Vitamin D deficiency negatively affects both the intestinal epithelial integrity and bone metabolism in children with Celiac disease

Aydemir, Yusuf; Erdoğan, Bahattin; Türkeli, Ahmet

doi:10.1016/j.clinre.2020.08.002

Cited by 12 publications

(4 citation statements)

References 22 publications

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“…The link between CD and HypoD is not entirely clear: since vitamin D has an immunomodulatory and controlling action on intestinal permeability, it has been hypothesized that low levels of this hormone may play a role in the pathogenesis and development of CD by counteracting the mechanisms leading to the onset of intestinal autoimmunity [ 76 ]. The prevalence of HypoD in patients with CD varies among studies: low levels appear to be significantly related to CD in pediatric populations [ 77 , 78 ], while differences are smaller as compared to healthy controls when considering adult patients [ 73 ]. However, CD, as other inflammatory bowel diseases, is also linked to alterations in bone metabolism, so celiac subjects have lower BMD values than non-celiac subjects (up to 70% of cases in some studies) [ 79 ].…”

Section: The Role Of Vitamin D In Metabolic Syndrome Celiac Disease A...mentioning

confidence: 99%

Gluten-Free Diet and Metabolic Syndrome: Could Be a Not Benevolent Encounter?

et al. 2023

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Celiac disease is a rising disorder and is becoming frequently diagnosed in recent years. To date, the only available treatment is the gluten-free diet (GFD). The role of gluten on components of metabolic syndrome and on related inflammatory response is still unclear due to controversial results. In recent years, scientific focus on this topic has been growing up, in particular regarding the role of the GFD on glycometabolic parameters and diabetes. In addition, studies on the remaining components showed discordant results, which was likely due to heterogeneous and large celiac disease populations and to the lack of prospective studies. Furthermore, knowledge about the role of the GFD on inflammatory cytokines and the relationship among vitamin D and celiac disease, metabolic syndrome (MS) and GFD is needed. In this narrative review, we provided evidence regarding the role of the GFD on glycometabolic parameters, cholesterol, triglycerides, waist circumference, blood pressure and inflammatory cascade, also evaluating the role of vitamin D, trying to summarize whether this nutritional pattern may be a value-added for subjects with dysmetabolic conditions. Finally, due to the limited findings and very low-certainty evidence, predominantly based on observational studies, the real effects of a GFD on different components of MS, however, are unclear; nevertheless, an improvement in HDL levels has been reported, although data on glycemic levels are discordant.

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Section: The Role Of Vitamin D In Metabolic Syndrome Celiac Disease A...mentioning

confidence: 99%

Gluten-Free Diet and Metabolic Syndrome: Could Be a Not Benevolent Encounter?

et al. 2023

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“…In this respect, the neutrophil–to–lymphocyte ratio (NLR), as an inexpensive and widely available marker of inflammation, has been also proposed as a bone loss index in postmenopausal women and as a marker of inflammation in celiac patients [ 72 , 73 ]. Different reports indicate that vitamin D deficiency is common in celiac disease, particularly among children who also showed reduced expression of the vitamin D receptor (VDR) and the two epithelial barrier proteins claudin-2 and E-cadherin, which have important roles in the paracellular pathway and correlate with the histological findings of disease severity [ 74 ]. However, reports about the variation in the serum 25-hydroxy vitamin D levels in celiac disease patients at diagnosis and on a gluten-free diet (GFD) remain conflicting [ 75 ], likely due to heterogeneity among studies and the complexity of vitamin D metabolism.…”

Section: Celiac Diseasementioning

confidence: 99%

Bone Fragility in Gastrointestinal Disorders

Merlotti

Mingiano

Valenti

et al. 2022

IJMS

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Osteoporosis is a common systemic disease of the skeleton, characterized by compromised bone mass and strength, consequently leading to an increased risk of fragility fractures. In women, the disease mainly occurs due to the menopausal fall in estrogen levels, leading to an imbalance between bone resorption and bone formation and, consequently, to bone loss and bone fragility. Moreover, osteoporosis may affect men and may occur as a sequela to different diseases or even to their treatments. Despite their wide prevalence in the general population, the skeletal implications of many gastrointestinal diseases have been poorly investigated and their potential contribution to bone fragility is often underestimated in clinical practice. However, proper functioning of the gastrointestinal system appears essential for the skeleton, allowing correct absorption of calcium, vitamins, or other nutrients relevant to bone, preserving the gastrointestinal barrier function, and maintaining an optimal endocrine-metabolic balance, so that it is very likely that most chronic diseases of the gastrointestinal tract, and even gastrointestinal dysbiosis, may have profound implications for bone health. In this manuscript, we provide an updated and critical revision of the role of major gastrointestinal disorders in the pathogenesis of osteoporosis and fragility fractures.

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“…This phenomenon is most likely a vicious circle in which general trends of hypovitaminosis D during childhood contribute to the onset of CD, and its persistently decreased levels during the clinical course of CD augment disease severity. A recent study indicated that the decreased expression of VDR and epithelial barrier proteins claudin-2 and E-cadherin are positively correlated with histological findings of disease severity [ 69 ]. The authors pointed out that this decreased expression of VDR and epithelial barrier proteins is the result of vitamin D deficiency.…”

Section: Vitamin D and Gastrointestinal Disordersmentioning

confidence: 99%

“…Decreased expression of vitamin D receptor and epithelial barrier proteins claudin-2 and E-cadherin is positively correlated with histological findings of disease severity [ 69 ]…”

Section: Vitamin D and Gastrointestinal Disordersmentioning

confidence: 99%

The Crosstalk between Vitamin D and Pediatric Digestive Disorders

et al. 2022

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Vitamin D is a cyclopentane polyhydrophenanthrene compound involved mainly in bone health and calcium metabolism but also autophagy, modulation of the gut microbiota, cell proliferation, immune functions and intestinal barrier integrity. The sources of vitamin D include sunlight, diet and vitamin D supplements. Vitamin D3, the most effective vitamin D isoform is produced in the human epidermis as a result of sunlight exposure. Vitamin D undergoes two hydroxylation reactions in the liver and kidney to reach its active form, 1,25-dihydroxyvitamin D. Recent studies highlighted a complex spectrum of roles regarding the wellbeing of the gastrointestinal tract. Based on its antimicrobial effect, it was recently indicated that vitamin D supplementation in addition to standard eradication therapy might enhance H. pylori eradication rates. Moreover, it was suggested that low levels of vitamin D might also be involved in the acquisition of H. pylori infection. In terms of celiac disease, the negative effects of vitamin D deficiency might begin even during intrauterine life in the setting of maternal deficiency. Moreover, vitamin D is strongly related to the integrity of the gut barrier, which represents the core of the pathophysiology of celiac disease onset, in addition to being correlated with the histological findings of disease severity. The relationship between vitamin D and cystic fibrosis is supported by the involvement of this micronutrient in preserving lung function by clearing airway inflammation and preventing pathogen airway colonization. Moreover, this micronutrient might exert anticatabolic effects in CF patients. Inflammatory bowel disease patients also experience major benefits if they have a sufficient level of circulating vitamin D, proving its involvement in both induction and remission in these patients. The findings regarding the relationship between vitamin D, food allergies, diarrhea and constipation remain controversial, but vitamin D levels should be monitored in these patients in order to avoid hypo- and hypervitaminosis. Further studies are required to fill the remaining gaps in term of the complex impact of vitamin D on gastrointestinal homeostasis.

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Vitamin D deficiency negatively affects both the intestinal epithelial integrity and bone metabolism in children with Celiac disease

Cited by 12 publications

References 22 publications

Gluten-Free Diet and Metabolic Syndrome: Could Be a Not Benevolent Encounter?

Gluten-Free Diet and Metabolic Syndrome: Could Be a Not Benevolent Encounter?

Bone Fragility in Gastrointestinal Disorders

The Crosstalk between Vitamin D and Pediatric Digestive Disorders

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