The effects of sodium phosphate and polyethylene glycol-electrolyte bowel preparation solutions on 2,4,6-trinitrobenzenesulfonic acid-induced colitis in the rat

Erdoğan, Bahattin; Işıksoy, Serap; Dündar, Emine; Paşaoğlu, Özgül; Bal, Cengiz

doi:10.1078/0940-2993-00318

Cited by 19 publications

(10 citation statements)

References 17 publications

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“…In a study in healthy rats, OSP and PEG caused significantly more colonic mucosal damage compared with a control group and the damage induced by OSP was worse than that caused by PEG [123]. In another study, no significant difference was found either macroscopically or microscopically in terms of the effects of saline, OSP, and PEG solutions in both healthy rats and rats with chemically induced colitis [124].…”

Section: Specific Scenariosmentioning

confidence: 94%

Bowel preparation for colonoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Guideline

et al. 2013

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Background and aim: This Guideline is an official statement of the European Society of Gastrointestinal Endoscopy (ESGE). It addresses the choice amongst regimens available for cleansing the colon in preparation for colonoscopy. Methods: This Guideline is based on a targeted literature search to evaluate the evidence supporting the use of bowel preparation for colonoscopy. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) system was adopted to define the strength of recommendation and the quality of evidence. Results: The main recommendations are as follows. (1) The ESGE recommends a low-fiber diet on the day preceding colonoscopy (weak recommendation, moderate quality evidence). (2) The ESGE recommends a split regimen of 4?L of polyethylene glycol (PEG) solution (or a same-day regimen in the case of afternoon colonoscopy) for routine bowel preparation. A split regimen (or same-day regimen in the case of afternoon colonoscopy) of 2?L PEG plus ascorbate or of sodium picosulphate plus magnesium citrate may be valid alternatives, in particular for elective outpatient colonoscopy (strong recommendation, high quality evidence). In patients with renal failure, PEG is the only recommended bowel preparation. The delay between the last dose of bowel preparation and colonoscopy should be minimized and no longer than 4 hours (strong recommendation, moderate quality evidence). (3) The ESGE advises against the routine use of sodium phosphate for bowel preparation because of safety concerns (strong recommendation, low quality evidence).

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Section: Specific Scenariosmentioning

confidence: 94%

Bowel preparation for colonoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Guideline

et al. 2013

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“…Pockros & Foroozan [8] studied the effect of Golytely lavage on normal colonic mucosal histology and concluded that normal mucosal histology was preserved. Er− dogan et al [9] also reported that administration of sodium phosphate and PEG−ELS did not cause any evident macroscopic or microscopic morphological changes in the rectal mucosa of healthy rats or in the rectal mucosa of rats with colitis. On the other hand, reactive epithelial changes similar to the changes seen in inflammatory bowel disease, such as aphthoid lesions, edema, congestion, and petechiae, have been reported in associa− tion with both sodium phosphate solution and PEG−ELS [11 ± 13].…”

Section: Discussionmentioning

confidence: 97%

Polyethylene Glycol-Electrolyte Lavage Solution Causes Reversible Mucosal Elevation Surrounding a Minute Depressed-Type Rectal Cancer

Yamamoto¹,

Aoyagi²,

Maeda³

et al. 2005

Endoscopy

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A 52−year−old man underwent colonoscopy following prepara− tion with polyethylene glycol−electrolyte lavage solution (PEG− ELS), which revealed a flat elevated lesion with an irregular de− pression in the rectum. Three days after this colonoscopy, flex− ible sigmoidoscopy was performed after preparation with a gly− cerin enema and this examination demonstrated an irregular de− pressed lesion which was not associated with a surrounding elevated lesion. Seven days after the flexible sigmoidoscopy, co− lonoscopy following preparation with PEG−ELS revealed an elevated lesion surrounding the depressed lesion. Fourteen days after this second colonoscopy, flexible sigmoidoscopy following preparation with a glycerin enema showed a depressed lesion and an endoscopic mucosal resection was performed: histologi− cal examination revealed the tumor to be a well−differentiated adenocarcinoma. We report a patient in whom PEG−ELS led to the reversible appearance of an elevated lesion around a minute rectal cancer and believe that this reactive elevated lesion might prove to be a useful clue in the detection of minute rectal can− cers.

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“…9,11 Recently, bowel preparations, enemas, laxatives, and nonsteroidal anti-inflammatory drugs (NSAIDs) have been implicated in the causation of FAC. 8-16 The prevalence and importance of FAC in colonic adenomas was not previously reported. Neutrophilic inflammatory infiltrate of the lamina propria (LP) could be seen in colonic adenomas without accompanying FAC.…”

Section: Introductionmentioning

confidence: 94%

The Prevalence and Importance of Crypt Apoptosis, Focal Active Cryptitis, and Neutrophilic Infiltrate of the Lamina Propria in Colorectal Adenomas

et al. 2013

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Even though apoptotic bodies (ABs) are frequent in colorectal adenomas, their relevance has been covered only in a few studies. Focal active cryptitis (FAC) is a well-known manifestation of several etiologies; however, its prevalence and significance in colonic adenomas were not scrutinized. Likewise, whether the neutrophilic infiltrate of the lamina propria (LP) in colonic adenomas has a clinical or pathologic significance was not previously studied. We attempted to investigate the prevalence and importance of ABs in the cryptal epithelium and of neutrophils in the form of FAC and in the form of LP infiltrates in conventional colorectal adenomas. We conducted a retrospective review study over a 6-year period. We collected 223 conventional adenomas from 156 patients. We studied the interrelationship between these 3 histologic parameters and their potential association with other clinical and pathologic variables. Comparison controls included normal colonic mucosa, hyperplastic polyps, serrated adenomas, and flat adenomas. We found 91 (41%) adenomas to have crypt apoptosis, 40 (18%) to have FAC, and 69 (31%) to have neutrophilic infiltrate of the LP. We found ABs to be more frequent in high-grade adenomas. LP neutrophilic infiltrate was significantly associated with high-grade adenomas and in high-grade adenomas with invasive foci. In contrast, FAC was not associated with high-grade adenomas and was secondary to bowel preparations and drugs. Crypt apoptosis and LP neutrophils might have a potential prognostic value in predicting the biologic behavior of colonic adenomas. FAC in adenomas is a nonspecific finding of no prognostic significance and is related to external stimuli.

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The effects of sodium phosphate and polyethylene glycol-electrolyte bowel preparation solutions on 2,4,6-trinitrobenzenesulfonic acid-induced colitis in the rat

Cited by 19 publications

References 17 publications

Bowel preparation for colonoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Guideline

Bowel preparation for colonoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Guideline

Polyethylene Glycol-Electrolyte Lavage Solution Causes Reversible Mucosal Elevation Surrounding a Minute Depressed-Type Rectal Cancer

The Prevalence and Importance of Crypt Apoptosis, Focal Active Cryptitis, and Neutrophilic Infiltrate of the Lamina Propria in Colorectal Adenomas

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