi taklit etmeleri nedeniyle ayırıcı tanıda anımsanması gerekmektedir.Anahtar Sözcükler: seroid, Granülomatöz mastit aBSTraCT aim: Ceroid granulomas are unusual and interesting lesions that are formed from auto-oxidation and ceroid transformation of substrates accumulating in macrophages, in case of relative lack of biological antioxidants. Diagnostic features of ceroid granulomas diagnosed in a 39-years-old woman are represented Case: Ceroid granuloma was diagnosed at the tru-cut bioposy of a mass ocurring after a surgical operation for fibrocystic changes and evaluated as BI-rADs5, radiologically. There are few cases described in the endometrium, endometriotic cyst wall, ovary, cervix uteri, placenta, bile duct and breast. Conclusion:Although ceroid granulomas are benign lesions, they can mimic malignancy clinically and/or radiologically.

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Background: To analyze retrospectively the results of HPV DNA, immunocytochemical HPV antibody staining of gynecologic smear samples evaluated in a public hospital and to observe their compatibility with histologic diagnosis. At the same time, the contribution of ICC HPV Ab staining experience results to the morphological evaluation is discussed in this paper.Methods: In this study, liquid-based cytology test results of patients who applied to the gynecology between 2014 and 2017 were analyzed. The Ultravision Quanto Detection System was modified for immunocytochemical staining. HPV DNA tests were performed with the Qiagen Hybrid Capture test.Results: The 18404 test result was included in the research. The percentage of smear that epithelial cell atypia is seen was 3.4%, the rate of ASC/SIL was 1.89%. Compared to the first 3 years of the study, the increase in the rate of LSIL is seen with a partial decrease in ASCUS rate in year 2017 (p<0.05). The atypical positive test rate with histologic confirmation was 73.61%. Among 138 HPV Ab results, 58.7% of them were negative and 41.3% of them were positive. Sensitivity and specificity rates were determined 76.19% and 52.17% for SIL. Among 53 HPV DNA results (53% negative and 46.3% positive); sensitivity and specificity rates were determined 92.86% and 50% for SIL.Conclusions: İmmunocytochemical HPV Ab staining provided statistically significant contribution to LSIL (p<0.05).  It is thought that it also will provide additional evidence for morphological findings while cytological evaluation and may help the clinician in managing the conditions for disease.

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